Published in World J Gastroenterol on May 28, 2011
Mechanisms and biomarkers of apoptosis in liver disease and fibrosis. Int J Hepatol (2012) 1.02
The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals. Environ Sci Technol (2015) 0.90
Bench-to-beside review: acute-on-chronic liver failure - linking the gut, liver and systemic circulation. Crit Care (2011) 0.87
Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent. PLoS One (2013) 0.81
Fibrogenesis in alcoholic liver disease. World J Gastroenterol (2014) 0.80
Increased occurrence of native septic arthritis in adult cirrhotic patients: a population-based three-year follow-up study in Taiwan. Prz Gastroenterol (2014) 0.76
Hepatic non-parenchymal cells: Master regulators of alcoholic liver disease? World J Gastroenterol (2016) 0.76
Adipose tissue-liver axis in alcoholic liver disease. World J Gastrointest Pathophysiol (2016) 0.75
Intratumoral hepatic stellate cells as a poor prognostic marker and a new treatment target for hepatocellular carcinoma. PLoS One (2013) 0.75
An annual topic highlight: alcohol and liver, 2011. World J Gastroenterol (2011) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Liver fibrosis. J Clin Invest (2005) 17.27
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med (1997) 14.51
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev (2008) 10.28
TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med (2007) 9.77
Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04
Alcoholic liver disease. Hepatology (2010) 5.04
Global challenges in liver disease. Hepatology (2006) 4.55
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med (2006) 4.36
The liver as a lymphoid organ. Annu Rev Immunol (2009) 4.03
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology (2000) 3.97
The liver as an immunological organ. Hepatology (2006) 3.86
Toll-like receptors and adaptor molecules in liver disease: update. Hepatology (2008) 3.72
Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity (2007) 3.61
Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology (2003) 3.51
Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol (2004) 3.27
Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology (1999) 3.24
Liver: An organ with predominant innate immunity. Hepatology (2008) 3.13
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology (2006) 3.03
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology (2008) 2.99
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab (2008) 2.91
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol (2004) 2.78
Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology (2001) 2.72
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest (2000) 2.67
The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology (2004) 2.50
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology (2003) 2.45
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology (2003) 2.40
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem (2002) 2.40
Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem (1998) 2.37
Cytokines in alcoholic liver disease. Semin Liver Dis (1999) 2.37
High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes (2008) 2.23
Innate and adaptive lymphoid cells in the human liver. Immunol Rev (2000) 2.15
Anandamide induces necrosis in primary hepatic stellate cells. Hepatology (2005) 1.98
Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology (2011) 1.98
Consequences of alcohol consumption on host defence. Alcohol Alcohol (2000) 1.97
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology (2005) 1.95
Toll-like receptor signaling in the liver. Gastroenterology (2006) 1.94
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology (2008) 1.90
Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology (2003) 1.86
Transforming growth factor beta and the liver. Hepatology (2001) 1.83
Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology (1996) 1.83
Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) (2003) 1.82
STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology (2006) 1.80
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J Biol Chem (2005) 1.80
Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J Hepatol (1998) 1.76
Steatosis: co-factor in other liver diseases. Hepatology (2005) 1.76
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology (2007) 1.75
Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells. Hepatology (1997) 1.74
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology (2006) 1.71
Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med (1994) 1.71
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology (2009) 1.61
Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med (1990) 1.60
Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59
Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J Leukoc Biol (2006) 1.56
Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology (2004) 1.54
Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology (2007) 1.50
Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology (2006) 1.50
TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp Biol Med (Maywood) (2007) 1.50
Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem (2002) 1.43
Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6. J Virol (2006) 1.38
Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res (1996) 1.36
NK and NKT cells in liver injury and fibrosis. Clin Immunol (2008) 1.35
Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol (2007) 1.34
