Published in Neurosci Lett on December 05, 2005
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect (2011) 3.87
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol (2011) 2.94
Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease. Neurology (2015) 2.88
Diagnosis and treatment of Parkinson disease: molecules to medicine. J Clin Invest (2006) 2.86
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol (2010) 2.73
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol (2009) 2.67
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One (2010) 2.15
100 years of Lewy pathology. Nat Rev Neurol (2012) 2.15
Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Exp Neurol (2007) 1.89
Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol (2013) 1.77
Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. PLoS One (2010) 1.72
Premotor Parkinson's disease: concepts and definitions. Mov Disord (2012) 1.70
Medical records documentation of constipation preceding Parkinson disease: A case-control study. Neurology (2009) 1.64
α-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.62
Innervation of the gastrointestinal tract: patterns of aging. Auton Neurosci (2007) 1.61
Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci (2015) 1.53
Olfaction in Parkinson's disease and related disorders. Neurobiol Dis (2011) 1.51
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A (2014) 1.44
Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder. Neurology (2015) 1.44
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep (2012) 1.36
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet (2010) 1.36
α-Synuclein in cutaneous autonomic nerves. Neurology (2013) 1.32
Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: autonomic pathway implicated in Parkinson's disease? Neuroscience (2008) 1.29
Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure. Arch Neurol (2009) 1.29
Anxious personality predicts an increased risk of Parkinson's disease. Mov Disord (2010) 1.22
Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Clin Auton Res (2007) 1.21
Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis (2011) 1.21
Glutathione metabolism and Parkinson's disease. Free Radic Biol Med (2013) 1.20
Submandibular gland needle biopsy for the diagnosis of Parkinson disease. Neurology (2014) 1.19
Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss. Acta Neuropathol (2012) 1.18
Cutaneous neuropathy in Parkinson's disease: a window into brain pathology. Acta Neuropathol (2014) 1.12
Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord (2012) 1.11
Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease. Exp Neurol (2009) 1.11
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice. Neurotherapeutics (2012) 1.11
The prion hypothesis in Parkinson's disease: Braak to the future. Acta Neuropathol Commun (2013) 1.11
The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease. Mov Disord (2011) 1.10
Gastrointestinal manifestations in Parkinson's disease: prevalence and occurrence before motor symptoms. J Neurol (2012) 1.08
Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases. Parkinsonism Relat Disord (2009) 1.08
Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front Cell Neurosci (2014) 1.07
Interaction between pathogenic proteins in neurodegenerative disorders. J Cell Mol Med (2012) 1.06
Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies? Neurobiol Aging (2009) 1.04
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link? Mol Neurobiol (2012) 1.04
Toxin-induced and genetic animal models of Parkinson's disease. Parkinsons Dis (2010) 1.04
Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease. Arch Neurol (2009) 1.03
Behavioral phenotyping of mouse models of Parkinson's disease. Behav Brain Res (2010) 1.02
Animal models of the non-motor features of Parkinson's disease. Neurobiol Dis (2012) 1.00
Thinking laterally about neurodegenerative proteinopathies. J Clin Invest (2013) 0.99
Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET. Brain (2014) 0.99
Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors. Nat Rev Neurol (2015) 0.98
A prospective study of bowel movement frequency and risk of Parkinson's disease. Am J Epidemiol (2011) 0.98
Altered pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol (2012) 0.97
Bowel movement frequency in late-life and substantia nigra neuron density at death. Mov Disord (2009) 0.97
The role of extracellular vesicles in the progression of neurodegenerative disease and cancer. Trends Mol Med (2014) 0.97
The cybrid model of sporadic Parkinson's disease. Exp Neurol (2009) 0.95
Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat. Exp Neurol (2009) 0.95
Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease. Parkinsons Dis (2011) 0.95
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. J Parkinsons Dis (2015) 0.93
Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection. Ther Adv Endocrinol Metab (2013) 0.92
Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol (2013) 0.92
Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci (2015) 0.92
Parkinson disease affects peripheral sensory nerves in the pharynx. J Neuropathol Exp Neurol (2013) 0.91
Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation. Neurogastroenterol Motil (2012) 0.90
