Published in Q Rev Biophys on December 09, 2005
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complex. Structure (2008) 3.01
Helical extension of the neuronal SNARE complex into the membrane. Nature (2009) 2.92
Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet (2007) 2.77
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes. PLoS Biol (2006) 2.17
Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. Nat Struct Mol Biol (2010) 2.10
The SNARE motif is essential for the formation of syntaxin clusters in the plasma membrane. Biophys J (2006) 2.04
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain (2008) 1.92
A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity. J Cell Biol (2007) 1.87
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2007) 1.79
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A (2008) 1.68
Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotides. Proc Natl Acad Sci U S A (2009) 1.65
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
Single-molecule studies of the neuronal SNARE fusion machinery. Annu Rev Biochem (2009) 1.55
Detecting the conformation of individual proteins in live cells. Nat Methods (2010) 1.55
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A (2010) 1.51
Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle. Biochemistry (2010) 1.46
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Conformation of the synaptobrevin transmembrane domain. Proc Natl Acad Sci U S A (2006) 1.22
NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR (2008) 1.19
A tripartite SNARE-K+ channel complex mediates in channel-dependent K+ nutrition in Arabidopsis. Plant Cell (2009) 1.18
Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging. J Mol Biol (2009) 1.17
A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly. J Biol Chem (2009) 1.14
Beyond the random coil: stochastic conformational switching in intrinsically disordered proteins. Structure (2011) 1.12
Harnessing the power of the endosome to regulate neural development. Neuron (2012) 1.11
SNARE complex zipping as a driving force in the dilation of proteinaceous fusion pores. J Membr Biol (2010) 1.11
Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol (2007) 1.07
Single Molecule Measurements of Interaction Free Energies Between the Proteins Within Binary and Ternary SNARE Complexes. J Nanoneurosci (2009) 1.06
Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together. Biochemistry (2011) 1.06
Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell (2009) 1.05
Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A (2013) 1.05
A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. Plant Cell (2010) 1.05
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
A novel site of action for alpha-SNAP in the SNARE conformational cycle controlling membrane fusion. Mol Biol Cell (2007) 1.04
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc Natl Acad Sci U S A (2011) 1.04
Clinical uses of botulinum neurotoxins: current indications, limitations and future developments. Toxins (Basel) (2012) 1.04
The SNARE complex from yeast is partially unstructured on the membrane. Structure (2008) 1.01
Receptor and substrate interactions of clostridial neurotoxins. Toxicon (2009) 1.01
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling. Biochemistry (2008) 0.98
Single-molecule observation of helix staggering, sliding, and coiled coil misfolding. Proc Natl Acad Sci U S A (2012) 0.98
Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Mol Biol Cell (2010) 0.96
Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm. Epilepsy Res (2006) 0.95
Engineering botulinum neurotoxin to extend therapeutic intervention. Proc Natl Acad Sci U S A (2009) 0.95
Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex. J Mol Biol (2013) 0.94
A distinct tethering step is vital for vacuole membrane fusion. Elife (2014) 0.93
Identification of a novel Bves function: regulation of vesicular transport. EMBO J (2010) 0.93
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor. Biochem J (2012) 0.92
On the importance of polar interactions for complexes containing intrinsically disordered proteins. PLoS Comput Biol (2013) 0.92
Molecular and immunocytochemical characterization of primary neuronal cultures from adult rat brain: Differential expression of neuronal and glial protein markers. J Neurosci Methods (2009) 0.92
CAPS and Munc13: CATCHRs that SNARE Vesicles. Front Endocrinol (Lausanne) (2013) 0.89
Insights into the different catalytic activities of Clostridium neurotoxins. Biochemistry (2012) 0.89
High cholesterol obviates a prolonged hemifusion intermediate in fast SNARE-mediated membrane fusion. Biophys J (2015) 0.89
Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol (2012) 0.88
The longin SNARE VAMP7/TI-VAMP adopts a closed conformation. J Biol Chem (2010) 0.88
SNAP25 expression in mammalian retinal horizontal cells. J Comp Neurol (2011) 0.88
Individual vesicle fusion events mediated by lipid-anchored DNA. Biophys J (2013) 0.88
Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution. J Membr Biol (2015) 0.87
Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry (2014) 0.87
The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. Biochem J (2013) 0.87
Protein energetics in maturation of the early secretory pathway. Curr Opin Cell Biol (2007) 0.87
Partitioning of synaptotagmin I C2 domains between liquid-ordered and liquid-disordered inner leaflet lipid phases. Biochemistry (2011) 0.87
Sequential analysis of trans-SNARE formation in intracellular membrane fusion. PLoS Biol (2012) 0.86
Atomic force microscope spectroscopy reveals a hemifusion intermediate during soluble N-ethylmaleimide-sensitive factor-attachment protein receptors-mediated membrane fusion. Biophys J (2007) 0.86
A highly tilted membrane configuration for the prefusion state of synaptobrevin. Biophys J (2014) 0.86
Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy. Biochemistry (2013) 0.85
Unique substrate recognition mechanism of the botulinum neurotoxin D light chain. J Biol Chem (2013) 0.85
Dance of the SNAREs: assembly and rearrangements detected with FRET at neuronal synapses. J Neurosci (2013) 0.85
Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice. PLoS One (2011) 0.85
The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding. J Biol Chem (2014) 0.85
Tag team action at the synapse. EMBO Rep (2007) 0.84
Pulling force generated by interacting SNAREs facilitates membrane hemifusion. Integr Biol (Camb) (2009) 0.84
Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering. J Biol Chem (2015) 0.84
Three αSNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF). J Biol Chem (2014) 0.84
The Arabidopsis R-SNARE VAMP721 Interacts with KAT1 and KC1 K+ Channels to Moderate K+ Current at the Plasma Membrane. Plant Cell (2015) 0.83
A novel phase of compressed bilayers that models the prestalk transition state of membrane fusion. Biophys J (2012) 0.83
Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry (2012) 0.82
Intrinsic protein disorder in human pathways. Mol Biosyst (2011) 0.82
Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion. Elife (2015) 0.82
Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release. Epilepsia (2011) 0.81
A tethering complex dimer catalyzes trans-SNARE complex formation in intracellular membrane fusion. Bioarchitecture (2012) 0.80
Synaptotagmin-SNARE coupling enlightened. Nat Struct Mol Biol (2010) 0.80
Characterization of VAMP-2 in the lung: implication in lung surfactant secretion. Cell Biol Int (2012) 0.79
Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. Elife (2015) 0.79
Synaptotagmin 1 and Ca2+ drive trans SNARE zippering. Sci Rep (2014) 0.78
The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum. Eukaryot Cell (2009) 0.78
Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the Drosophila neuromuscular junction. PLoS One (2010) 0.78
Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis. J Biol Chem (2012) 0.78
Investigation of SNARE-Mediated Membrane Fusion Mechanism Using Atomic Force Microscopy. Jpn J Appl Phys (2008) (2009) 0.76
Illuminating membrane fusion. Proc Natl Acad Sci U S A (2006) 0.75
A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection. PLoS One (2014) 0.75
Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxication. Sci Rep (2015) 0.75