Published in Development on November 01, 2005
Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev (2008) 2.44
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet (2007) 1.97
Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression. Dev Biol (2006) 1.49
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol (2009) 1.46
Transcriptional pathways in second heart field development. Semin Cell Dev Biol (2007) 1.43
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol (2008) 1.35
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. J Med Genet (2009) 1.32
TBX5 is required for embryonic cardiac cell cycle progression. Development (2006) 1.23
The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process. Genes Cancer (2010) 1.23
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet (2013) 1.19
Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature (2009) 1.13
The cardiac conduction system. Circulation (2011) 1.11
The BMP pathway acts to directly regulate Tbx20 in the developing heart. Development (2010) 1.08
Ciona intestinalis as a model for cardiac development. Semin Cell Dev Biol (2006) 1.06
Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation. Dev Biol (2009) 1.04
Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis. Dev Dyn (2009) 1.04
T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. Proc Natl Acad Sci U S A (2009) 1.04
T-box factors determine cardiac design. Cell Mol Life Sci (2007) 1.04
Synergistic activation of cardiac genes by myocardin and Tbx5. PLoS One (2011) 1.02
Genetic basis of congenital cardiovascular malformations. Eur J Med Genet (2014) 1.00
Molecular genetics of congenital atrial septal defects. Clin Res Cardiol (2009) 0.99
Molecular regulation of cardiomyocyte differentiation. Circ Res (2015) 0.98
Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice. Dev Biol (2011) 0.98
Epigenetic factors and cardiac development. Cardiovasc Res (2011) 0.97
Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Dev Biol (2011) 0.97
Midline governs axon pathfinding by coordinating expression of two major guidance systems. Genes Dev (2009) 0.95
Transcriptional regulation of heart valve progenitor cells. Pediatr Cardiol (2009) 0.94
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells. PLoS One (2013) 0.93
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One (2011) 0.92
Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster. Dev Biol (2008) 0.92
Developmental expression patterns of Tbx1, Tbx2, Tbx5, and Tbx20 in Xenopus tropicalis. Dev Dyn (2006) 0.89
Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome. Semin Cell Dev Biol (2006) 0.88
The role of Shox2 in SAN development and function. Pediatr Cardiol (2012) 0.88
Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development. Dev Genes Evol (2006) 0.88
Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem (2014) 0.87
Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd. PLoS One (2012) 0.83
Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development (2015) 0.83
Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochem Biophys Res Commun (2011) 0.83
Genetic and genomic dissection of cardiogenesis in the Drosophila model. Pediatr Cardiol (2009) 0.83
Islet1-expressing cardiac progenitor cells: a comparison across species. Dev Genes Evol (2012) 0.82
Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age. Dev Biol (2012) 0.81
The embryonic genes Dkk3, Hoxd8, Hoxd9 and Tbx1 identify muscle types in a diet-independent and fiber-type unrelated way. BMC Genomics (2010) 0.80
Novel mutations in the transcriptional activator domain of the human TBX20 in patients with atrial septal defect. Biomed Res Int (2015) 0.79
TBX4 mutations (small patella syndrome) are associated with childhood-onset pulmonary arterial hypertension. J Med Genet (2013) 0.79
Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development. Elife (2016) 0.77
Activation of GATA4 gene expression at the early stage of cardiac specification. Front Chem (2014) 0.76
Prevalence and Spectrum of TBX5 Mutation in Patients with Lone Atrial Fibrillation. Int J Med Sci (2016) 0.76
Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase. Mol Med Rep (2016) 0.75
Teed off: cardiac conduction system development requires T-box transcription factors. Circ Res (2008) 0.75
Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS One (2016) 0.75
Tbx20 controls the expression of the KCNH2 gene and of hERG channels. Proc Natl Acad Sci U S A (2017) 0.75
Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet (2002) 7.40
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A (2007) 3.61
Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell (2011) 3.56
Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium. Circ Res (2007) 3.00
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol (2002) 2.30
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development. Dev Cell (2008) 2.15
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet (2007) 1.97
Molecular pathway for the localized formation of the sinoatrial node. Circ Res (2007) 1.93
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol (2003) 1.89
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J Am Coll Cardiol (2003) 1.86