Age-related changes in vagal afferents innervating the gastrointestinal tract. Auton Neurosci (2009) 0.90
The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis. Alzheimers Res Ther (2014) 0.88
α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiol Dis (2012) 0.88
Differential effect of Helicobacter pylori eradication on time-trends in brady/hypokinesia and rigidity in idiopathic parkinsonism. Helicobacter (2010) 0.88
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Sci Signal (2015) 0.87
Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test. J Neurol (2010) 0.87
Gastrointestinal dysfunction in a Parkinson's disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus. J Mol Neurosci (2011) 0.86
Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice. Exp Neurobiol (2011) 0.86
Gastrointestinal Autonomic Dysfunction in Patients with Parkinson's Disease. J Mov Disord (2015) 0.86
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. J Neurochem (2016) 0.85
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease. Acta Neuropathol (2017) 0.85
Brain-gut-microbiota axis in Parkinson's disease. World J Gastroenterol (2015) 0.85
Neuropathobiology of non-motor symptoms in Parkinson disease. J Neural Transm (Vienna) (2015) 0.85
Biopsable neural tissues: toward new biomarkers for Parkinson's disease? Front Psychiatry (2010) 0.85
Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study. Gut Pathog (2012) 0.84
Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation. Exp Neurobiol (2014) 0.84
Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS One (2011) 0.84
Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants. Mol Ther (2015) 0.84
Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study. J Neurol (2014) 0.83
Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp Neurol (2009) 0.83
Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review. CNS Neurosci Ther (2009) 0.83
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons. Acta Neuropathol Commun (2015) 0.82
Parkinson's disease. Subcell Biochem (2012) 0.82
Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease. World J Gastroenterol (2011) 0.82
Peripheral aetiopathogenic drivers and mediators of Parkinson's disease and co-morbidities: role of gastrointestinal microbiota. J Neurovirol (2015) 0.82
Anorectal manometric dysfunctions in newly diagnosed, early-stage Parkinson's disease. J Clin Neurol (2012) 0.82
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein. Mol Brain (2012) 0.82
Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther (2015) 0.82
Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson's disease etiology. Sci Rep (2016) 0.82
Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease. Mov Disord (2013) 0.81
Considerations on the role of environmental toxins in idiopathic Parkinson's disease pathophysiology. Transl Neurodegener (2014) 0.80
Nonmotor symptoms in a malaysian Parkinson's disease population. Parkinsons Dis (2014) 0.80
Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system. J Mol Med (Berl) (2016) 0.80
The frequency and severity of gastrointestinal symptoms in patients with early Parkinson's disease. J Mov Disord (2014) 0.80
Evaluation of gastric emptying in familial and sporadic Parkinson disease. Parkinsonism Relat Disord (2009) 0.80
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cell Mol Neurobiol (2016) 0.80
Parkinson disease. Nonmotor symptoms in Parkinson disease: the PRIAMO study. Nat Rev Neurol (2009) 0.80
Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging (2002) 22.40
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (2006) 8.15
Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res (2004) 7.06
The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol (2010) 5.59
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol (2011) 3.69
Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes. PLoS Biol (2006) 3.06
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol (2009) 2.60
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J Neurol (2002) 2.37
Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. Mov Disord (2006) 2.31
100 years of Lewy pathology. Nat Rev Neurol (2012) 2.15
Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology (2008) 2.13
A timeline for Parkinson's disease. Parkinsonism Relat Disord (2009) 1.75
Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol (2011) 1.70
Cerebral amyloid angiopathy and its relationship to Alzheimer's disease. Acta Neuropathol (2008) 1.60
Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol (2007) 1.56
The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ (2006) 1.55
Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51
Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cell Biol (2009) 1.45
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol (2007) 1.39
Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease. Acta Neuropathol (2001) 1.36
PART is part of Alzheimer disease. Acta Neuropathol (2015) 1.31
Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nat Rev Neurol (2013) 1.29
Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci (2009) 1.27
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. J Alzheimers Dis (2006) 1.25
