Published in Am J Ther on November 10, 2005
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal (2010) 1.94
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22
Endoplasmic reticulum stress and diabetic retinopathy. Vasc Health Risk Manag (2008) 1.21
Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia (2012) 0.99
Mitochondrial thiols in the regulation of cell death pathways. Antioxid Redox Signal (2012) 0.97
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS One (2010) 0.97
Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta (2011) 0.96
Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PLoS One (2013) 0.92
Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets. J Endocrinol (2011) 0.90
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol (2010) 0.86
The possible role of epigenetics in gestational diabetes: cause, consequence, or both. Obstet Gynecol Int (2010) 0.84
Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.83
Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. J Diabetes (2012) 0.79
The effect of smoking cessation pharmacotherapies on pancreatic beta cell function. Toxicol Appl Pharmacol (2012) 0.77
Circadian control of β-cell function and stress responses. Diabetes Obes Metab (2015) 0.76
Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice. Diabetes Metab Syndr Obes (2010) 0.75
Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci (2015) 0.75
Mercuric compounds induce pancreatic islets dysfunction and apoptosis in vivo. Int J Mol Sci (2012) 0.75
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem (2004) 3.94
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes (2005) 3.00
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med (2004) 2.82
Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem (2004) 1.99
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem (2005) 1.87
Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study. Diabetes Care (2005) 1.85
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev (2006) 1.76
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. Cell Rep (2013) 1.75
Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine (2012) 1.74
PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes (2005) 1.68
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest (2010) 1.61
Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm (2010) 1.49
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes (2003) 1.46
Is central obesity a good predictor of carotid atherosclerosis in Japanese type 2 diabetes with metabolic syndrome? Endocr J (2007) 1.46
Post-prandial hyperglycemia is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients. Biochem Biophys Res Commun (2005) 1.45
Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid Redox Signal (2007) 1.42
Glycated albumin is a better indicator for glucose excursion than glycated hemoglobin in type 1 and type 2 diabetes. Endocr J (2008) 1.39
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes (2002) 1.39
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J Mol Med (Berl) (2005) 1.38
MafA regulates expression of genes important to islet beta-cell function. Mol Endocrinol (2007) 1.35
Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications. Diabetes Care (2005) 1.34
A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem (2005) 1.32
Elevated C-reactive protein associates with early-stage carotid atherosclerosis in young subjects with type 1 diabetes. Diabetes Care (2002) 1.32
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A (2011) 1.28
Serum level of triglycerides is a potent risk factor comparable to LDL cholesterol for coronary heart disease in Japanese patients with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study (JDCS). J Clin Endocrinol Metab (2011) 1.26
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes (2010) 1.23
Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients. Biochem Biophys Res Commun (2005) 1.21
Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition (2008) 1.21
PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function. Endocr J (2007) 1.20
Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine (2012) 1.20
Postprandial hyperglycemia is a better predictor of the progression of diabetic retinopathy than HbA1c in Japanese type 2 diabetic patients. Diabetes Care (2005) 1.17
Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med (2007) 1.17
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol (2005) 1.15
Soluble factors secreted by T cells promote β-cell proliferation. Diabetes (2013) 1.14
Mental and physical fatigue-related biochemical alterations. Nutrition (2008) 1.14
Role of pim-1 in smooth muscle cell proliferation. J Biol Chem (2004) 1.13
Oxidative stress and the JNK pathway in diabetes. Curr Diabetes Rev (2005) 1.13
Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes. Atherosclerosis (2008) 1.11
Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. Diabetes Res Clin Pract (2002) 1.08
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun (2004) 1.07
Effects of probiotics on allergic rhinitis induced by Japanese cedar pollen: randomized double-blind, placebo-controlled clinical trial. Int Arch Allergy Immunol (2006) 1.07
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem (2003) 1.07
Effect of bread containing resistant starch on postprandial blood glucose levels in humans. Biosci Biotechnol Biochem (2005) 1.06
A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. Diabetes Res Clin Pract (2006) 1.06
Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression. J Biol Chem (2010) 1.06
PDX-1 functions as a master factor in the pancreas. Front Biosci (2008) 1.05
Beta-cell regeneration in a patient with type 1 diabetes mellitus who was receiving immunosuppressive therapy. Ann Intern Med (2003) 1.03
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med (2013) 1.02
Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice. Biochem Biophys Res Commun (2010) 1.02
Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients. Diab Vasc Dis Res (2008) 1.02
Involvement of oxidative stress and the JNK pathway in glucose toxicity. Rev Diabet Stud (2005) 1.01
Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients. Cardiovasc Diabetol (2014) 0.99
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice. Biochem Biophys Res Commun (2007) 0.98
Efficacy of occasional self-monitoring of postprandial blood glucose levels in type 2 diabetic patients without insulin therapy. Diabetes Res Clin Pract (2010) 0.98
Recent advances of intervention to inhibit progression of carotid intima-media thickness in patients with type 2 diabetes mellitus. Stroke (2006) 0.98
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol (2006) 0.98
PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes (2002) 0.97
Components of metabolic syndrome and their combinations as predictors of cardiovascular disease in Japanese patients with type 2 diabetes. Implications for improved definition. Analysis from Japan Diabetes Complications Study (JDCS). J Atheroscler Thromb (2009) 0.96
Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes. Drug News Perspect (2004) 0.96
Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice. Endocr J (2009) 0.96