Published in Toxicol Appl Pharmacol on November 08, 2005
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int (2011) 1.92
Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev (2006) 1.36
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21
Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock. J Assoc Res Otolaryngol (2008) 1.08
Mechanism of protection by metallothionein against acetaminophen hepatotoxicity. Toxicol Appl Pharmacol (2009) 1.00
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. Dig Dis (2015) 0.95
Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). BMC Genomics (2010) 0.86
Changes in hepatic gene expression in response to hepatoprotective levels of zinc. Liver Int (2009) 0.85
Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress. Food Chem Toxicol (2013) 0.85
Remote ischemic preconditioning as treatment for non-ischemic gastrointestinal disorders: beyond ischemia-reperfusion injury. World J Gastroenterol (2014) 0.84
Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70. J Clin Biochem Nutr (2009) 0.82
Protein targets of thioacetamide metabolites in rat hepatocytes. Chem Res Toxicol (2013) 0.77
Simulated diving after heat stress potentiates the induction of heat shock protein 70 and elevates glutathione in human endothelial cells. Cell Stress Chaperones (2009) 0.75
Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics (2015) 0.75
Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice. PLoS One (2017) 0.75
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect (2010) 3.84
The toxicity data landscape for environmental chemicals. Environ Health Perspect (2008) 2.68
Spermatozoal RNA profiles of normal fertile men. Lancet (2002) 2.46
Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility. Fertil Steril (2005) 2.16
Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect (2010) 2.06
Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci (2006) 2.05
Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol (2004) 2.05
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. Toxicol Sci (2011) 2.03
Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs. Hum Mol Genet (2007) 1.62
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect (2011) 1.57
Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential. Environ Health Perspect (2011) 1.57
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environ Sci Technol (2010) 1.54
Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database. Environ Health Perspect (2008) 1.51
Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment. Chem Res Toxicol (2011) 1.38
Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database. Toxicol Sci (2009) 1.38
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. Toxicology (2011) 1.36
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol (2010) 1.32
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol Sci (2010) 1.30
Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB. Reprod Toxicol (2009) 1.22
Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood. Clin Chem (2007) 1.17
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci (2011) 1.16
Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Environ Health Perspect (2012) 1.16
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol (2013) 1.13
Predictive model of rat reproductive toxicity from ToxCast high throughput screening. Biol Reprod (2011) 1.07
Prevention of chemotherapy-induced alopecia in rodent models. Cell Stress Chaperones (2008) 1.06
Environmental impact on vascular development predicted by high-throughput screening. Environ Health Perspect (2011) 1.05
Gene expression patterns associated with infertility in humans and rodent models. Mutat Res (2004) 1.04
Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy. Circulation (2006) 1.04
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells. Toxicol Appl Pharmacol (2004) 1.02
Body weight distributions for risk assessment. Risk Anal (2007) 1.01
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals. J Toxicol Environ Health B Crit Rev (2010) 1.00
In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis. Toxicol Sci (2012) 1.00
Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses. Environ Sci Technol (2014) 0.99
Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity. Toxicol Sci (2007) 0.98
Novel gene switches for targeted and timed expression of proteins of interest. Mol Ther (2005) 0.97
A database for tracking toxicogenomic samples and procedures. Reprod Toxicol (2005) 0.96
HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts. Am J Physiol Heart Circ Physiol (2003) 0.96
Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems. J Biomol Screen (2009) 0.96
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res (2003) 0.96
Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice. Chem Res Toxicol (2006) 0.95
Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice. Environ Health Perspect (2005) 0.93
Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS One (2011) 0.90
Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat. Toxicol Sci (2006) 0.90
Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity. Toxicol Sci (2012) 0.86
Nanoparticle characterization for cancer nanotechnology and other biological applications. Methods Mol Biol (2010) 0.85
Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett (2002) 0.84
DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues. Toxicol Sci (2002) 0.84
Gene expression in head hair follicles plucked from men and women. Ann Clin Lab Sci (2006) 0.84
Advancing the next generation of health risk assessment. Environ Health Perspect (2012) 0.84
Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice. Toxicol Sci (2007) 0.84
Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. Toxicol Sci (2009) 0.83
Measurement of nanomaterials in foods: integrative consideration of challenges and future prospects. ACS Nano (2014) 0.83
Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice. Toxicology (2005) 0.82
Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver. Toxicol Lett (2005) 0.82
Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Toxicol Appl Pharmacol (2006) 0.81
Cocaine-protein targets in mouse liver. Biochem Pharmacol (2003) 0.81
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure. Environ Health Perspect (2015) 0.80
Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Toxicol Appl Pharmacol (2006) 0.80
Influence of Suwannee River humic acid on particle properties and toxicity of silver nanoparticles. Chemosphere (2012) 0.80
Effect of conazole fungicides on reproductive development in the female rat. Reprod Toxicol (2006) 0.80
Inhibition of rat and human steroidogenesis by triazole antifungals. Syst Biol Reprod Med (2009) 0.80
Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells. Chem Res Toxicol (2013) 0.79
Using nuclear receptor activity to stratify hepatocarcinogens. PLoS One (2011) 0.79
Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice. Toxicol Lett (2006) 0.78
Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol (2009) 0.78
Raman spectroscopy-based metabolomics for differentiating exposures to triazole fungicides using rat urine. Anal Chem (2007) 0.77
Derived Reference Doses (RfDs) for the environmental degradates of the herbicides alachlor and acetochlor: results of an independent expert panel deliberation. Regul Toxicol Pharmacol (2010) 0.77
Reproductive and genomic effects in testes from mice exposed to the water disinfectant byproduct bromochloroacetic acid. Reprod Toxicol (2005) 0.77
Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice. Birth Defects Res A Clin Mol Teratol (2009) 0.77
The delivery of a health promotion intervention by a public health promotion specialist improves patient satisfaction in the emergency department. Acad Emerg Med (2012) 0.76
Heat shock proteins and acquired resistance to uranium nephrotoxicity. Toxicology (2005) 0.76
A bioinformatic strategy to rapidly characterize cDNA libraries. Bioinformatics (2002) 0.76
Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice. Toxicol Lett (2008) 0.76
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice. Int Immunopharmacol (2007) 0.76
Manipulating heat shock protein expression in laboratory animals. Methods (2004) 0.76
Derivation of a chronic reference concentration for decalin. Regul Toxicol Pharmacol (2013) 0.75
Differential interferences with clinical chemistry assays by gold nanorods, and gold and silica nanospheres. Nanotoxicology (2014) 0.75
Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program. Syst Biol Reprod Med (2012) 0.75