Published in PLoS Biol on January 01, 2008
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
Epigenetics in cancer. Carcinogenesis (2009) 7.49
DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Distinctive chromatin in human sperm packages genes for embryo development. Nature (2009) 6.18
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell (2010) 5.43
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
A human B cell methylome at 100-base pair resolution. Proc Natl Acad Sci U S A (2009) 4.72
Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet (2010) 4.27
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet (2011) 3.99
Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol (2009) 3.96
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet (2010) 3.38
Factors underlying variable DNA methylation in a human community cohort. Proc Natl Acad Sci U S A (2012) 3.20
Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA. Nucleic Acids Res (2009) 3.09
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res (2009) 2.87
CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
DNA methylation is widespread and associated with differential gene expression in castes of the honeybee, Apis mellifera. Proc Natl Acad Sci U S A (2009) 2.77
Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev (2009) 2.76
DNA methylation dynamics in health and disease. Nat Struct Mol Biol (2013) 2.58
Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res (2011) 2.51
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet (2009) 2.37
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21
The genome sequence of the leaf-cutter ant Atta cephalotes reveals insights into its obligate symbiotic lifestyle. PLoS Genet (2011) 2.16
An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect (2010) 2.16
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res (2013) 2.07
A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet (2015) 2.04
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
Genome-scale approaches to the epigenetics of common human disease. Virchows Arch (2009) 2.02
DNA methylation status predicts cell type-specific enhancer activity. EMBO J (2011) 1.98
A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues. PLoS Genet (2011) 1.92
Heterogeneity in white blood cells has potential to confound DNA methylation measurements. PLoS One (2012) 1.91
DNA methylation and demethylation in mammals. J Biol Chem (2011) 1.89
Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. Br J Cancer (2010) 1.86
DNA methylation dynamics during the mammalian life cycle. Philos Trans R Soc Lond B Biol Sci (2013) 1.85
Epigenetic mechanisms in mammals. Cell Mol Life Sci (2009) 1.82
DNA methylation and cellular reprogramming. Trends Cell Biol (2010) 1.77
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Epigenetics Chromatin (2013) 1.62
Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation. Hum Genet (2011) 1.60
The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin (2009) 1.59
CpG island hypermethylation in human astrocytomas. Cancer Res (2010) 1.57
Dynamic changes in histone modifications precede de novo DNA methylation in oocytes. Genes Dev (2015) 1.56
Genome-wide survey reveals dynamic widespread tissue-specific changes in DNA methylation during development. BMC Genomics (2011) 1.56
miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol (2011) 1.55
Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51
Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One (2011) 1.50
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome. Dev Cell (2012) 1.47
Epigenome mapping in normal and disease States. Circ Res (2010) 1.47
Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res (2009) 1.43
Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development. Genomics (2008) 1.42
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues. Epigenetics (2010) 1.41
Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues. Proc Natl Acad Sci U S A (2010) 1.37
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
CpG island density and its correlations with genomic features in mammalian genomes. Genome Biol (2008) 1.30
Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA. Nucleic Acids Res (2010) 1.26
Methods in DNA methylation profiling. Epigenomics (2009) 1.25
Understanding the relationship between DNA methylation and histone lysine methylation. Biochim Biophys Acta (2014) 1.23
LSH and G9a/GLP complex are required for developmentally programmed DNA methylation. Genome Res (2010) 1.21
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation. Genome Biol (2014) 1.19
Tissue-specific variation in DNA methylation levels along human chromosome 1. Epigenetics Chromatin (2009) 1.19
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. J Clin Invest (2014) 1.18
Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One (2010) 1.17
Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. PLoS One (2009) 1.14
CpG islands: algorithms and applications in methylation studies. Biochem Biophys Res Commun (2009) 1.13
The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics (2011) 1.13
Extensive epigenetic reprogramming in human somatic tissues between fetus and adult. Epigenetics Chromatin (2011) 1.13
Prediction of CpG-island function: CpG clustering vs. sliding-window methods. BMC Genomics (2010) 1.12
Human-specific CpG "beacons" identify loci associated with human-specific traits and disease. Epigenetics (2012) 1.07
Epigenetics and epigenetic alterations in pancreatic cancer. Int J Clin Exp Pathol (2008) 1.05
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res (2012) 1.05
Clustering of codons with rare cognate tRNAs in human genes suggests an extra level of expression regulation. PLoS Genet (2009) 1.03
Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates. Genome Res (2011) 1.03
Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. RNA Biol (2014) 1.03
Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychol Med (2012) 1.02
Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. Carcinogenesis (2008) 1.01
Cell-specific DNA methylation patterns of retina-specific genes. PLoS One (2012) 1.00
Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome. Nucleic Acids Res (2015) 1.00
Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics (2014) 1.00
CpG_MI: a novel approach for identifying functional CpG islands in mammalian genomes. Nucleic Acids Res (2009) 0.98
Hormonally mediated epigenetic changes to steroid receptors in the developing brain: implications for sexual differentiation. Horm Behav (2010) 0.98
DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics (2013) 0.97
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci (2013) 0.97
Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island. BMC Cancer (2013) 0.97
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res (2009) 0.97
Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell (2016) 0.96
Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res (1998) 96.63
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet (2000) 69.26
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell (1992) 27.80