Early diagnosis of Acanthamoeba infection during routine cytological examination of cerebrospinal fluid. J Clin Microbiol (2006) 1.24
Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta Neuropathol (2004) 1.24
Neurodegeneration in normal brain aging and disease. Sci Aging Knowledge Environ (2004) 1.24
Cognitive decline correlates with neuropathological stage in Parkinson's disease. J Neurol Sci (2006) 1.19
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J Neurosci (2006) 1.19
Where, when, and in what form does sporadic Alzheimer's disease begin? Curr Opin Neurol (2012) 1.18
Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathy. Invest Ophthalmol Vis Sci (2002) 1.17
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol (2013) 1.11
Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Hum Mol Genet (2004) 1.10
Differences in DNA methylation patterns and expression of the CCRK gene in human and nonhuman primate cortices. Mol Biol Evol (2009) 1.07
Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation. Neurobiol Aging (2004) 1.06
Assessing fetal nerve cell grafts in Parkinson's disease. Nat Med (2008) 1.04
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. Am J Pathol (2002) 1.04
Poor and protracted myelination as a contributory factor to neurodegenerative disorders. Neurobiol Aging (2004) 1.04
Staging of sporadic Parkinson disease-related alpha-synuclein pathology: inter- and intra-rater reliability. J Neuropathol Exp Neurol (2005) 1.03
Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process? Acta Neuropathol (2014) 1.01
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol (2010) 1.01
Ontogeny of the human amygdala. Ann N Y Acad Sci (2003) 1.01
Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathol (2010) 0.98
High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging (2004) 0.97
TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathol (2014) 0.96
Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol (2011) 0.93
Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. J Neuropathol Exp Neurol (2010) 0.93
Age-related microvascular degeneration in the human cerebral periventricular white matter. Acta Neuropathol (2006) 0.93
Degeneration of the cerebellum in Huntington's disease (HD): possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process. Brain Pathol (2012) 0.92
Spinocerebellar ataxia type 3 (SCA3): thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions. Brain Pathol (2006) 0.91
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol Aging (2012) 0.90
Biological characterisation of vascular grafts cultured in a bioreactor. Biomaterials (2005) 0.89
Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered. Exp Neurol (2008) 0.89
Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis. Lancet (2003) 0.88
Histological findings in coil-packed experimental aneurysms 3 months after embolization. Neurosurgery (2002) 0.87
Alzheimer's disease: pathogenesis and prevention. Alzheimers Dement (2012) 0.87
A not entirely benign procedure: progression of Parkinson's disease. Acta Neuropathol (2008) 0.87
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3. J Neuropathol Exp Neurol (2003) 0.86
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol (2005) 0.86
Evolutional aspects of Alzheimer's disease pathogenesis. J Alzheimers Dis (2013) 0.85
Reply: the early pathological process in sporadic Alzheimer's disease. Acta Neuropathol (2013) 0.85
Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Am J Clin Pathol (2005) 0.84
Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology. J Neuropathol Exp Neurol (2006) 0.84
Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapy. Brain Res Rev (2006) 0.83
Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol (2009) 0.83
Tissue engineering of blood vessels: characterization of smooth-muscle cells for culturing on collagen-and-elastin-based scaffolds. Biotechnol Appl Biochem (2004) 0.83
Importance of 123I-metaiodobenzylguanidine scintigraphy/single photon emission computed tomography for diagnosis and differential diagnostics of Parkinson syndromes. Neurodegener Dis (2010) 0.82
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm (Vienna) (2010) 0.82
Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: a hypothesis. Acta Neuropathol (2013) 0.82
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system. J Neurosci Methods (2013) 0.80
Familial cortical tremor with epilepsy and cerebellar pathological findings. Mov Disord (2004) 0.80
Brain macrophages and microglia in human fetal hydrocephalus. Brain Dev (2004) 0.78
Pharyngeal selective brain cooling is associated with reduced CNS cortical lesion after experimental traumatic brain injury in rats. J Neurotrauma (2010) 0.78
Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff. J Parkinsons Dis (2017) 0.75
Prions, mad cow disease, and preventive measures: a critical appraisal. Med Microbiol Immunol (2003) 0.75
Anomalous alterations affecting microglia in the central nervous system of a fetus at 12 weeks of gestation: case report. Acta Neuropathol (2003) 0.75
Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathol (2015) 0.75
Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains. J Alzheimers Dis (2004) 0.75
July 2003: 62-year-old female with progressive muscular weakness. Brain Pathol (2004) 0.75