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A (2012) 1.73
Long noncoding RNAs in cardiac development and pathophysiology. Circ Res (2012) 1.72
Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res (2006) 1.70
Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun (2011) 1.69
Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci U S A (2009) 1.68
Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity (2013) 1.62
Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities. Stem Cell Res (2011) 1.45
Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun (2013) 1.36
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. J Med Genet (2009) 1.32
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ Res (2014) 1.29
Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects. Hum Mol Genet (2010) 1.22
Congenital heart disease: current knowledge about causes and inheritance. Med J Aust (2012) 1.21
BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev (2008) 1.12
Molecular pathways in myocardial development: a stem cell perspective. Cardiovasc Res (2003) 1.10
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression. Nat Genet (2007) 1.09
Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium. Circ Res (2010) 1.08
Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One (2010) 1.06
GATA4 mutations in 357 unrelated patients with congenital heart malformation. Genet Test Mol Biomarkers (2010) 1.05
Developmental paradigms in heart disease: insights from tinman. Ann Med (2002) 1.02
A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery. Development (2006) 1.00
Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation (2011) 0.99
Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy. Circ Cardiovasc Genet (2013) 0.98
Cardiovascular regenerative medicine: digging in for the long haul. Cell Stem Cell (2007) 0.98
Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. Neuroreport (2006) 0.96
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol (2011) 0.95
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Dev Cell (2012) 0.94
Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway. Exp Cell Res (2005) 0.93
Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20. J Mol Biol (2009) 0.93
Expression of Slit and Robo genes in the developing mouse heart. Dev Dyn (2010) 0.93
Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations. Congenit Heart Dis (2011) 0.92
Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One (2011) 0.92
Characterization of Pitx2c expression in the mouse heart using a reporter transgene. Dev Dyn (2011) 0.92
c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells. Stem Cells (2009) 0.91
Zac1 is an essential transcription factor for cardiac morphogenesis. Circ Res (2010) 0.91
Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet (2010) 0.90
Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis. Nat Cell Biol (2013) 0.89
Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. Circ Res (2006) 0.88
Generation of conditional Cited2 null alleles. Genesis (2006) 0.88
NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. Int J Dev Biol (2002) 0.87
Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. Mol Genet Metab (2007) 0.87
Rotary ATPases: models, machine elements and technical specifications. Bioarchitecture (2013) 0.87
Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cell Mol Life Sci (2013) 0.86
The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol (2006) 0.84
Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses. J Immunol (2003) 0.84
Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart. Am J Med Genet A (2011) 0.83
Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10. Stem Cells Dev (2013) 0.82
Molecular analysis of PRKAG2, LAMP2, and NKX2-5 genes in a cohort of 125 patients with accessory atrioventricular connection. Am J Med Genet A (2009) 0.82
Landmarks and lineages in the developing heart. Circ Res (2009) 0.82
Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2). Genesis (2006) 0.81
Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development. PLoS One (2013) 0.80
Epithelial to mesenchymal transition as a portal to stem cell characters embedded in gene networks. Bioessays (2012) 0.80
Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. Mol Cell Biol (2002) 0.79
Regenerative medicine: Heart redevelopment. Nature (2010) 0.77
Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice. Prog Neuropsychopharmacol Biol Psychiatry (2008) 0.77
Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death. Transplantation (2016) 0.76
Investigation of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4. PLoS One (2011) 0.75
Selective inhibition of human group IIA-secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. J Biol Chem (2013) 0.75
Biased DNA segregation and cardiac stem cell therapies. Circ Res (2012) 0.75
Time to mend a broken heart. Stem Cell Res (2007) 0.75
Progress and challenges in the genetics of congenital heart disease. Med J Aust (2005) 0.75
A critical time for stem cell research in Australia. Cell Stem Cell (2008) 0.75
The ontogeny of cardiac regeneration. Circ Res (2011) 0.75
The creation of an historical meteorological database for environmental dose assessment. Environ Monit Assess (2003) 0.75