Published in Angew Chem Int Ed Engl on December 01, 2005
Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker. Nat Nanotechnol (2010) 1.84
A simple DNA gate motif for synthesizing large-scale circuits. J R Soc Interface (2011) 1.68
DNA as a versatile chemical component for catalysis, encoding, and stereocontrol. Angew Chem Int Ed Engl (2010) 1.51
In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors. J Am Chem Soc (2010) 1.06
A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis. J Am Chem Soc (2011) 0.98
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Biomimetic catalysis of intermodular aminoacyl transfer. J Am Chem Soc (2007) 0.78
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Distance dependent interhelical couplings of organic rods incorporated in DNA 4-helix bundles. Bioconjug Chem (2009) 0.77
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol (2013) 8.40
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods (2011) 6.90
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64
A system for the continuous directed evolution of biomolecules. Nature (2011) 2.77
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63
Supercharging proteins can impart unusual resilience. J Am Chem Soc (2007) 2.52
How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol (2006) 2.45
Directed evolution and substrate specificity profile of homing endonuclease I-SceI. J Am Chem Soc (2006) 2.18
Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol (2011) 2.13
DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules. Angew Chem Int Ed Engl (2004) 2.03
Reaction discovery enabled by DNA-templated synthesis and in vitro selection. Nature (2004) 1.99
Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins. Proc Natl Acad Sci U S A (2009) 1.95
DNA-templated organic synthesis and selection of a library of macrocycles. Science (2004) 1.95
Engineering a ligand-dependent RNA transcriptional activator. Chem Biol (2004) 1.94
Photoswitching mechanism of cyanine dyes. J Am Chem Soc (2009) 1.86
A general strategy for the evolution of bond-forming enzymes using yeast display. Proc Natl Acad Sci U S A (2011) 1.85
Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker. Nat Nanotechnol (2010) 1.84
Discovery and biological characterization of geranylated RNA in bacteria. Nat Chem Biol (2012) 1.70
In vivo evolution of an RNA-based transcriptional activator. Chem Biol (2003) 1.69
A de novo protein binding pair by computational design and directed evolution. Mol Cell (2011) 1.65
In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae. Chem Biol (2007) 1.56
Expanding the reaction scope of DNA-templated synthesis. Angew Chem Int Ed Engl (2002) 1.56
A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system. Nat Chem (2011) 1.54
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci U S A (2004) 1.52
Sequence-controlled polymers. Science (2013) 1.50
In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc (2005) 1.47
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Res (2013) 1.46
Directed evolution of ligand dependence: small-molecule-activated protein splicing. Proc Natl Acad Sci U S A (2004) 1.46
Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol (2010) 1.42
Multistep small-molecule synthesis programmed by DNA templates. J Am Chem Soc (2002) 1.42
Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids. Nat Chem (2013) 1.41
Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes. J Am Chem Soc (2003) 1.41
LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nat Chem Biol (2009) 1.29
A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proc Natl Acad Sci U S A (2006) 1.28
Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents. J Am Chem Soc (2007) 1.25
Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection. J Am Chem Soc (2008) 1.23
Nucleic acid evolution and minimization by nonhomologous random recombination. Nat Biotechnol (2002) 1.20
Small-molecule discovery from DNA-encoded chemical libraries. Chem Soc Rev (2011) 1.20
DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes. J Am Chem Soc (2008) 1.18
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol (2011) 1.16
Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity. J Am Chem Soc (2003) 1.15
Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A (2007) 1.15
Creating small-molecule-dependent switches to modulate biological functions. Chem Biol (2005) 1.14
A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA. Proc Natl Acad Sci U S A (2009) 1.12
Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. J Am Chem Soc (2006) 1.10
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc Natl Acad Sci U S A (2013) 1.09
Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol (2006) 1.09
Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. Angew Chem Int Ed Engl (2002) 1.08
Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein. J Am Chem Soc (2006) 1.07
In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors. J Am Chem Soc (2010) 1.06
Two enabling architectures for DNA-templated organic synthesis. Angew Chem Int Ed Engl (2003) 1.06
Directed evolution of protein enzymes using nonhomologous random recombination. Proc Natl Acad Sci U S A (2004) 1.05
Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. Chem Biol (2011) 1.05
Recent advances in the in vitro evolution of nucleic acids. Curr Opin Chem Biol (2002) 1.03
Interaction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment. J Am Chem Soc (2010) 1.03
An in vitro translation, selection and amplification system for peptide nucleic acids. Nat Chem Biol (2009) 1.02
Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. PLoS One (2011) 1.00
A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis. J Am Chem Soc (2011) 0.98
A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry (2013) 0.97
Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells. Methods Enzymol (2012) 0.97
Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers. Chem Biol (2009) 0.96
Cellular uptake mechanisms and endosomal trafficking of supercharged proteins. Chem Biol (2012) 0.95
An in vivo selection system for homing endonuclease activity. Nucleic Acids Res (2002) 0.94
DNA-enabled self-assembly of plasmonic nanoclusters. Nano Lett (2011) 0.92
DNA-templated functional group transformations enable sequence-programmed synthesis using small-molecule reagents. J Am Chem Soc (2005) 0.92
Dissecting protein structure and function using directed evolution. Nat Methods (2007) 0.91
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nat Chem Biol (2012) 0.90
Enhanced functional potential of nucleic acid aptamer libraries patterned to increase secondary structure. J Am Chem Soc (2010) 0.90
Templated synthesis of peptide nucleic acids via sequence-selective base-filling reactions. J Am Chem Soc (2009) 0.90
DNA ligase-mediated translation of DNA into densely functionalized nucleic acid polymers. J Am Chem Soc (2012) 0.89
Effects of template sequence and secondary structure on DNA-templated reactivity. J Am Chem Soc (2008) 0.89
Synthesis of acyclic alpha,beta-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes. J Am Chem Soc (2007) 0.87
Translation of DNA into synthetic N-acyloxazolidines. J Am Chem Soc (2004) 0.86
Solving chemical problems through the application of evolutionary principles. Curr Opin Chem Biol (2007) 0.84
Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis. Angew Chem Int Ed Engl (2005) 0.84
Stereoselectivity in DNA-templated organic synthesis and its origins. J Am Chem Soc (2003) 0.84
Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc (2014) 0.82
Reactivity-dependent PCR: direct, solution-phase in vitro selection for bond formation. J Am Chem Soc (2009) 0.82
Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. J Am Chem Soc (2006) 0.82
DNA-templated synthesis in organic solvents. Chembiochem (2006) 0.82
Discovery of widespread GTP-binding motifs in genomic DNA and RNA. Chem Biol (2013) 0.81
Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection. Chem Biol (2005) 0.80
Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination. Nucleic Acids Res (2007) 0.80
Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces. Adv Healthc Mater (2013) 0.80
Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by nonhomologous random recombination and in vivo selection. Nucleic Acids Res (2007) 0.79
Nucleic-acid-templated synthesis as a model system for ancient translation. Curr Opin Chem Biol (2004) 0.78
Targeted antithrombotic protein micelles. Angew Chem Int Ed Engl (2014) 0.77
Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection. J Am Chem Soc (2006) 0.77
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell (2017) 0.75
Nucleic acids: new life, new materials. Org Biomol Chem (2013) 0.75