Published in EMBO J on March 15, 2007
Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat Immunol (2009) 3.63
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J (2007) 2.16
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature (2008) 1.91
NF-κB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res (2010) 1.58
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev (2009) 1.44
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell (2008) 1.41
Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. Am J Physiol Lung Cell Mol Physiol (2009) 1.40
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol (2008) 1.30
Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. Cytokine (2009) 1.28
The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. Mol Cell Biol (2008) 1.26
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A (2008) 1.20
Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain. Biochemistry (2010) 1.16
Regulation of NF-κB by the CARD proteins. Immunol Rev (2012) 1.12
A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol (2012) 1.06
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med (2013) 1.02
Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl. Mol Cancer (2010) 1.00
NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J Biol Chem (2010) 1.00
Regulation of NF-κB induction by TCR/CD28. Immunol Res (2011) 0.99
Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens (2008) 0.99
The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN. Mol Cell (2010) 0.98
A new look at T cell receptor signaling to nuclear factor-κB. Trends Immunol (2013) 0.97
Akt fine-tunes NF-κB-dependent gene expression during T cell activation. J Biol Chem (2011) 0.97
Structural insights into the assembly of CARMA1 and BCL10. PLoS One (2012) 0.97
Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives? Cell Signal (2009) 0.96
The immunological synapse. Cancer Immunol Res (2014) 0.93
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression. Immunology (2010) 0.91
The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling. PLoS One (2010) 0.91
Molecular basis of lysophosphatidic acid-induced NF-κB activation. Cell Signal (2010) 0.89
K63-linked ubiquitination in kinase activation and cancer. Front Oncol (2012) 0.87
CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases. World J Biol Chem (2010) 0.86
Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ. Biochim Biophys Acta (2014) 0.86
Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax. Cell Biosci (2011) 0.85
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin. Mol Cancer (2014) 0.84
Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection. J Biol Chem (2012) 0.84
Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-κB activation following carrageenan. Am J Physiol Gastrointest Liver Physiol (2011) 0.83
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. PLoS One (2015) 0.83
The role of CARMA1 in T cells. Crit Rev Immunol (2013) 0.81
Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway. J Biol Chem (2011) 0.81
MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene (2015) 0.79
B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model. Cell Commun Signal (2011) 0.78
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway. Am J Pathol (2016) 0.78
Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP). J Biol Chem (2016) 0.76
The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts. Br J Pharmacol (2014) 0.76
Bupivacaine effectively relieves inflammation-induced pain by suppressing activation of the NF-κB signalling pathway and inhibiting the activation of spinal microglia and astrocytes. Exp Ther Med (2017) 0.75
PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1. PLoS One (2012) 0.75
The CBM signalosome: potential therapeutic target for aggressive lymphoma? Cytokine Growth Factor Rev (2013) 0.75
Bindarit reduces the incidence of acute aortic dissection complicated lung injury via modulating NF-κB pathway. Exp Ther Med (2017) 0.75
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol (2000) 20.70
Signaling to NF-kappaB. Genes Dev (2004) 19.78
Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 14.14
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell (1998) 6.48
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature (1998) 6.15
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 5.48
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell (2004) 5.08
The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94
The immunological synapse. Annu Rev Immunol (2001) 4.45
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature (2003) 3.96
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science (2005) 3.74
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity (2005) 3.36
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science (2003) 3.28
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem (2003) 3.19
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.16
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity (2005) 3.14
Antigen-receptor signaling to nuclear factor kappa B. Immunity (2006) 3.07
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65
Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity (2003) 2.63
Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol (2003) 2.51
Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A (2006) 2.19
A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem (2003) 2.12
Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes. Curr Biol (2003) 2.04
CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol (2004) 1.96
Ubiquitin, TAK1 and IKK: is there a connection? Cell Death Differ (2006) 1.82
Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol (2003) 1.70
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med (2005) 1.57
The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol (2004) 1.54
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem (2004) 1.38
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 1.35
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol (2002) 1.33
Membrane compartmentation and the response to antigen. Curr Opin Immunol (1999) 1.15
Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. J Biol Chem (2004) 1.12
T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse. Immunol Lett (2004) 1.06
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol (2008) 4.66
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol (2007) 4.11
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol (2006) 4.01
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem (2006) 3.51
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity (2005) 3.14
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90
E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol (2009) 2.79
Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol (2010) 2.70
Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol (2005) 2.56
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol (2010) 2.47
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity (2011) 2.39
Preparation, adsorption properties, and catalytic activity of 3D porous metal-organic frameworks composed of cubic building blocks and alkali-metal ions. Angew Chem Int Ed Engl (2006) 2.35
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem (2006) 2.32
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol (2009) 2.23
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem (2001) 2.21
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J Natl Cancer Inst (2008) 2.21
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A (2010) 2.20
Evaluation of terrestrial carbon cycle models for their response to climate variability and to CO2 trends. Glob Chang Biol (2013) 2.13
Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02
The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology (2013) 2.02
CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol (2004) 1.96
Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun (2003) 1.91
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol (2009) 1.84
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20. J Mol Biol (2007) 1.82
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor. J Biol Chem (2003) 1.81
A Proteomic Approach for the Diagnosis of 'Oketsu' (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine. Evid Based Complement Alternat Med (2007) 1.77
Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17. J Biol Chem (2004) 1.77
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res (2006) 1.68
Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog (2012) 1.68
Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol (2002) 1.68
Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. Am J Hypertens (2011) 1.67
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol (2003) 1.63
Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal (2009) 1.61
Cutting edge: TLR2 directly triggers Th1 effector functions. J Immunol (2007) 1.61
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol (2006) 1.60
Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry (2009) 1.60
NF-κB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res (2010) 1.58
Evidence of recombination and genetic diversity in human rhinoviruses in children with acute respiratory infection. PLoS One (2009) 1.58
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med (2005) 1.57
TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem (2006) 1.56
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med (2007) 1.55
Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes (2004) 1.54
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53
Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation. Cytokine (2008) 1.50
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem (2008) 1.48
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. J Hypertens (2012) 1.47
C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity (2013) 1.46
Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells. Carcinogenesis (2004) 1.46
Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A (2006) 1.46
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Hum Mol Genet (2004) 1.46
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol Cell Biol (2008) 1.46
The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood (2005) 1.46
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev (2007) 1.45
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev (2009) 1.44
Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A (2006) 1.44
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity (2006) 1.40
The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med (2005) 1.39
Declining snow cover may affect spring phenological trend on the Tibetan Plateau. Proc Natl Acad Sci U S A (2013) 1.38
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem (2004) 1.38
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol (2002) 1.36
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest (2010) 1.35
Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (2013) 1.35
High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer. Cancer Res (2007) 1.32
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun (2007) 1.30
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem (2005) 1.28
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. FASEB J (2005) 1.27
High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Cancer Epidemiol Biomarkers Prev (2007) 1.27
Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry (2010) 1.27