Published in J Biol Chem on February 09, 2010
Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiol (Oxf) (2011) 1.43
Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest (2013) 1.27
A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell Metab (2012) 1.24
Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells. Diabetes (2010) 1.15
Human β-cell proliferation and intracellular signaling: part 3. Diabetes (2015) 1.00
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass. Exp Diabetes Res (2011) 0.91
Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonists. Cardiovasc Diabetol (2014) 0.88
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. Br J Pharmacol (2014) 0.88
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes (2014) 0.86
EuroDia: a beta-cell gene expression resource. Database (Oxford) (2010) 0.84
Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function. J Biol Chem (2014) 0.82
Clic4, a novel protein that sensitizes β-cells to apoptosis. Mol Metab (2015) 0.80
Incretin-based therapies in prediabetes: Current evidence and future perspectives. World J Diabetes (2014) 0.78
New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochim Biophys Acta (2014) 0.78
Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression. PLoS One (2014) 0.75
Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist. Int J Mol Sci (2017) 0.75
Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling. Int J Endocrinol (2012) 0.75
Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells. PLoS One (2017) 0.75
GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice. Diabetologia (2017) 0.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
The biology of incretin hormones. Cell Metab (2006) 8.92
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med (2001) 4.07
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest (2001) 3.29
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet (2002) 3.12
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci U S A (1992) 3.11
cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol (2000) 2.83
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem (2001) 2.14
Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation (1987) 2.14
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest (2004) 2.11
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells. Nature (2006) 1.98
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest (2002) 1.93
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J Biol Chem (2002) 1.85
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology (2000) 1.81
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia (1999) 1.71
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells. J Physiol (2001) 1.70
Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem (2005) 1.51
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab (2004) 1.49
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. Diabetes (2006) 1.45
Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology (1985) 1.41
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. J Biol Chem (2003) 1.33
GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev (2003) 1.33
New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord (2005) 1.29
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop. Diabetes (2009) 1.20
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes (2007) 1.20
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis. EMBO J (2006) 1.16
Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis. Nat Genet (1995) 1.14
Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell. Endocrinology (1985) 1.12
Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J (2001) 1.05
The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis. FEBS Lett (2000) 1.00
Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines. Mol Pharmacol (1994) 0.96
Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones. Cell Tissue Res (1993) 0.90
Ultrastructural localization of insulin-like growth factor-2 (IGF-2) to the secretory granules of insulin cells: a study in normal and diabetic (GK) rats. Ultrastruct Pathol (1997) 0.90
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature (2008) 6.82
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science (2003) 5.25
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem (2004) 3.94
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell (2005) 3.52
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes (2005) 2.88
Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab (2009) 2.83
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med (2004) 2.82
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. Cell Metab (2008) 2.60
The SLC2 family of facilitated hexose and polyol transporters. Pflugers Arch (2003) 2.58
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A (2007) 2.48
Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am J Physiol Endocrinol Metab (2002) 2.33
Uric acid transport and disease. J Clin Invest (2010) 2.33
International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev (2003) 2.25
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet (2006) 2.21
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest (2004) 2.11
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol (2006) 2.09
Insulin resistance alters islet morphology in nondiabetic humans. Diabetes (2013) 2.01
Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem (2004) 1.99
Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest (2007) 1.99
The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med (2013) 1.97
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res (2008) 1.91
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest (2003) 1.83
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. Cell Rep (2013) 1.75
Brain glucose sensing, counterregulation, and energy homeostasis. Physiology (Bethesda) (2007) 1.74
Serum vitamin D levels are decreased in patients without remission of Graves' disease. Endocrine (2012) 1.74
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest (2010) 1.70
Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology (2004) 1.69
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab (2003) 1.68
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol (2009) 1.66
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest (2010) 1.61
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol (2003) 1.60
Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest (2005) 1.56
Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes (2008) 1.55
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev (2002) 1.52
Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A (2011) 1.50
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab (2005) 1.48
GLUT2 is a high affinity glucosamine transporter. FEBS Lett (2002) 1.47
Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid Redox Signal (2007) 1.42
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38
Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes. J Mol Med (Berl) (2005) 1.38
Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension. Diabetes (2004) 1.38
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. Swiss Med Wkly (2003) 1.38
Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes (2014) 1.37
MafA regulates expression of genes important to islet beta-cell function. Mol Endocrinol (2007) 1.35
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) (2002) 1.32
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A (2011) 1.28
Wnt signaling: relevance to beta-cell biology and diabetes. Trends Endocrinol Metab (2008) 1.28
Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes (2008) 1.27
Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest (2013) 1.27
Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes (2006) 1.27
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes (2011) 1.26
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes (2011) 1.26
RNA-binding protein HuD controls insulin translation. Mol Cell (2012) 1.25
Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A (2010) 1.25
Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes (2008) 1.25
High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J (2009) 1.25
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol (2007) 1.24
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci U S A (2009) 1.23
Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res (2008) 1.23
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes (2010) 1.23
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol (2006) 1.21
PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function. Endocr J (2007) 1.20
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop. Diabetes (2009) 1.20
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes (2007) 1.20
Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine (2012) 1.20
Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med (2007) 1.17
Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A (2009) 1.17
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17
Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes (2008) 1.16
Mouse GLUT9: evidences for a urate uniporter. Am J Physiol Renal Physiol (2009) 1.15
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol (2005) 1.15
Soluble factors secreted by T cells promote β-cell proliferation. Diabetes (2013) 1.14
Role of pim-1 in smooth muscle cell proliferation. J Biol Chem (2004) 1.13
Oxidative stress and the JNK pathway in diabetes. Curr Diabetes Rev (2005) 1.13
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature (2009) 1.10
Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes (2003) 1.10
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem (2003) 1.09
Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes. J Biol Chem (2004) 1.08
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology (2006) 1.08
Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes (2008) 1.08
Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. Diabetes Res Clin Pract (2002) 1.08
Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus. PLoS One (2011) 1.07
Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem (2013) 1.06
Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J (2010) 1.05
Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight. Cell Metab (2011) 1.05
PDX-1 functions as a master factor in the pancreas. Front Biosci (2008) 1.05
Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. J Biol Chem (2004) 1.05
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metab (2010) 1.05
Near-infrared fluorescent probe for imaging of pancreatic beta cells. Bioconjug Chem (2010) 1.04