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Repbase Update, a database of eukaryotic repetitive elements. Cytogenet Genome Res (2005) 23.41
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
CpG islands in vertebrate genomes. J Mol Biol (1987) 23.16
PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Global identification of human transcribed sequences with genome tiling arrays. Science (2004) 17.85
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. Cell (2006) 15.24
Stability and flexibility of epigenetic gene regulation in mammalian development. Nature (2007) 14.57
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature (2005) 12.06
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat Genet (2006) 11.88
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A (2006) 10.63
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature (2002) 7.37
Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79
BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing. Bioinformatics (2005) 5.95
A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell (1985) 5.63
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell (1989) 5.12
Imprinted expression of the Igf2r gene depends on an intronic CpG island. Nature (1997) 5.08
Role for DNA methylation in the control of cell type specific maspin expression. Nat Genet (2002) 4.72
Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci U S A (2005) 4.59
Purification of CpG islands using a methylated DNA binding column. Nat Genet (1994) 4.31
DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol (1999) 3.76
X-chromosome inactivation in mammals. Annu Rev Genet (1997) 3.50
A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res (2002) 3.50
Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Mol Cell Biol (2000) 3.44
The CpG island searcher: a new WWW resource. In Silico Biol (2003) 3.42
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
Methylation analysis on individual chromosomes: improved protocol for bisulphite genomic sequencing. Nucleic Acids Res (1994) 2.67
CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure. PLoS Genet (2006) 2.66
A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q. Genome Res (2004) 2.56
Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice. Genes Cells (2002) 2.52
DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev (1996) 2.51
DNA methylation in the Alu sequences of diploid and haploid primary human cells. EMBO J (1993) 2.47
CpG methylation is targeted to transcription units in an invertebrate genome. Genome Res (2007) 2.47
Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J Natl Cancer Inst (2001) 2.13
X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation. Dev Biol (2000) 1.80
MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex. J Biol Chem (2004) 1.79
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol (2004) 1.74
5-Azacytidine-induced reactivation of the human X chromosome-linked PGK1 gene is associated with a large region of cytosine demethylation in the 5' CpG island. Proc Natl Acad Sci U S A (1990) 1.45
An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands. Mol Cell Biol (1998) 1.34
Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene (1999) 1.33
X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Hum Mol Genet (1996) 1.23
The finished DNA sequence of human chromosome 12. Nature (2006) 1.08
Modified guanidinium thiocyanate method for human sperm DNA isolation. Mol Hum Reprod (1997) 0.96
Gene regulation and differentiation in vertebrate ocular tissues. Curr Opin Genet Dev (1994) 0.88
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature (2008) 18.84
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 15.45
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med (2013) 13.22
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Prepublication data sharing. Nature (2009) 12.24
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med (2014) 11.87
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (2005) 8.55
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res (2004) 7.50
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 7.42
Reversal of neurological defects in a mouse model of Rett syndrome. Science (2007) 7.09
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res (2007) 6.91
The multifunctional NS1 protein of influenza A viruses. J Gen Virol (2008) 6.87
Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J Antimicrob Chemother (2003) 6.59
Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood (2013) 6.50
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet (2012) 6.25
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Accurate and reliable high-throughput detection of copy number variation in the human genome. Genome Res (2006) 5.50
Negotiating for change. The healthcare manager as catalyst for evidence-based practice: changing the healthcare environment and sharing experience. Healthc Pap (2003) 5.49
Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units. Sci Transl Med (2012) 5.16
Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98
A physical map of the mouse genome. Nature (2002) 4.97
The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94
CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature (2010) 4.86
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics (2007) 4.62
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res (2007) 4.33
Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors. Lancet Oncol (2006) 4.32
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
Insights into hominid evolution from the gorilla genome sequence. Nature (2012) 4.12
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database. Nucleic Acids Res (2007) 3.84
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet (2012) 3.77
Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol (2006) 3.71
Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns. Blood (2012) 3.63
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics (2003) 3.30
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature (2011) 3.28
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell (2008) 3.25
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Nodulation signaling in legumes requires NSP2, a member of the GRAS family of transcriptional regulators. Science (2005) 3.19
A conserved supergene locus controls colour pattern diversity in Heliconius butterflies. PLoS Biol (2006) 3.15
TranscriptSNPView: a genome-wide catalog of mouse coding variation. Nat Genet (2006) 3.10
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet (2009) 3.05
Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet (2006) 3.00
Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol (2005) 2.90
The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (2011) 2.84
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci. Genome Res (2002) 2.77
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry. Nature (2011) 2.65
A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro. J Neurosci (2008) 2.65
Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A (2006) 2.63