Alzheimer's pathogenesis: is there neuron-to-neuron propagation?

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMID 21516512)

Published in Acta Neuropathol on April 24, 2011

Authors

Heiko Braak1, Kelly Del Tredici

Author Affiliations

1: Clinical Neuroanatomy (Department of Neurology), Center for Clinical Research, University of Ulm, Ulm, Germany. heiko.braak@uni-ulm.de

Articles citing this

Alzheimer mechanisms and therapeutic strategies. Cell (2012) 5.24

Trans-synaptic spread of tau pathology in vivo. PLoS One (2012) 4.53

Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J Neurosci (2013) 2.90

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proc Natl Acad Sci U S A (2012) 2.36

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat Med (2014) 1.85

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem (2012) 1.79

Biology and genetics of prions causing neurodegeneration. Annu Rev Genet (2013) 1.63

Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep (2013) 1.57

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders. Cell Tissue Res (2012) 1.31

Molecular nexopathies: a new paradigm of neurodegenerative disease. Trends Neurosci (2013) 1.29

Mild cognitive impairment: pathology and mechanisms. Acta Neuropathol (2011) 1.20

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS One (2012) 1.19

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease. PLoS One (2011) 1.16

The dendritic hypothesis for Alzheimer's disease pathophysiology. Brain Res Bull (2013) 1.14

GSK3 and Alzheimer's Disease: Facts and Fiction…. Front Mol Neurosci (2011) 1.09

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology. J Biol Chem (2013) 1.07

Circadian clocks and neurodegenerative diseases: time to aggregate? Curr Opin Neurobiol (2013) 1.07

Interaction between pathogenic proteins in neurodegenerative disorders. J Cell Mol Med (2012) 1.06

Intracerebral propagation of Alzheimer's disease: strengthening evidence of a herpes simplex virus etiology. Alzheimers Dement (2012) 1.04

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease. Proc Natl Acad Sci U S A (2013) 0.97

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PLoS One (2015) 0.97

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease. Alzheimers Res Ther (2013) 0.97

Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. Front Neurol (2013) 0.96

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathol (2014) 0.95

Alzheimer's disease: a clinical practice-oriented review. Front Neurol (2012) 0.95

Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem (2014) 0.95

Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A (2013) 0.95

Corruption and spread of pathogenic proteins in neurodegenerative diseases. J Biol Chem (2012) 0.93

Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies. Prion (2012) 0.93

Interaction between α-synuclein and other proteins in neurodegenerative disorders. ScientificWorldJournal (2011) 0.89

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. J Neurochem (2015) 0.88

Shared mechanisms of neurodegeneration in Alzheimer's disease and Parkinson's disease. Biomed Res Int (2014) 0.88

Demyelination in mild cognitive impairment suggests progression path to Alzheimer's disease. PLoS One (2013) 0.88

Brain site-specific proteome changes in aging-related dementia. Exp Mol Med (2013) 0.87

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. J Biol Chem (2014) 0.86

Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging. Age (Dordr) (2012) 0.86

Alzheimer disease: a tale of two prions. Prion (2012) 0.86

Clinico-pathological correlations of the most common neurodegenerative dementias. Front Neurol (2012) 0.86

Characteristics of Tau and Its Ligands in PET Imaging. Biomolecules (2016) 0.85

Can lesions to the motor cortex induce amyotrophic lateral sclerosis? J Neurol (2013) 0.84

The sleep-wake cycle and Alzheimer's disease: what do we know? Neurodegener Dis Manag (2014) 0.84

Single mutations in tau modulate the populations of fibril conformers through seed selection. Angew Chem Int Ed Engl (2014) 0.82

Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: high-resolution fast spin-echo T1-weighted imaging. Geriatr Gerontol Int (2014) 0.81

Norepinephrine Protects against Amyloid-β Toxicity via TrkB. J Alzheimers Dis (2015) 0.80

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease. Brain (2015) 0.80

Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome. Brain Pathol (2015) 0.79

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. Acta Neuropathol Commun (2014) 0.78

Locus Coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease. Neurobiol Stress (2015) 0.77

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology. Front Aging Neurosci (2015) 0.77

Association of APOE with tau-tangle pathology with and without β-amyloid. Neurobiol Aging (2015) 0.77

