Published in Biochemistry on March 02, 2010
Molecular machines governing exocytosis of synaptic vesicles. Nature (2012) 3.66
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
At the junction of SNARE and SM protein function. Curr Opin Cell Biol (2010) 1.65
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A (2010) 1.51
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure (2011) 1.32
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A (2010) 1.22
Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex. Mol Biol Cell (2012) 1.20
A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science (2015) 1.18
Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Mol Biol Cell (2011) 1.16
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proc Natl Acad Sci U S A (2013) 1.16
Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J (2012) 1.11
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc Natl Acad Sci U S A (2011) 1.04
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc Natl Acad Sci U S A (2013) 1.03
Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay. J Biol Chem (2011) 1.02
Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A (2013) 1.01
Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion. J Biol Chem (2010) 1.00
Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Mol Biol Cell (2011) 1.00
Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*. PLoS One (2013) 0.99
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells. Front Immunol (2014) 0.94
Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex. J Mol Biol (2013) 0.94
An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly. J Biol Chem (2014) 0.93
SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion. EMBO Rep (2014) 0.93
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. J Biol Chem (2012) 0.90
Membrane bridging and hemifusion by denaturated Munc18. PLoS One (2011) 0.89
Organization of SNAREs within the Golgi stack. Cold Spring Harb Perspect Biol (2011) 0.88
Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol (2012) 0.88
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner. J Cell Biol (2014) 0.87
Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation. J Immunol (2013) 0.87
The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis. Nat Commun (2015) 0.85
Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering. J Biol Chem (2015) 0.84
Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin. J Biol Chem (2015) 0.83
Vesicle fusion probability is determined by the specific interactions of munc18. J Biol Chem (2010) 0.81
Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis. PLoS One (2011) 0.81
Sec1p and Mso1p C-terminal tails cooperate with the SNAREs and Sec4p in polarized exocytosis. Mol Biol Cell (2010) 0.81
Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis. BMC Syst Biol (2012) 0.79
A pivotal role for pro-335 in balancing the dual functions of Munc18-1 domain-3a in regulated exocytosis. J Biol Chem (2014) 0.76
Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis. EMBO J (2017) 0.75
SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins. Nat Struct Mol Biol (2015) 0.75
Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1. Mol Genet Genomic Med (2017) 0.75
UNC-18 and Tomosyn antagonistically control synaptic vesicle priming downstream of UNC-13 in C. elegans. J Neurosci (2017) 0.75
An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly. EMBO J (2017) 0.75
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature (1998) 15.80
SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol (2006) 12.74
The synaptic vesicle cycle. Annu Rev Neurosci (2004) 12.25
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96
Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science (2000) 5.89
Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell (1997) 5.72
A conformational switch in syntaxin during exocytosis: role of munc18. EMBO J (1999) 5.07
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature (1993) 4.93
Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell (2007) 4.26
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat Struct Biol (1998) 3.74
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell (1998) 3.40
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol (1999) 3.31
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Structure and function of SNARE and SNARE-interacting proteins. Q Rev Biophys (2005) 3.01
Vam3p structure reveals conserved and divergent properties of syntaxins. Nat Struct Biol (2001) 2.92
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release. Trends Cell Biol (2006) 2.84
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p. EMBO J (2006) 2.52
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
nSec1 binds a closed conformation of syntaxin1A. J Cell Biol (2000) 2.44
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J (2008) 2.33
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. EMBO J (2002) 2.20
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
Ordering the final events in yeast exocytosis. J Cell Biol (2000) 2.03
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes. J Cell Biol (2002) 1.92
Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking. Traffic (2006) 1.88
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
HOPS proofreads the trans-SNARE complex for yeast vacuole fusion. Mol Biol Cell (2008) 1.78
The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes. J Cell Biol (2006) 1.76
