Published in Mol Cancer Res on November 01, 2005
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell (2012) 1.40
DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions. Proc Natl Acad Sci U S A (2013) 1.37
FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res (2009) 1.33
Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem (2009) 1.21
Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation. Mol Cancer (2010) 1.16
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet (2010) 1.13
IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol (2012) 1.10
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A (2010) 1.09
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res (2012) 0.99
Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging (Albany NY) (2014) 0.99
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Sci Rep (2013) 0.99
Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism. J Biol Chem (2011) 0.96
Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J Biol Chem (2012) 0.94
Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.91
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol (2012) 0.89
ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence. BMC Cancer (2011) 0.86
Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11. Mol Biol Cell (2008) 0.84
Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. BMC Cancer (2015) 0.83
Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy. Antioxid Redox Signal (2014) 0.82
Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma. Cancer Cell Int (2014) 0.82
The role of p21 in regulating mammalian regeneration. Stem Cell Res Ther (2011) 0.81
A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines. PLoS One (2014) 0.80
The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells. PLoS One (2014) 0.79
Identification of a small molecule 1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53. Acta Pharmacol Sin (2013) 0.79
Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS One (2014) 0.78
Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation. PLoS One (2014) 0.78
p38δ regulates p53 to control p21Cip1 expression in human epidermal keratinocytes. J Biol Chem (2014) 0.77
Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis. Front Pharmacol (2016) 0.76
Investigating cytokinesis failure as a strategy in cancer therapy. Oncotarget (2016) 0.76
The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells. Oncotarget (2015) 0.75
Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci (2015) 0.75
Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3. Int J Mol Sci (2012) 0.75
Senescence Process in Primary Wilms' Tumor Cell Culture Induced by p53 Independent p21 Expression. J Cancer (2016) 0.75
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence. Biol Res (2016) 0.75
CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid. Oncol Lett (2017) 0.75
DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53. Mutat Res (2013) 0.75
Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21(waf-1). Age (Dordr) (2016) 0.75
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med (2012) 6.93
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A (2002) 3.11
Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat Chem Biol (2007) 2.83
I/NI-calls for the exclusion of non-informative genes: a highly effective filtering tool for microarray data. Bioinformatics (2007) 2.34
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J Biol Chem (2008) 2.07
Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol (2005) 2.00
A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol (2012) 1.79
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. Mol Biol Cell (2005) 1.68
Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain. J Neurosci (2006) 1.54
Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol Ther (2004) 1.40
In situ detection of starvation-induced autophagy. J Histochem Cytochem (2005) 1.38
Design and analysis of drug combination experiments. Biom J (2005) 1.23
Housekeeping genes as internal standards in cancer research. Mol Diagn (2004) 1.23
Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations. Autophagy (2006) 1.18
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc Natl Acad Sci U S A (2002) 1.18
Transcriptional regulation of two stage-specifically expressed genes in the protozoan parasite Toxoplasma gondii. Nucleic Acids Res (2005) 1.16
Obestatin does not activate orphan G protein-coupled receptor GPR39. Biochem Biophys Res Commun (2006) 1.15
Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs. BMC Genomics (2013) 1.12
Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology (2006) 1.12
JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res (2009) 1.09
Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cereb Cortex (2009) 1.01
Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther (2003) 1.01
IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity. Neuropsychopharmacology (2007) 0.96
Insights on biology and pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-catenin, and NF-κB pathways in osteoarthritis. Curr Pharm Des (2012) 0.96
Peptidomics coming of age: a review of contributions from a bioinformatics angle. J Proteome Res (2010) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
Thymosin beta 4 mRNA and peptide expression in phagocytic cells of different mouse tissues. Peptides (2009) 0.92
Alteration of frizzled expression in renal cell carcinoma. Tumour Biol (2004) 0.90
Structural and functional characterization of the TgDRE multidomain protein, a DNA repair enzyme from Toxoplasma gondii. Biochemistry (2006) 0.90
Rapid microarray processing using a disposable hybridization chamber with an integrated micropump. Lab Chip (2012) 0.90
Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts. Cancer Lett (2011) 0.88
Spectral clustering in peptidomics studies helps to unravel modification profile of biologically active peptides and enhances peptide identification rate. Proteomics (2009) 0.87
Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans. FEBS Lett (2004) 0.86
The ontogeny of drug metabolizing enzymes and transporters in the rat. Reprod Toxicol (2008) 0.86
Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library. Chem Biol (2003) 0.85
Transcriptional response to corticotropin-releasing factor in AtT-20 cells. Mol Pharmacol (2004) 0.85
Flow cytometric evaluation of a model for phagocytosis of cells undergoing apoptosis. J Immunol Methods (2004) 0.85
Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program. Pediatr Blood Cancer (2011) 0.84
Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice. Gastroenterology (2007) 0.84
EUROPLUS ANCA BIOCHIP mosaic: PR3 and MPO antigen microdots improve the laboratory diagnostics of ANCA-associated vasculitis. J Immunol Methods (2009) 0.84
The SAG5 locus of Toxoplasma gondii encodes three novel proteins belonging to the SAG1 family of surface antigens. Int J Parasitol (2002) 0.83
AMIGO2 mRNA expression in hippocampal CA2 and CA3a. Brain Struct Funct (2013) 0.82
The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function. EMBO Rep (2003) 0.82
Central administration of obestatin fails to show inhibitory effects on food and water intake in mice. Regul Pept (2009) 0.82
Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors. Mol Cancer Ther (2006) 0.81
Antifungal activity in plants from Chinese traditional and folk medicine. J Ethnopharmacol (2012) 0.80
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. Bioorg Med Chem Lett (2009) 0.80
Microarray profiling of DNA extracted from FFPE tissues using SNP 6.0 Affymetrix platform. Methods Mol Biol (2011) 0.80
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chem Neurosci (2013) 0.79
Improving the identification rate of endogenous peptides using electron transfer dissociation and collision-induced dissociation. J Proteome Res (2013) 0.79
Design and Selection of Antisense Oligonucleotides Targeting Transforming Growth Factor Beta (TGF-β) Isoform mRNAs for the Treatment of Solid Tumors. Methods Mol Biol (2015) 0.79
A hybrid, de novo based, genome-wide database search approach applied to the sea urchin neuropeptidome. J Proteome Res (2010) 0.79
Comparison of extraction methods for peptidomics analysis of mouse brain tissue. J Neurosci Methods (2011) 0.78
Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors. Eur J Med Chem (2005) 0.78
Evaluation of the antibacterial and antibiofilm activities of novel CRAMP-vancomycin conjugates with diverse linkers. Org Biomol Chem (2015) 0.78
Modified poly(propylene imine) dendrimers as effective transfection agents for catalytic DNA enzymes (DNAzymes). J Drug Target (2006) 0.77
The hepatocarcinoma cell line HepG2 does not express a GHS-R1a-type ghrelin receptor. J Recept Signal Transduct Res (2007) 0.77
Peptidomic analysis of human reflex tear fluid. Peptides (2012) 0.77
PIUS: peptide identification by unbiased search. Bioinformatics (2013) 0.76
Discovering H-bonding rules in crystals with inductive logic programming. Mol Pharm (2006) 0.76
R176502, a new bafilolide metabolite with potent antiproliferative activity from a novel Micromonospora species. J Antibiot (Tokyo) (2003) 0.76
Mapping of carboxypeptidase m in normal human kidney and renal cell carcinoma: expression in tumor-associated neovasculature and macrophages. J Histochem Cytochem (2012) 0.75
Cellular interacting proteins of functional screen-derived antiproliferative and cytotoxic peptides discovered using shotgun peptide sequencing. Chem Biol (2003) 0.75
The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord. Eur J Pharmacol (2010) 0.75
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors. Bioorg Med Chem Lett (2003) 0.75