Published in Trends Microbiol on December 13, 2005
A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate. Proc Natl Acad Sci U S A (2007) 3.49
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol (2007) 2.68
Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol (2009) 2.62
Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape. J Leukoc Biol (2006) 2.10
Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun (2007) 2.09
ppGpp conjures bacterial virulence. Microbiol Mol Biol Rev (2010) 1.97
Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2. BMC Microbiol (2006) 1.88
Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor. J Leukoc Biol (2006) 1.80
Acquisition of the vacuolar ATPase proton pump and phagosome acidification are essential for escape of Francisella tularensis into the macrophage cytosol. Infect Immun (2008) 1.77
MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection. Proc Natl Acad Sci U S A (2013) 1.54
Role of the wbt locus of Francisella tularensis in lipopolysaccharide O-antigen biogenesis and pathogenicity. Infect Immun (2006) 1.53
Identification of an essential Francisella tularensis subsp. tularensis virulence factor. Infect Immun (2008) 1.50
Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis. Immunol Rev (2008) 1.48
The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens. Infect Immun (2006) 1.42
Genome-wide screen in Francisella novicida for genes required for pulmonary and systemic infection in mice. Infect Immun (2008) 1.39
Structural heterogeneity and environmentally regulated remodeling of Francisella tularensis subspecies novicida lipid A characterized by tandem mass spectrometry. J Am Soc Mass Spectrom (2007) 1.37
Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infect Immun (2009) 1.25
Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulence. Infect Immun (2008) 1.23
Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun (2009) 1.21
Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence. Infect Immun (2008) 1.19
Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PLoS One (2011) 1.14
Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice. Mol Immunol (2008) 1.11
Regulation of virulence gene transcripts by the Francisella novicida orphan response regulator PmrA: role of phosphorylation and evidence of MglA/SspA interaction. Infect Immun (2010) 1.11
Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals. Front Microbiol (2011) 1.07
An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun (2007) 1.07
Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. PLoS One (2010) 1.07
Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis. Environ Microbiol (2010) 1.07
Intracellular pathogenic bacteria and fungi--a case of convergent evolution? Nat Rev Microbiol (2008) 1.06
Exploitation of host cell biology and evasion of immunity by francisella tularensis. Front Microbiol (2011) 1.05
Molecular bases of proliferation of Francisella tularensis in arthropod vectors. Environ Microbiol (2010) 1.03
Detection of a novel subspecies of Francisella noatunensis as endosymbiont of the ciliate Euplotes raikovi. Microb Ecol (2010) 1.02
New protein fold revealed by a 1.65 A resolution crystal structure of Francisella tularensis pathogenicity island protein IglC. Protein Sci (2007) 0.98
Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. orientalis Toba04 gives novel insights into Francisella evolution and pathogenecity. BMC Genomics (2012) 0.97
Prison break: pathogens' strategies to egress from host cells. Microbiol Mol Biol Rev (2012) 0.97
Repression of inflammasome by Francisella tularensis during early stages of infection. J Biol Chem (2013) 0.95
Francisella tularensis regulates autophagy-related host cell signaling pathways. Autophagy (2009) 0.95
Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway. PLoS One (2009) 0.95
Regulation of apoptosis and anti-apoptosis signalling by Francisella tularensis. Microbes Infect (2009) 0.94
A Francisella tularensis locus required for spermine responsiveness is necessary for virulence. Infect Immun (2011) 0.92
The inflammasomes: molecular effectors of host resistance against bacterial, viral, parasitic, and fungal infections. Front Microbiol (2011) 0.92
Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol (2014) 0.90
Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorg Med Chem Lett (2009) 0.89
Contribution of citrulline ureidase to Francisella tularensis strain Schu S4 pathogenesis. J Bacteriol (2009) 0.88
Francisella novicida pathogenicity island encoded proteins were secreted during infection of macrophage-like cells. PLoS One (2014) 0.87
Genome-wide RNAi screen in IFN-γ-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One (2012) 0.85
Francisella tularensis uses cholesterol and clathrin-based endocytic mechanisms to invade hepatocytes. Sci Rep (2011) 0.84
The acid phosphatase AcpA is secreted in vitro and in macrophages by Francisella spp. Infect Immun (2011) 0.84
EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice. Mol Microbiol (2014) 0.84
SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. J Comb Chem (2010) 0.83
IglC and PdpA are important for promoting Francisella invasion and intracellular growth in epithelial cells. PLoS One (2014) 0.81
IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection. PLoS One (2013) 0.80
Elucidation of a mechanism of oxidative stress regulation in Francisella tularensis live vaccine strain. Mol Microbiol (2016) 0.76
