PubRank

Hiroaki Sakurai

Author PubWeight™ 108.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 2006 4.01
2 Preparation, adsorption properties, and catalytic activity of 3D porous metal-organic frameworks composed of cubic building blocks and alkali-metal ions. Angew Chem Int Ed Engl 2006 2.35
3 Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem 2001 2.21
4 Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 2004 2.11
5 Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 2003 1.91
6 A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine. Evid Based Complement Alternat Med 2007 1.77
7 Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 2006 1.68
8 Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol 2003 1.63
9 Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal 2009 1.61
10 Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol 2006 1.60
11 PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med 2005 1.57
12 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J 2007 1.54
13 Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol 2002 1.53
14 Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis 2004 1.46
15 High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res 2007 1.32
16 TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem 2005 1.28
17 IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. FASEB J 2005 1.27
18 Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. Eur J Cancer 2008 1.21
19 A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep 2008 1.21
20 RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin Exp Metastasis 2006 1.17
21 ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model. Mol Cancer Ther 2003 1.12
22 Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci 2005 1.11
23 The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep 2006 1.10
24 TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. Mol Cell Biol 2009 1.09
25 Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice. Cancer Lett 2004 1.08
26 Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov. Bioorg Med Chem Lett 2007 1.06
27 Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells. Int J Cancer 2008 1.06
28 SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol Rep 2012 1.04
29 Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Mol Cancer Ther 2006 1.03
30 Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells. Eur J Cancer 2007 0.99
31 Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. Cancer Sci 2006 0.98
32 Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways. Int J Oncol 2011 0.97
33 Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-alpha through the TAK1-p38 signaling pathway. J Biol Chem 2007 0.96
34 Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J Biol Chem 2007 0.96
35 Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization. Cancer Sci 2007 0.96
36 Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption. J Immunol 2009 0.94
37 CCL21 promotes the migration and adhesion of highly lymph node metastatic human non-small cell lung cancer Lu-99 in vitro. Oncol Rep 2007 0.94
38 Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9. J Biol Chem 2011 0.93
39 Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp. J Antibiot (Tokyo) 2012 0.93
40 Au@ZIF-8: CO oxidation over gold nanoparticles deposited to metal-organic framework. J Am Chem Soc 2009 0.92
41 Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages. Int Immunopharmacol 2005 0.90
42 A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep 2013 0.89
43 TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells. Int J Cancer 2006 0.88
44 Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Mol Cell Biochem 2010 0.88
45 Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability. Am J Pathol 2008 0.88
46 Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. J Biol Chem 2009 0.88
47 Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861. J Antibiot (Tokyo) 2006 0.87
48 Pharmaceutical evaluation of liquorice before and after roasting in mice. J Pharm Pharmacol 2004 0.87
49 Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis. Clin Cancer Res 2011 0.87
50 Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells. Helicobacter 2009 0.86
51 Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B. Cancer Sci 2014 0.86
52 Abyssomicin I, a modified polycyclic polyketide from Streptomyces sp. CHI39. J Nat Prod 2010 0.86
53 Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol 2013 0.86
54 Stimulation of cultured colon 26 cells with TNF-alpha promotes lung metastasis through the extracellular signal-regulated kinase pathway. Cancer Lett 2005 0.86
55 Tuning of protein kinase circuitry by p38α is vital for epithelial tissue homeostasis. J Biol Chem 2013 0.86
56 Severe pulmonary metastasis in obese and diabetic mice. Int J Cancer 2006 0.85
57 Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways. Int J Oncol 2011 0.85
58 Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiers. Org Lett 2011 0.85
59 Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model. Oncol Rep 2012 0.85
60 Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta 2009 0.84
61 Suppression of cell invasiveness by periostin via TAB1/TAK1. Int J Oncol 2009 0.84
62 Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp. J Antibiot (Tokyo) 2010 0.84
63 Prevention of intrahepatic metastasis by curcumin in an orthotopic implantation model. Oncology 2003 0.83
64 Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients. Clin Biochem 2007 0.83
65 Cochinin B, a novel ribosome-inactivating protein from the seeds of Momordica cochinchinensis. Biol Pharm Bull 2007 0.83
66 Telomerase upregulates expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and granulocyte-macrophage colony-stimulating factor in normal human fibroblasts. Biochem Biophys Res Commun 2003 0.83
