Published in Circ Res on September 10, 2009
FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res (2011) 1.52
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell (2010) 1.49
22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development. Pediatr Cardiol (2010) 1.44
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32
A matter of life and death: self-renewal in stem cells. EMBO Rep (2012) 1.30
CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis. Am J Respir Cell Mol Biol (2011) 1.05
A new heart for a new head in vertebrate cardiopharyngeal evolution. Nature (2015) 1.04
Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate. Development (2010) 1.02
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet (2012) 1.02
Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome. Curr Allergy Asthma Rep (2013) 0.98
Molecular regulation of cardiomyocyte differentiation. Circ Res (2015) 0.98
The T-box gene family: emerging roles in development, stem cells and cancer. Development (2014) 0.96
NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field. PLoS Biol (2013) 0.92
Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet (2011) 0.91
Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol (2012) 0.88
Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One (2012) 0.87
Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol (2010) 0.86
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. Proc Natl Acad Sci U S A (2014) 0.84
Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development. PLoS Genet (2014) 0.84
Tbx1 is required for second heart field proliferation in zebrafish. Dev Dyn (2013) 0.84
TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome. Hum Mol Genet (2015) 0.84
AIP1 mediates vascular endothelial cell growth factor receptor-3-dependent angiogenic and lymphangiogenic responses. Arterioscler Thromb Vasc Biol (2014) 0.84
DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation. PLoS One (2013) 0.83
Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome. Hum Mol Genet (2014) 0.83
Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. Biomed Res Int (2014) 0.83
Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene. Mamm Genome (2010) 0.82
AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol (2014) 0.81
Heart fields and cardiac morphogenesis. Cold Spring Harb Perspect Med (2014) 0.81
A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice. Mol Carcinog (2011) 0.79
Novel TBX1 loss-of-function mutation causes isolated conotruncal heart defects in Chinese patients without 22q11.2 deletion. BMC Med Genet (2014) 0.79
Tbx1 modulates endodermal and mesodermal differentiation from mouse induced pluripotent stem cells. Stem Cells Dev (2014) 0.79
Jun is required in Isl1-expressing progenitor cells for cardiovascular development. PLoS One (2013) 0.79
Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling. Dev Dyn (2012) 0.78
Rebalancing gene haploinsufficiency in vivo by targeting chromatin. Nat Commun (2016) 0.77
Altered Tbx1 gene expression is associated with abnormal oesophageal development in the adriamycin mouse model of oesophageal atresia/tracheo-oesophageal fistula. Pediatr Surg Int (2014) 0.76
TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells. PLoS One (2015) 0.75
Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. PLoS Genet (2017) 0.75
A 3 base pair deletion in TBX1 leads to reduced protein expression and transcriptional activity. Sci Rep (2017) 0.75
Epithelial tension in the second heart field promotes mouse heart tube elongation. Nat Commun (2017) 0.75
Ciona as a Simple Chordate Model for Heart Development and Regeneration. J Cardiovasc Dev Dis (2016) 0.75
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature (2008) 10.27
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell (2003) 8.00
Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol (1998) 7.27
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell (2006) 6.19
Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet (2005) 5.51
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell (2001) 4.27
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Conotruncal myocardium arises from a secondary heart field. Development (2001) 3.64
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol (2005) 3.58
T-box genes in vertebrate development. Annu Rev Genet (2005) 3.00
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81
The outflow tract of the heart is recruited from a novel heart-forming field. Dev Biol (2001) 2.65
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev (1993) 2.48
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (2006) 2.41
Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol (1996) 2.32
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development (2003) 2.09
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development (2006) 1.82
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (2004) 1.75
T-box transcription factors and their roles in regulatory hierarchies in the developing heart. Development (2005) 1.70
Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res (2006) 1.70
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development (2005) 1.46
Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol (2004) 1.46
Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. Dev Biol (2006) 1.42
Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol (2008) 1.39
Dissecting contiguous gene defects: TBX1. Curr Opin Genet Dev (2005) 1.30
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis (2007) 1.24
Coactivator control of cardiovascular growth and remodeling. Curr Opin Cell Biol (2006) 1.02
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis (2009) 0.97
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development (2006) 1.82
In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet (2007) 1.59
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development (2005) 1.57
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development (2005) 1.46
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development (2006) 1.31
TBX1 is required for inner ear morphogenesis. Hum Mol Genet (2003) 1.30
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet (2006) 1.27
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis (2007) 1.24
Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol (2006) 1.10
Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol (2005) 1.10
Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol (2006) 1.07
Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis (2005) 1.06
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta. Circ Res (2007) 1.02
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet (2012) 1.02
Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm. Dev Dyn (2007) 0.97
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis (2009) 0.97
Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol (2010) 0.94
Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol (2009) 0.94
Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet (2005) 0.94
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome (2010) 0.91
Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol (2010) 0.90
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. J Proteome Res (2009) 0.89
Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome. Semin Cell Dev Biol (2006) 0.88
A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein. PLoS One (2011) 0.87
Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol (2010) 0.86
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol (2007) 0.84
14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol (2012) 0.83
Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene. Mamm Genome (2010) 0.82
A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics (2006) 0.81
Generating and modifying DiGeorge syndrome-like phenotypes in model organisms: is there a common genetic pathway? Trends Genet (2003) 0.81
Tbx1 regulates brain vascularization. Hum Mol Genet (2013) 0.80
Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev Dyn (2003) 0.78
Fate map of serotonin transporter-expressing cells in developing mouse heart. Genesis (2007) 0.78
Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol (2013) 0.76