Published in Genomics on October 27, 2005
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol (2009) 2.17
Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev (2010) 2.04
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science (2013) 1.76
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
A recombineering based approach for high-throughput conditional knockout targeting vector construction. Nucleic Acids Res (2007) 1.63
Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice. Genome Biol (2008) 1.44
Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood (2011) 1.41
An olfactory subsystem that mediates high-sensitivity detection of volatile amines. Cell Rep (2012) 1.30
RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28
Developmental origins of central norepinephrine neuron diversity. Nat Neurosci (2013) 1.19
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet (2009) 1.16
Nonmuscle myosin II isoform and domain specificity during early mouse development. Proc Natl Acad Sci U S A (2010) 1.16
Contemporary approaches for modifying the mouse genome. Physiol Genomics (2008) 1.10
Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes. Genomics (2009) 1.10
The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Genes Dev (2015) 1.07
Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. J Biol Chem (2011) 1.06
The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05
Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol (2006) 1.05
The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod (2011) 1.04
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol (2013) 1.00
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun (2016) 0.97
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J (2012) 0.92
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. PLoS One (2015) 0.89
Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology (2009) 0.86
Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol (2014) 0.86
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis. Cell Death Differ (2015) 0.86
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. J Cell Biol (2014) 0.85
Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. PLoS Genet (2013) 0.84
Identification and characterization of RBM44 as a novel intercellular bridge protein. PLoS One (2011) 0.81
Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain. Front Cell Neurosci (2015) 0.81
Genetic manipulation of the Toxoplasma gondii genome by fosmid recombineering. MBio (2014) 0.81
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun (2016) 0.81
Interaction of Salmonella typhimurium with dendritic cells derived from pluripotent embryonic stem cells. PLoS One (2012) 0.80
Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS One (2012) 0.80
Stella-Cre mice are highly efficient Cre deleters. Genesis (2011) 0.80
Modeling partial monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition. PLoS One (2012) 0.80
Keratins and protein synthesis: the plot thickens. J Cell Biol (2009) 0.78
Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. Mol Cell Endocrinol (2009) 0.78
Global deletion of Ankrd1 results in a wound-healing phenotype associated with dermal fibroblast dysfunction. Am J Pathol (2014) 0.77
A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells. Methods Mol Biol (2013) 0.76
The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol (2015) 0.76
A BAC-based transgenic mouse specifically expresses an inducible Cre in the urothelium. PLoS One (2012) 0.75
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. J Neurophysiol (2015) 0.75
The generation of knock-in mice expressing fluorescently tagged galanin receptors 1 and 2. Mol Cell Neurosci (2015) 0.75
A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus). PLoS One (2013) 0.75
Generating tamoxifen-inducible Cre alleles to investigate myogenesis in mice. Methods Mol Biol (2012) 0.75
Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1. BMC Genomics (2011) 0.75
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem (2017) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature (2008) 18.84
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16
Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63
Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature (2009) 13.45
Evolution of MRSA during hospital transmission and intercontinental spread. Science (2010) 13.34
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med (2013) 13.22
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Prepublication data sharing. Nature (2009) 12.24
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Population genomics of domestic and wild yeasts. Nature (2009) 11.79
The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes. Nat Methods (2009) 10.41
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet (2003) 9.13
Rapid pneumococcal evolution in response to clinical interventions. Science (2011) 9.09
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A (2004) 8.95
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell (2006) 8.09
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet (2006) 8.02
A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol (2008) 7.95
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
The knockout mouse project. Nat Genet (2004) 7.80
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 7.42
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A (2004) 7.30
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res (2007) 6.91
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect Dis (2012) 6.64
Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J Antimicrob Chemother (2003) 6.59
Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes. PLoS Genet (2006) 6.43
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet (2012) 6.25
A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science (2005) 5.99
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature (2009) 5.90
Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi. J Bacteriol (2007) 5.88
Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Curr Biol (2009) 5.70
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
The genome of the protist parasite Entamoeba histolytica. Nature (2005) 5.33
Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units. Sci Transl Med (2012) 5.16
Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98
A physical map of the mouse genome. Nature (2002) 4.97
The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics (2007) 4.62
Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet (2007) 4.58
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell (2010) 4.47
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature (2012) 4.37
Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res (2007) 4.33
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87
The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol (2008) 3.85
Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database. Nucleic Acids Res (2007) 3.84
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Genome plasticity of BCG and impact on vaccine efficacy. Proc Natl Acad Sci U S A (2007) 3.73
Genome variation and evolution of the malaria parasite Plasmodium falciparum. Nat Genet (2006) 3.68
Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol (2009) 3.66
Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood (2012) 3.63
Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biol (2009) 3.63
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res (2005) 3.63
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell (2010) 3.60