Structure and function of hepatic stellate cells. Med Electron Microsc (2004) 1.34
Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology (2004) 1.31
Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. J Biol Chem (1985) 1.30
IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cell Mol Immunol (2004) 1.28
Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells. Hepatology (1999) 1.27
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J (2007) 1.26
The endocannabinoid signalling system: biochemical aspects. Pharmacol Biochem Behav (2005) 1.25
Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Hepatology (2006) 1.25
Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS One (2009) 1.25
Hepatoimmunology: a perspective. Immunol Cell Biol (2002) 1.22
Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem (1998) 1.22
Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology (2004) 1.21
Neutrophilic infiltration in alcoholic hepatitis. Alcohol (2002) 1.19
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem (2006) 1.16
Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. Alcohol Clin Exp Res (1998) 1.15
Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. J Biol Chem (2010) 1.14
Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res (2007) 1.12
Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitis. Alcohol Clin Exp Res (2006) 1.10
Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat (2001) 1.10
Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity. FASEB J (2009) 1.10
Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis (2005) 1.09
The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells. Eur J Cell Biol (2001) 1.09
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology (2010) 1.08
A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J Hepatol (2004) 1.06
Innate immunity and alcoholic liver fibrosis. J Gastroenterol Hepatol (2008) 1.04
Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent. Hepatology (2005) 1.04
Starring stellate cells in liver immunology. Curr Opin Immunol (2007) 1.03
Endocannabinoid receptor CB2 in nonalcoholic fatty liver disease. Liver Int (2007) 1.02
Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. J Hepatol (2000) 0.99
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology (2001) 0.98
Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation. J Hepatol (1997) 0.98
Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood. J Hepatol (2001) 0.97
Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways. Am J Physiol Gastrointest Liver Physiol (2004) 0.95
Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C. Hepatology (2003) 0.94
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A (2010) 3.18
Liver: An organ with predominant innate immunity. Hepatology (2008) 3.13
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology (2009) 1.61
Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem (2003) 1.45
Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res (2011) 1.35
Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol (2007) 1.34
STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice. Hepatology (2006) 1.19
Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. J Biol Chem (2010) 1.14
Retinoic acids and hepatic stellate cells in liver disease. J Gastroenterol Hepatol (2012) 1.05
CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice. Hepatology (2012) 1.01
Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis. World J Gastroenterol (2005) 0.94
Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice. J Hepatol (2012) 0.92
Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis. Expert Rev Gastroenterol Hepatol (2007) 0.91
Interaction of hepatic stellate cells with diverse types of immune cells: foe or friend? J Gastroenterol Hepatol (2013) 0.88
Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice. Hepatology (2014) 0.87
Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. PLoS One (2013) 0.86
Diagnostic evaluation of carbon tetrachloride-induced rat hepatic cirrhosis model. Anticancer Res (2005) 0.84
p53 and cell-cycle-regulated protein expression in small intestinal cells after fast-neutron irradiation in mice. Mol Cell Biochem (2005) 0.79
Involvement of hepatic innate immunity in alcoholic liver disease. Immune Netw (2010) 0.78
Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells. Hepatology (2015) 0.78
The protective effect of ENA Actimineral resource A on CCl4-induced liver injury in rats. Mar Biotechnol (NY) (2010) 0.78
Heavy water labeling method for measuring the effect of genistein on mammary gland carcinogenesis. Mol Cell Biochem (2007) 0.77
Primary hepatocyte imaging by multiphoton luminescent graphene quantum dots. Chem Commun (Camb) (2015) 0.77
Proteome analysis by bio-active ceramic water in rat liver: contribution to antioxidant enzyme expression, SOD I. Biochem Biophys Res Commun (2004) 0.75
Up-regulation of Metabotropic glutamate receptor 3 (mGluR3) in rat fibrosis and cirrhosis model of persistent hypoxic condition. Mol Cell Biochem (2006) 0.75
Cytotoxic effects of the conjugated linoleic acid isomers t10c12, c9t11-CLA and mixed form on rat hepatic stellate cells and CCl4-induced hepatic fibrosis. J Nutr Biochem (2007) 0.75
Effects of bio-active ceramic resources in cutaneous wound healing and the role of TGF-beta signaling. Mol Cell Biochem (2006) 0.75
ENA Actimineral Resource A restores bone loss and bone quality in ovariectomized rats. Mol Cell Biochem (2006) 0.75
Protective effects of bio-active ceramic water on alcohol-induced hepatic injury in pigs. J Vet Med Sci (2005) 0.75