|
1
|
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.
|
Proc Natl Acad Sci U S A
|
2002
|
2.24
|
|
2
|
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.
|
Pain
|
2006
|
1.55
|
|
3
|
A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.
|
Biochem Pharmacol
|
2007
|
1.27
|
|
4
|
Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.
|
Behav Brain Res
|
2005
|
1.25
|
|
5
|
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.
|
Pain
|
2002
|
1.08
|
|
6
|
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.
|
Pain
|
2011
|
0.96
|
|
7
|
Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
|
J Med Chem
|
2007
|
0.91
|
|
8
|
A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.
|
J Neurosci Methods
|
2006
|
0.89
|
|
9
|
[3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors.
|
J Pharmacol Exp Ther
|
2004
|
0.85
|
|
10
|
Potent desensitization of human P2X3 receptors by diadenosine polyphosphates.
|
Eur J Pharmacol
|
2002
|
0.78
|
|
11
|
Characterization of human ASIC2a homomeric channels stably expressed in murine Ltk- cells.
|
Life Sci
|
2007
|
0.76
|