Published in Cell Mol Immunol on June 01, 2004
Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int J Biol Sci (2011) 1.70
Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59
Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. PLoS One (2014) 1.57
Inflammation in alcoholic liver disease. Annu Rev Nutr (2012) 1.49
Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease. J Gastroenterol Hepatol (2012) 1.49
Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res (2011) 1.35
Role of cytokines and chemokines in non-alcoholic fatty liver disease. World J Gastroenterol (2012) 1.32
Adipokines in nonalcoholic steatohepatitis: from pathogenesis to implications in diagnosis and therapy. Mediators Inflamm (2009) 1.26
Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health (2010) 1.22
The effect of inflammatory cytokines in alcoholic liver disease. Mediators Inflamm (2013) 1.18
"Second hit" models of alcoholic liver disease. Semin Liver Dis (2009) 1.12
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J Biol Chem (2010) 1.09
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One (2009) 1.01
Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcohol Clin Exp Res (2010) 1.00
Influence of visfatin on histopathological changes of non-alcoholic fatty liver disease. Dig Dis Sci (2008) 0.99
Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury. Shock (2013) 0.93
Hepatic stellate cells and innate immunity in alcoholic liver disease. World J Gastroenterol (2011) 0.89
Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis. Int J Mol Sci (2013) 0.89
Chronic-alcohol-abuse-induced oxidative stress in the development of acute respiratory distress syndrome. ScientificWorldJournal (2012) 0.88
Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. World J Gastroenterol (2014) 0.87
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH). Semin Immunopathol (2013) 0.87
What does irritable bowel syndrome share with non-alcoholic fatty liver disease? World J Gastroenterol (2013) 0.85
A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnol Bioeng (2011) 0.84
Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. Dis Model Mech (2015) 0.84
Liver fibrogenesis in non-alcoholic steatohepatitis. Front Physiol (2012) 0.83
Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. J Hepatol (2014) 0.82
Macrophages an£1 Alcohol-Related Liver Inflammation. Alcohol Res (2015) 0.80
Prognostic Significance of the Systemic Inflammatory and Immune Balance in Alcoholic Liver Disease with a Focus on Gender-Related Differences. PLoS One (2015) 0.80
Focus on: Alcohol and the liver. Alcohol Res Health (2010) 0.80
Modeling toxicodynamic effects of trichloroethylene on liver in mouse model of autoimmune hepatitis. Toxicol Appl Pharmacol (2014) 0.79
Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses. Alcohol Clin Exp Res (2014) 0.79
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. PLoS One (2013) 0.79
Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells. Am J Physiol Lung Cell Mol Physiol (2014) 0.78
Involvement of hepatic innate immunity in alcoholic liver disease. Immune Netw (2010) 0.78
Estrogen suppresses heptatic IκB expression during short-term alcohol exposure. Inflamm Res (2012) 0.78
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. Int J Mol Sci (2016) 0.77
Animal Models Correlating Immune Cells for the Development of NAFLD/NASH. J Clin Exp Hepatol (2015) 0.77
The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology (2017) 0.77
Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease? World J Gastroenterol (2016) 0.76
Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond. World J Hepatol (2015) 0.76
Alcoholic hepatitis: The pivotal role of Kupffer cells. World J Gastrointest Pathophysiol (2015) 0.75
Dietary saturated fatty acids reduce hepatic lipid accumulation but induce fibrotic change in alcohol-fed rats. Hepatobiliary Surg Nutr (2015) 0.75
Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice. PLoS One (2016) 0.75
Carbohydrate Deficient Transferrin and Interleukin-6 as Predictors of Fibrosis in Alcohol Cirrhosis. Indian J Clin Biochem (2015) 0.75
Targeting inflammation for the treatment of alcoholic liver disease. Pharmacol Ther (2017) 0.75
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest (2005) 4.55
The global burden of liver disease: the major impact of China. Hepatology (2014) 4.23
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology (2004) 3.84
Energy balanced strategies for maximizing the lifetime of sparsely deployed underwater acoustic sensor networks. Sensors (Basel) (2009) 3.74
Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology (2015) 3.10
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology (2006) 3.03
Host factors and failure of interferon-alpha treatment in hepatitis C virus. Hepatology (2004) 2.93
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab (2008) 2.91
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
ECS: efficient communication scheduling for underwater sensor networks. Sensors (Basel) (2011) 2.74
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol (2010) 2.72
Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology (2010) 2.40
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest (2002) 2.40
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol (2009) 2.17
Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers. PLoS One (2011) 2.17
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation (2004) 2.15
Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc (2013) 2.14
Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08
HfOx-based vertical resistive switching random access memory suitable for bit-cost-effective three-dimensional cross-point architecture. ACS Nano (2013) 2.05
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest (2006) 2.03
In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology (2003) 2.00
Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J (2007) 1.94
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology (2008) 1.90
Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice. Hepatology (2010) 1.82
STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology (2006) 1.80
Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology (2013) 1.78
Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology (2007) 1.77
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology (2007) 1.75
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology (2009) 1.72
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem (2003) 1.70
Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int J Biol Sci (2011) 1.70
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression. Hepatology (2011) 1.69
Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol (2004) 1.64
Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (2010) 1.63
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62
Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology (2012) 1.61
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology (2009) 1.61
Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59
Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin. Hepatology (2013) 1.58
A low energy oxide-based electronic synaptic device for neuromorphic visual systems with tolerance to device variation. Adv Mater (2013) 1.57
Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology (2004) 1.54
The complement system in liver diseases. Cell Mol Immunol (2006) 1.54
Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem (2012) 1.53
Inflammation in alcoholic liver disease. Annu Rev Nutr (2012) 1.49
Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes. Gastroenterology (2002) 1.48
A review of catalysts for the electroreduction of carbon dioxide to produce low-carbon fuels. Chem Soc Rev (2014) 1.47
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A (2009) 1.46
Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study. Neurosci Bull (2013) 1.46
IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol (2004) 1.42
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J Leukoc Biol (2007) 1.39
Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free Radic Biol Med (2009) 1.38
Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res (2011) 1.35
Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology (2009) 1.34
Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol (2007) 1.34
Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol (2003) 1.34
IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3. Biochem Biophys Res Commun (2005) 1.33
Natural killer cells in liver disease. Hepatology (2013) 1.31
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology (2008) 1.30
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol (2008) 1.27
Th17 cells and their associated cytokines in liver diseases. Cell Mol Immunol (2010) 1.25
Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther (2008) 1.24
Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology (2004) 1.23
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology (2013) 1.23
The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. J Biol Chem (2012) 1.23
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Lab Invest (2007) 1.22
Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau. Nat Commun (2013) 1.20
Definition of human autoimmunity--autoantibodies versus autoimmune disease. Autoimmun Rev (2009) 1.20
STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice. Hepatology (2006) 1.19
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proc Natl Acad Sci U S A (2013) 1.19
Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes (2005) 1.18
CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br J Pharmacol (2010) 1.18
Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology (2012) 1.17
Involvement of natural killer cells in PolyI:C-induced liver injury. J Hepatol (2004) 1.17
Interferon-lambda (IFN-λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes. J Leukoc Biol (2012) 1.17