RX-P873, a Novel Protein Synthesis Inhibitor, Accumulates in Human THP-1 Monocytes and Is Active against Intracellular Infections by Gram-Positive (Staphylococcus aureus) and Gram-Negative (Pseudomonas aeruginosa) Bacteria. Antimicrob Agents Chemother (2015) 0.75
Importance of Metabolic Adaptations in Francisella Pathogenesis. Front Cell Infect Microbiol (2017) 0.75
Entry of Francisella tularensis into Murine B Cells: The Role of B Cell Receptors and Complement Receptors. PLoS One (2015) 0.75
The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella. Nat Commun (2017) 0.75
A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol (2004) 4.67
MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc Natl Acad Sci U S A (2004) 4.14
The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol (2005) 3.51
Vibrio cholerae and cholera: out of the water and into the host. FEMS Microbiol Rev (2002) 3.39
Amoebae as training grounds for intracellular bacterial pathogens. Appl Environ Microbiol (2005) 2.59
Modulation of biogenesis of the Francisella tularensis subsp. novicida-containing phagosome in quiescent human macrophages and its maturation into a phagolysosome upon activation by IFN-gamma. Cell Microbiol (2005) 2.46
Allelic exchange in Francisella tularensis using PCR products. FEMS Microbiol Lett (2003) 2.29
The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression. Infect Immun (2008) 2.12
The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol (2009) 2.02
Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India. J Clin Microbiol (2009) 1.82
Acquisition of the vacuolar ATPase proton pump and phagosome acidification are essential for escape of Francisella tularensis into the macrophage cytosol. Infect Immun (2008) 1.77
Host proteasomal degradation generates amino acids essential for intracellular bacterial growth. Science (2011) 1.69
Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis. Microbiology (2010) 1.67
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa. Mol Microbiol (2008) 1.61
The sodium-driven flagellar motor controls exopolysaccharide expression in Vibrio cholerae. J Bacteriol (2004) 1.58
Functional diversity of ankyrin repeats in microbial proteins. Trends Microbiol (2009) 1.58
A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell Microbiol (2007) 1.57
Regulation of virulence in Vibrio cholerae: the ToxR regulon. Future Microbiol (2007) 1.53
Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophila. J Exp Med (2010) 1.52
Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome. Cell Microbiol (2004) 1.48
The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors. J Bacteriol (2009) 1.45
Roles of the regulatory proteins FlhF and FlhG in the Vibrio cholerae flagellar transcription hierarchy. J Bacteriol (2005) 1.45
Incomplete activation of macrophage apoptosis during intracellular replication of Legionella pneumophila. Infect Immun (2005) 1.44
Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape. Infect Immun (2008) 1.42
Molecular and genetic basis of pathogenesis in Francisella tularensis. Ann N Y Acad Sci (2007) 1.41
Acanthamoeba polyphaga resuscitates viable non-culturable Legionella pneumophila after disinfection. Environ Microbiol (2007) 1.30
Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia. Infect Immun (2006) 1.27
Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster. Infect Immun (2002) 1.25
Characterization of functional domains of the Vibrio cholerae virulence regulator ToxT. Mol Microbiol (2005) 1.23
Targeted inactivation of francisella tularensis genes by group II introns. Appl Environ Microbiol (2008) 1.22
Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A (2008) 1.21
Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection. Antimicrob Agents Chemother (2004) 1.20
Characterization of the Francisella tularensis subsp. novicida type IV pilus. Microbiology (2008) 1.18
Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS Microbiol Lett (2003) 1.17
Cell biology and molecular ecology of Francisella tularensis. Cell Microbiol (2009) 1.17
Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella. Trends Microbiol (2012) 1.16
Role of Vibrio cholerae O139 surface polysaccharides in intestinal colonization. Infect Immun (2002) 1.13
Indispensable role for the eukaryotic-like ankyrin domains of the ankyrin B effector of Legionella pneumophila within macrophages and amoebae. Infect Immun (2010) 1.12
Oral live vaccine strain-induced protective immunity against pulmonary Francisella tularensis challenge is mediated by CD4+ T cells and antibodies, including immunoglobulin A. Clin Vaccine Immunol (2009) 1.12
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. Proc Natl Acad Sci U S A (2009) 1.11
Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition. Mol Microbiol (2011) 1.10
Vibrio cholerae OmpU and OmpT porins are differentially affected by bile. Infect Immun (2002) 1.10
Early trafficking and intracellular replication of Legionella longbeachaea within an ER-derived late endosome-like phagosome. Cell Microbiol (2007) 1.09
Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. PLoS One (2010) 1.07
Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis. Environ Microbiol (2010) 1.07
Identification of residues critical for the function of the Vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis. J Mol Biol (2007) 1.07