67 Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation. In Vivo 2010 0.83
68 A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity. PLoS One 2012 0.83
69 Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity. Lymphat Res Biol 2009 0.83
70 Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein. Biol Pharm Bull 2012 0.82
71 Brartemicin, an inhibitor of tumor cell invasion from the actinomycete Nonomuraea sp. J Nat Prod 2009 0.82
72 Novel inhibitor for fibroblast growth factor receptor tyrosine kinase. Bioorg Med Chem Lett 2007 0.82
73 E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity. J Biol Chem 2010 0.81
74 Inhibition of NF-kappaB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells. Int J Mol Med 2010 0.81
75 RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer. Cancer Sci 2014 0.81
76 RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells. Biochem Biophys Res Commun 2007 0.81
77 CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer 2014 0.81
78 Expression patterns of plasma proteins in spontaneously diabetic rats after oral administration of a Kampo medicine, Hachimi-jio-gan, using SELDI ProteinChip platform. Biol Pharm Bull 2005 0.81
79 Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line. Int J Oncol 2013 0.81
80 Urinary trypsin inhibitor suppresses surgical stress-facilitated lung metastasis of murine colon 26-L5 carcinoma cells. Anticancer Res 2005 0.81
81 Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells. Cancer Lett 2007 0.81
82 Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer. Front Biosci (Schol Ed) 2012 0.79
83 Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1. Biosci Biotechnol Biochem 2008 0.79
84 Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1. PLoS One 2011 0.79
85 Anti-tumor effect of combining CC chemokine 22 and an anti-CD25 antibody on myeloma cells implanted subcutaneously into mice. Mol Med Rep 2011 0.79
86 An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun 2009 0.79
87 Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation. Cancer Sci 2013 0.79
88 Synthesis and evaluation of myxochelin analogues as antimetastatic agents. Bioorg Med Chem 2009 0.78
89 Validity study of the standing test for imbalance and disequilibrium (SIDE): Is the amount of body sway in adopted postures consistent with item order? Gait Posture 2011 0.78
90 Proteomic identification of haptoglobin as a stroke plasma biomarker in spontaneously hypertensive stroke-prone rats. Life Sci 2008 0.78
91 eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells. Lymphat Res Biol 2011 0.77
92 Cytotoxic cardiac glycosides from the roots of Streptocaulon juventas. Planta Med 2012 0.77
93 MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells. Cancer Lett 2006 0.77
94 Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5. Int J Oncol 2011 0.77
95 Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2. FEBS Lett 2006 0.77
96 Industrial production of difructose anhydride III (DFA III) from crude inulin extracted from chicory roots using Arthrobacter sp. H65-7 fructosyltransferase. J Biosci Bioeng 2009 0.77
97 Probing the Lewis acid sites and CO catalytic oxidation activity of the porous metal-organic polymer [Cu(5-methylisophthalate)]. J Am Chem Soc 2007 0.77
98 TGF-β-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-κB, p38 MAPK and ERK phosphorylations. Radiat Res 2012 0.77
99 Unusual regenerable porous metal-organic framework based on a new triple helical molecular necklace for separating organosulfur compounds. Chemistry 2012 0.76
100 Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation. J Nat Med 2014 0.76
101 Enzymatic and biochemical properties of a novel human serine dehydratase isoform. Biochim Biophys Acta 2006 0.76
102 5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases. Bioorg Med Chem Lett 2008 0.76
103 A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells. Biol Pharm Bull 2006 0.76
104 Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation. Hum Cell 2012 0.76
105 A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells. Biol Pharm Bull 2010 0.76
106 TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress. Int J Hyperthermia 2013 0.76
107 Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model. Evid Based Complement Alternat Med 2011 0.75
108 Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. Int J Oncol 2014 0.75
109 A newly devised formulation for self-medication enhances interferon-gamma production and proliferation of splenic lymphocytes. Biol Pharm Bull 2005 0.75
110 Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives. Bioorg Med Chem Lett 2009 0.75
111 TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma. Cancer Lett 2003 0.75
112 Estimations of One Repetition Maximum and Isometric Peak Torque in Knee Extension Based on the Relationship Between Force and Velocity. J Strength Cond Res 2016 0.75
113 Iodine-catalyzed etherification of morroniside. Chem Pharm Bull (Tokyo) 2009 0.75
114 Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD(+)-dependent histone deacetylase inhibitor. Org Lett 2012 0.75
115 Time-dependent effects of neuromuscular electrical stimulation on changes in spinal excitability are dependent on stimulation frequency: a preliminary study in healthy adults. Somatosens Mot Res 2014 0.75
116 Endoplasmic Reticulum Stress Response and Mutant Protein Degradation in CHO Cells Accumulating Antithrombin (C95R) in Russell Bodies. Biol Pharm Bull 2015 0.75
117 Benzophenones from an endophytic fungus, Graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor. Org Lett 2013 0.75
118 One-pot conversion of levan prepared from Serratia levanicum NN to difructose anhydride IV by Arthrobacter nicotinovorans levan fructotransferase. J Biosci Bioeng 2009 0.75
119 [Regulation of receptor tyrosine kinases by Ser/Thr phosphorylation]. Seikagaku 2013 0.75