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Biochemistry (2008) 1.67
Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc Natl Acad Sci U S A (2002) 1.37
Munc18a scaffolds SNARE assembly to promote membrane fusion. Mol Biol Cell (2008) 1.36
Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p. Proc Natl Acad Sci U S A (2006) 1.34
NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin. J Biomol NMR (1999) 1.31
Regulated exocytosis: merging ideas on fusing membranes. Curr Opin Cell Biol (2007) 1.19
NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR (2008) 1.19
The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis. Structure (2000) 1.18
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science (2012) 2.70
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J (2005) 1.91
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J (2005) 1.86
A protein sequence that can encode native structure by disfavoring alternate conformations. Nat Struct Biol (2002) 1.85
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
A minimal domain responsible for Munc13 activity. Nat Struct Mol Biol (2005) 1.68
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Biochemistry (2008) 1.67
At the junction of SNARE and SM protein function. Curr Opin Cell Biol (2010) 1.65
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol (2010) 1.63
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proc Natl Acad Sci U S A (2002) 1.37
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. Proc Natl Acad Sci U S A (2009) 1.37
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1. J Biol Chem (2006) 1.34
Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci (2010) 1.34
Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci (2002) 1.32
The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors. Structure (2011) 1.32
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem (2005) 1.29
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proc Natl Acad Sci U S A (2008) 1.29
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nat Struct Mol Biol (2004) 1.26
Facile detection of protein-protein interactions by one-dimensional NMR spectroscopy. Biochemistry (2003) 1.25
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells. Nat Neurosci (2002) 1.25
The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly. J Biol Chem (2002) 1.25
Remote homology between Munc13 MUN domain and vesicle tethering complexes. J Mol Biol (2009) 1.24
NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR (2008) 1.19
Structural analysis of conserved oligomeric Golgi complex subunit 2. J Biol Chem (2007) 1.15
Complexin/synaptotagmin interplay controls acrosomal exocytosis. J Biol Chem (2007) 1.15
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J (2006) 1.11
Solution structure of the Vam7p PX domain. Biochemistry (2002) 1.10
Physical and functional interactions of SNAP-23 with annexin A2. Am J Respir Cell Mol Biol (2007) 1.06
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc Natl Acad Sci U S A (2011) 1.04
Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells. Neuropharmacology (2003) 0.99
Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif. Traffic (2003) 0.97
Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J Cell Sci (2011) 0.97
Three-dimensional structure of the rSly1 N-terminal domain reveals a conformational change induced by binding to syntaxin 5. J Mol Biol (2004) 0.96
Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I. Diabetes (2002) 0.94
Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1. Biochemistry (2005) 0.94
Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex. J Mol Biol (2013) 0.94
Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry (2004) 0.92
NMR structure and calcium-binding properties of the tellurite resistance protein TerD from Klebsiella pneumoniae. J Mol Biol (2010) 0.92
Prevalent mechanism of membrane bridging by synaptotagmin-1. Proc Natl Acad Sci U S A (2013) 0.90
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution. Biochemistry (2005) 0.89
Membrane bridging and hemifusion by denaturated Munc18. PLoS One (2011) 0.89
Regulation of lung surfactant secretion by microRNA-150. Biochem Biophys Res Commun (2012) 0.88
Are neuronal SNARE proteins Ca2+ sensors? J Mol Biol (2005) 0.88
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PLoS One (2010) 0.88
Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. J Mol Biol (2005) 0.87
SNARE function revisited. Nat Struct Biol (2003) 0.86
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS One (2010) 0.85
Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy. Biochemistry (2013) 0.85
Unexpected Ca2+-binding properties of synaptotagmin 9. Proc Natl Acad Sci U S A (2004) 0.84
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Proc Natl Acad Sci U S A (2012) 0.84
Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. Biochemistry (2007) 0.83
NMR measurement of the off rate from the first calcium-binding site of the synaptotagmin I C2A domain. FEBS Lett (2002) 0.83
How much can SNAREs flex their muscles? Nat Struct Mol Biol (2007) 0.82
Annexin A2 interactions with Rab14 in alveolar type II cells. J Biol Chem (2008) 0.81
Synaptotagmin-SNARE coupling enlightened. Nat Struct Mol Biol (2010) 0.80
A dynamic t-SNARE complex. Structure (2008) 0.79
UTP regulation of ion transport in alveolar epithelial cells involves distinct mechanisms. Am J Physiol Lung Cell Mol Physiol (2009) 0.78
Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease. Metallomics (2014) 0.75