Published in J Biol Chem on December 01, 2005
Low CSF levels of both α-synuclein and the α-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS One (2013) 1.10
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). Biochimie (2010) 0.97
Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines. J Neurochem (2008) 0.96
Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem (2010) 0.95
Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. Glia (2013) 0.90
Functional role of kallikrein 6 in regulating immune cell survival. PLoS One (2011) 0.89
The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease. Curr Top Microbiol Immunol (2008) 0.89
The autolytic regulation of human kallikrein-related peptidase 6. Biochemistry (2007) 0.88
Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol (2011) 0.87
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biol Chem (2012) 0.87
Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis. Brain Pathol (2012) 0.85
Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma. Neuro Oncol (2013) 0.84
Kallikreins - The melting pot of activity and function. Biochimie (2015) 0.82
Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model. PLoS One (2011) 0.81
Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration. J Neuropathol Exp Neurol (2013) 0.81
Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis. Protein Sci (2008) 0.81
Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. Antimicrob Agents Chemother (2015) 0.81
Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis. Biol Chem (2010) 0.80
Substrate specificity of human kallikreins 1 and 6 determined by phage display. Protein Sci (2008) 0.80
Plasmatic level of neurosin predicts outcome of mild cognitive impairment. Int Arch Med (2008) 0.79
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer. BMC Cancer (2016) 0.78
Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response. Biol Chem (2014) 0.77
Plasma Kallikrein enhances platelet aggregation response by subthreshold doses of ADP. Biochimie (2017) 0.75
A multifunctional serine protease primes the malaria parasite for red blood cell invasion. EMBO J (2009) 1.67
Proteinase-activated receptors, targets for kallikrein signaling. J Biol Chem (2006) 1.63
Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development. J Biol Chem (2003) 1.35
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage. Diagn Microbiol Infect Dis (2013) 1.30
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy (2009) 1.26
Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. J Biol Chem (2002) 1.21
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem (2008) 1.20
Activation profiles and regulatory cascades of the human kallikrein-related peptidases. J Biol Chem (2007) 1.19
Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. Nat Protoc (2008) 1.18
Membrane fusion induced by vesicular stomatitis virus depends on histidine protonation. J Biol Chem (2003) 1.17
Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing. FEBS Lett (2007) 1.16
ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. J Biol Chem (2004) 1.15
Experimental support for the foldability-function tradeoff hypothesis: segregation of the folding nucleus and functional regions in fibroblast growth factor-1. Protein Sci (2012) 1.13
Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc Natl Acad Sci U S A (2010) 1.13
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem (2006) 1.12
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein. Biochem J (2003) 1.12
Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. J Biol Chem (2002) 1.12
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biol Chem (2006) 1.07
Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biol Chem (2008) 1.06
Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species. J Biol Chem (2005) 1.05
A glimpse on biological activities of tellurium compounds. An Acad Bras Cienc (2009) 1.03
Enzymatic properties of rat myelencephalon-specific protease. Biochemistry (2002) 1.03
Detection of SPM-1-producing Pseudomonas aeruginosa and class D β-lactamase-producing Acinetobacter baumannii isolates by use of liquid chromatography-mass spectrometry and matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol (2012) 1.03
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. J Mol Biol (2009) 1.03
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases. J Biol Chem (2009) 1.01
Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease. FASEB J (2004) 1.01
Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions. J Mol Biol (2007) 1.00
Metagenomic analysis of a tropical composting operation at the são paulo zoo park reveals diversity of biomass degradation functions and organisms. PLoS One (2013) 0.99
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. J Biol Chem (2011) 0.99
Design and use of highly specific substrates of neutrophil elastase and proteinase 3. Am J Respir Cell Mol Biol (2003) 0.99
A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay. Nat Protoc (2006) 0.99
Cathepsin X binds to cell surface heparan sulfate proteoglycans. Arch Biochem Biophys (2005) 0.99
T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun (2005) 0.99
Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium. Mol Biochem Parasitol (2005) 0.98
A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J Mol Biol (2008) 0.98
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. J Biol Chem (2005) 0.97
Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain. J Biol Chem (2001) 0.96
Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines. J Neurochem (2008) 0.96
A polypeptide "building block" for the β-trefoil fold identified by "top-down symmetric deconstruction". J Mol Biol (2011) 0.95
Amylolytic microorganism from são paulo zoo composting: isolation, identification, and amylase production. Enzyme Res (2011) 0.94
Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis. J Biol Chem (2006) 0.94
Identification of a key structural element for protein folding within beta-hairpin turns. J Mol Biol (2003) 0.94
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal Biochem (2004) 0.93
Neutral endopeptidase expression in mesangial cells. J Renin Angiotensin Aldosterone Syst (2003) 0.93
1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding. Proteins (2005) 0.93
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Arch Biochem Biophys (2009) 0.93
Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury. Br J Pharmacol (2003) 0.92
Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. Eur J Biochem (2002) 0.92
An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Sci (2012) 0.92
Structural biology of the aldo-keto reductase family of enzymes: catalysis and cofactor binding. Cell Biochem Biophys (2003) 0.92
Probing the interaction between vesicular stomatitis virus and phosphatidylserine. Eur Biophys J (2005) 0.91
Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. Glia (2013) 0.90
Identification of the allosteric regulatory site of insulysin. PLoS One (2011) 0.90
Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J Mol Biol (2009) 0.90
Accommodation of a highly symmetric core within a symmetric protein superfold. Protein Sci (2003) 0.90
Protein design at the interface of the pre-biotic and biotic worlds. Arch Biochem Biophys (2012) 0.90
Symmetric primary and tertiary structure mutations within a symmetric superfold: a solution, not a constraint, to achieve a foldable polypeptide. J Mol Biol (2004) 0.89
Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein. Proc Natl Acad Sci U S A (2013) 0.89
Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth. Mol Cancer (2007) 0.89
Functional role of kallikrein 6 in regulating immune cell survival. PLoS One (2011) 0.89
In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides (2007) 0.88
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates. J Biol Chem (2002) 0.88
The autolytic regulation of human kallikrein-related peptidase 6. Biochemistry (2007) 0.88
Identification of bradykinins in solitary wasp venoms. Toxicon (2002) 0.88
Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease. Biochemistry (2009) 0.88
Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. J Neurochem (2013) 0.88
Immune evasion by pathogenic Leptospira strains: the secretion of proteases that directly cleave complement proteins. J Infect Dis (2013) 0.88
Inhibition of neutrophil elastase by alpha1-protease inhibitor at the surface of human polymorphonuclear neutrophils. J Immunol (2005) 0.88
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L. Arch Biochem Biophys (2004) 0.87