Published in J Virol on January 01, 2006
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The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase. J Biol Chem (2010) 1.06
Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding. J Mol Biol (2006) 1.04
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Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus. J Virol (2011) 0.97
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A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities. Methods Mol Biol (2010) 0.87
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Antiviral Res (2012) 0.86
Spatiotemporal analysis of hepatitis C virus infection. PLoS Pathog (2015) 0.85
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci (2015) 0.83
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The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus. J Virol (2014) 0.81
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Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor. Antimicrob Agents Chemother (2011) 0.80
pH-dependent conformational changes in the HCV NS3 protein modulate its ATPase and helicase activities. PLoS One (2014) 0.79
Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems. Antimicrob Agents Chemother (2012) 0.79
Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance. Antimicrob Agents Chemother (2014) 0.78
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. J Biol Chem (2013) 0.78
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase. Br J Pharmacol (2015) 0.78
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Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge. Mar Drugs (2014) 0.77
Computational study on the inhibitor binding mode and allosteric regulation mechanism in hepatitis C virus NS3/4A protein. PLoS One (2014) 0.76
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Step-by-step progress toward understanding the hepatitis C virus RNA helicase. Hepatology (2006) 0.75
Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient. PLoS One (2015) 0.75
The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action. J Biol Chem (2016) 0.75
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Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action. J Biol Chem (2003) 1.34
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Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding. Nucleic Acids Res (2004) 1.11
Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity. Biochemistry (2000) 1.05
Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations. Nucleic Acids Res (2004) 1.03
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Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action. J Biol Chem (2003) 1.34
Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties. J Virol (2003) 1.31
Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level. J Virol (2008) 1.28
Monitoring helicase activity with molecular beacons. Biotechniques (2008) 1.19
DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. Nucleic Acids Res (2008) 1.13
Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding. Nucleic Acids Res (2004) 1.11
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The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. Biochemistry (2010) 1.01
Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C. Future Virol (2009) 1.01
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays. Nucleic Acids Res (2012) 1.00
Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes. Antimicrob Agents Chemother (2008) 1.00
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor. Biochemistry (2010) 1.00
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. J Antimicrob Chemother (2012) 1.00
Fuel specificity of the hepatitis C virus NS3 helicase. J Mol Biol (2009) 0.93
Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. J Med Chem (2012) 0.92
Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase. Methods Enzymol (2012) 0.91
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities. Protein Sci (2013) 0.88
Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. Biochem Pharmacol (2009) 0.86
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Antiviral Res (2012) 0.86
Discovering new medicines targeting helicases: challenges and recent progress. J Biomol Screen (2013) 0.85
An ire1-phk1 chimera reveals a dispensable role of autokinase activity in endoplasmic reticulum stress response. J Mol Biol (2013) 0.84
Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication. ACS Chem Biol (2014) 0.83
Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP. Biochemistry (2013) 0.82
Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Infect Dis (2011) 0.81
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. J Biol Chem (2013) 0.78
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy. ACS Chem Biol (2015) 0.75