Construction of targeted insertion mutations in Francisella tularensis subsp. novicida. Biotechniques (2007) 1.06
Amoeba host-Legionella synchronization of amino acid auxotrophy and its role in bacterial adaptation and pathogenic evolution. Environ Microbiol (2013) 1.04
Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis. Mol Cell Proteomics (2006) 1.03
Molecular bases of proliferation of Francisella tularensis in arthropod vectors. Environ Microbiol (2010) 1.03
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge. Vaccine (2009) 1.03
Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages. Infect Immun (2005) 1.02
Host-dependent trigger of caspases and apoptosis by Legionella pneumophila. Infect Immun (2007) 1.01
The Vibrio cholerae porins OmpU and OmpT have distinct channel properties. J Biol Chem (2003) 1.00
N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids. J Biol Chem (2011) 1.00
Cellular microbiology and molecular ecology of Legionella-amoeba interaction. Virulence (2013) 0.99
The Vibrio cholerae FlgM homologue is an anti-sigma28 factor that is secreted through the sheathed polar flagellum. J Bacteriol (2004) 0.98
Targeted gene disruption in Francisella tularensis by group II introns. Methods (2009) 0.98
The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies. PLoS One (2010) 0.97
Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells. Infect Immun (2007) 0.97
Characterization of enhancer binding by the Vibrio cholerae flagellar regulatory protein FlrC. J Bacteriol (2005) 0.97
The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa. Infect Immun (2008) 0.97
A bacterial hemerythrin domain regulates the activity of a Vibrio cholerae diguanylate cyclase. Biochemistry (2012) 0.95
Genetic susceptibility and caspase activation in mouse and human macrophages are distinct for Legionella longbeachae and L. pneumophila. Infect Immun (2007) 0.94
Molecular and cell biology of Legionella pneumophila. Int J Med Microbiol (2004) 0.92
Role for RpoS but not RelA of Legionella pneumophila in modulation of phagosome biogenesis and adaptation to the phagosomal microenvironment. Infect Immun (2006) 0.92
Vibrio2005: the First International Conference on the Biology of Vibrios. J Bacteriol (2006) 0.92
Genetic manipulation of francisella tularensis. Front Microbiol (2011) 0.91
Lipidation of an FlrC-dependent protein is required for enhanced intestinal colonization by Vibrio cholerae. J Bacteriol (2007) 0.91
An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site. Biochemistry (2013) 0.90
How does Legionella pneumophila exit the host cell? Trends Microbiol (2002) 0.89
Cyclic di-GMP stimulates biofilm formation and inhibits virulence of Francisella novicida. Infect Immun (2012) 0.89
Temporal and differential regulation of expression of the eukaryotic-like ankyrin effectors of Legionella pneumophila. Environ Microbiol Rep (2010) 0.89
Mucosal immunization with live attenuated Francisella novicida U112ΔiglB protects against pulmonary F. tularensis SCHU S4 in the Fischer 344 rat model. PLoS One (2012) 0.87
CD4+ T cells are required during priming but not the effector phase of antibody-mediated IFN-gamma-dependent protective immunity against pulmonary Francisella novicida infection. Immunol Cell Biol (2008) 0.87
Evasion of IFN-γ signaling by Francisella novicida is dependent upon Francisella outer membrane protein C. PLoS One (2011) 0.86
Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation. PLoS One (2011) 0.86
A novel regulatory protein involved in motility of Vibrio cholerae. J Bacteriol (2009) 0.85
Draft Genome Sequence of the Fish Pathogen Piscirickettsia salmonis. Genome Announc (2013) 0.85
The ToxT-dependent methyl-accepting chemoreceptors AcfB and TcpI contribute to Vibrio cholerae intestinal colonization. FEMS Microbiol Lett (2009) 0.84
Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol. Cell Microbiol (2010) 0.82
Characterizing lipopolysaccharide and core lipid A mutant O1 and O139 Vibrio cholerae strains for adherence properties on mucus-producing cell line HT29-Rev MTX and virulence in mice. Int J Med Microbiol (2005) 0.82
Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol (2012) 0.82
The complexity of ToxT-dependent transcription in Vibrio cholerae. Indian J Med Res (2011) 0.81
Rapid nutritional remodeling of the host cell upon attachment of Legionella pneumophila. Infect Immun (2013) 0.81
Characterization of Legionella pneumophila pmiA, a gene essential for infectivity of protozoa and macrophages. Infect Immun (2005) 0.81
A bacterial two-hybrid system that utilizes Gateway cloning for rapid screening of protein-protein interactions. Biotechniques (2010) 0.81
Complete and ubiquitinated proteome of the Legionella-containing vacuole within human macrophages. J Proteome Res (2014) 0.81
Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence. Pathog Dis (2014) 0.81
Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clin Vaccine Immunol (2009) 0.79
Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain. Infect Immun (2012) 0.79
Proteome cataloging and relative quantification of Francisella tularensis tularensis strain Schu4 in 2D PAGE using preparative isoelectric focusing. J Proteome Res (2007) 0.78
Vibrio2009: the third international conference on the biology of Vibrios. Mol Microbiol (2010) 0.78
Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets. Expert Opin Biol Ther (2003) 0.76
Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense. Infect Immun (2011) 0.76