Central syntropic effects elicited by trigeminal proprioceptive equilibrium in Alzheimer's disease: a case report. J Med Case Rep (2012) 0.77

Transport of cargo from periphery to brain by circulating monocytes. Brain Res (2015) 0.76

Moving away from amyloid Beta to move on in Alzheimer research. Front Aging Neurosci (2015) 0.76

Alzheimer's disease and prion protein. Intractable Rare Dis Res (2013) 0.76

Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem (2016) 0.76

Connectivity Disruption, Atrophy, and Hypometabolism within Posterior Cingulate Networks in Alzheimer's Disease. Front Neurosci (2016) 0.76

Selective vulnerabilities and biomarkers in neurocognitive aging. F1000Res (2017) 0.75

Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine. Neuropharmacology (2015) 0.75

Mouse-based genetic modeling and analysis of Down syndrome. Br Med Bull (2016) 0.75

Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. Neuroimage (2015) 0.75

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation. Redox Biol (2016) 0.75

Connectivity, not region-intrinsic properties, predicts regional vulnerability to progressive tau pathology in mouse models of disease. Acta Neuropathol Commun (2017) 0.75

Articles by these authors

Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging (2002) 22.40

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol (2006) 8.15

Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res (2004) 7.06

The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol (2010) 5.59

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77

Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol (2011) 3.69

Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett (2005) 3.30

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol (2009) 2.60

Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J Neurol (2002) 2.37

Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. Mov Disord (2006) 2.31

100 years of Lewy pathology. Nat Rev Neurol (2012) 2.15

Invited Article: Nervous system pathology in sporadic Parkinson disease. Neurology (2008) 2.13

A timeline for Parkinson's disease. Parkinsonism Relat Disord (2009) 1.75

Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol (2007) 1.56

The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ (2006) 1.55

Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51

Neuroanatomy and pathology of sporadic Parkinson's disease. Adv Anat Embryol Cell Biol (2009) 1.45

Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol (2007) 1.39

PART is part of Alzheimer disease. Acta Neuropathol (2015) 1.31

Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nat Rev Neurol (2013) 1.29

Parkinson's disease: the dual hit theory revisited. Ann N Y Acad Sci (2009) 1.27

Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. J Alzheimers Dis (2006) 1.25

Neurodegeneration in normal brain aging and disease. Sci Aging Knowledge Environ (2004) 1.24

Cognitive decline correlates with neuropathological stage in Parkinson's disease. J Neurol Sci (2006) 1.19

Where, when, and in what form does sporadic Alzheimer's disease begin? Curr Opin Neurol (2012) 1.18

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol (2013) 1.11

Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-beta formation. Neurobiol Aging (2004) 1.06

Assessing fetal nerve cell grafts in Parkinson's disease. Nat Med (2008) 1.04

Poor and protracted myelination as a contributory factor to neurodegenerative disorders. Neurobiol Aging (2004) 1.04

Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. Am J Pathol (2002) 1.04

Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process? Acta Neuropathol (2014) 1.01

Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord. Acta Neuropathol (2010) 1.01

Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathol (2010) 0.98

High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe. Neurobiol Aging (2004) 0.97

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathol (2014) 0.96

Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol (2011) 0.93

Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol Aging (2012) 0.90

Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered. Exp Neurol (2008) 0.89

A not entirely benign procedure: progression of Parkinson's disease. Acta Neuropathol (2008) 0.87

Alzheimer's disease: pathogenesis and prevention. Alzheimers Dement (2012) 0.87

Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol (2005) 0.86

Evolutional aspects of Alzheimer's disease pathogenesis. J Alzheimers Dis (2013) 0.85

Reply: the early pathological process in sporadic Alzheimer's disease. Acta Neuropathol (2013) 0.85

Relationship of apolipoprotein E and age at onset to Parkinson disease neuropathology. J Neuropathol Exp Neurol (2006) 0.84

Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study. Acta Neuropathol (2009) 0.83

Importance of 123I-metaiodobenzylguanidine scintigraphy/single photon emission computed tomography for diagnosis and differential diagnostics of Parkinson syndromes. Neurodegener Dis (2010) 0.82

Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: a hypothesis. Acta Neuropathol (2013) 0.82

Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases. J Neural Transm (Vienna) (2010) 0.82

Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system. J Neurosci Methods (2013) 0.80

Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff. J Parkinsons Dis (2017) 0.75

Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathol (2015) 0.75