Published in Infect Immun on February 09, 2009
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development. Microbiol Mol Biol Rev (2009) 1.59
Subversion of host recognition and defense systems by Francisella spp. Microbiol Mol Biol Rev (2012) 1.40
The many roles of NOX2 NADPH oxidase-derived ROS in immunity. Semin Immunopathol (2010) 1.36
Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun (2010) 1.23
Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun (2009) 1.21
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol (2010) 1.18
Genome-wide identification of genes required for fitness of group A Streptococcus in human blood. Infect Immun (2013) 1.18
Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo. Infect Immun (2010) 1.17
Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PLoS One (2011) 1.14
The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation. Front Microbiol (2010) 1.14
Francisella tularensis metabolism and its relation to virulence. Front Microbiol (2010) 1.13
Mechanisms of Francisella tularensis intracellular pathogenesis. Cold Spring Harb Perspect Med (2013) 1.10
Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLoS One (2012) 1.08
Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis. Infect Immun (2011) 1.08
Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes. J Immunol (2010) 1.07
Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis. Environ Microbiol (2010) 1.07
Exploitation of host cell biology and evasion of immunity by francisella tularensis. Front Microbiol (2011) 1.05
Directed screen of Francisella novicida virulence determinants using Drosophila melanogaster. Infect Immun (2010) 1.04
Regulation of francisella tularensis virulence. Front Microbiol (2011) 1.03
IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS. Infect Immun (2011) 1.02
Are reactive oxygen species always detrimental to pathogens? Antioxid Redox Signal (2013) 0.95
Link between intraphagosomal biotin and rapid phagosomal escape in Francisella. Proc Natl Acad Sci U S A (2012) 0.94
Environmental adaptation of Francisella tularensis. Microbes Infect (2009) 0.93
Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. J Leukoc Biol (2012) 0.93
Toll-like receptor 3 agonist protection against experimental Francisella tularensis respiratory tract infection. Infect Immun (2010) 0.93
Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC. Infect Immun (2012) 0.93
Host Defense and the Airway Epithelium: Frontline Responses That Protect against Bacterial Invasion and Pneumonia. J Pathog (2011) 0.92
NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol Microbiol (2012) 0.90
Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol (2014) 0.90
Neutrophils: potential therapeutic targets in tularemia? Front Cell Infect Microbiol (2013) 0.86
Effects of the putative transcriptional regulator IclR on Francisella tularensis pathogenesis. Infect Immun (2010) 0.86
The RNA chaperone Hfq is important for growth and stress tolerance in Francisella novicida. PLoS One (2011) 0.85
Importance of branched-chain amino acid utilization in Francisella intracellular adaptation. Infect Immun (2014) 0.84
Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun (2014) 0.84
The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection. J Bacteriol (2012) 0.84
The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS. Front Microbiol (2011) 0.83
Role of pathogenicity determinant protein C (PdpC) in determining the virulence of the Francisella tularensis subspecies tularensis SCHU. PLoS One (2014) 0.81
Use of a capture-based pathogen transcript enrichment strategy for RNA-Seq analysis of the Francisella tularensis LVS transcriptome during infection of murine macrophages. PLoS One (2013) 0.81
Differential expression of microRNAs in Francisella tularensis-infected human macrophages: miR-155-dependent downregulation of MyD88 inhibits the inflammatory response. PLoS One (2014) 0.80
Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages. Front Microbiol (2013) 0.80
Antioxidant Defenses of Francisella tularensis Modulate Macrophage Function and Production of Proinflammatory Cytokines. J Biol Chem (2015) 0.79
Immunofluorescence and confocal microscopy of neutrophils. Methods Mol Biol (2014) 0.77
Multifaceted effects of Francisella tularensis on human neutrophil function and lifespan. Immunol Rev (2016) 0.76
Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida. PLoS One (2016) 0.75
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Phagocytosis of microbes: complexity in action. Annu Rev Immunol (2001) 5.49
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med (2005) 5.00
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proc Natl Acad Sci U S A (1992) 4.88
An outbreak of primary pneumonic tularemia on Martha's Vineyard. N Engl J Med (2001) 4.60
An attenuated strain of the facultative intracellular bacterium Francisella tularensis can escape the phagosome of monocytic cells. Infect Immun (2003) 4.37
Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med (2007) 4.32
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun (2004) 4.31
Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol (1993) 4.23
Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes. J Exp Med (1983) 3.96
AEROSOL INFECTION OF MAN WITH PASTEURELLA TULARENSIS. Bacteriol Rev (1961) 3.62
The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol (2005) 3.51
MglA and MglB are required for the intramacrophage growth of Francisella novicida. Mol Microbiol (1998) 3.29
Respiratory burst in human neutrophils. J Immunol Methods (1999) 3.16
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release. Proc Natl Acad Sci U S A (2005) 2.82
The Francisella pathogenicity island protein IglA localizes to the bacterial cytoplasm and is needed for intracellular growth. BMC Microbiol (2007) 2.81
Construction and characterization of a highly efficient Francisella shuttle plasmid. Appl Environ Microbiol (2004) 2.71
Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare. Annu Rev Microbiol (2006) 2.68
Factors affecting the escape of Francisella tularensis from the phagolysosome. J Med Microbiol (2004) 2.57
Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growth. Infect Immun (1995) 2.52
Innate and adaptive immunity to Francisella. Ann N Y Acad Sci (2007) 2.32
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol (1996) 2.31
NADPH oxidase activation and assembly during phagocytosis. J Immunol (1999) 2.31
The inflammasome in pathogen recognition and inflammation. J Leukoc Biol (2007) 2.28
Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape. J Leukoc Biol (2006) 2.10
Characterization and sequencing of a respiratory burst-inhibiting acid phosphatase from Francisella tularensis. J Biol Chem (1996) 2.08
The Francisella pathogenicity island. Ann N Y Acad Sci (2007) 2.07
Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol (2001) 2.04
Macrophage variants in oxygen metabolism. J Exp Med (1980) 2.04
Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem (1998) 1.99
Francisella tularensis enters macrophages via a novel process involving pseudopod loops. Infect Immun (2005) 1.95
Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog (2007) 1.92
Francisella tularensis travels a novel, twisted road within macrophages. Trends Microbiol (2005) 1.91
Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2. BMC Microbiol (2006) 1.88
Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol (2007) 1.87
Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor. J Leukoc Biol (2006) 1.80
Expression of IglC is necessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis. Microb Pathog (2004) 1.75
Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge. Infect Immun (2006) 1.73
Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. J Exp Med (2000) 1.69
Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages. Infect Immun (2006) 1.68
Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG. Infect Immun (2007) 1.64
In vivo Himar1-based transposon mutagenesis of Francisella tularensis. Appl Environ Microbiol (2006) 1.63
The mannose receptor mediates uptake of pathogenic and nonpathogenic mycobacteria and bypasses bactericidal responses in human macrophages. Infect Immun (1999) 1.61
Francisella tularensis: unravelling the secrets of an intracellular pathogen. J Med Microbiol (2008) 1.57
The live vaccine strain of Francisella tularensis replicates in human and murine macrophages but induces only the human cells to secrete proinflammatory cytokines. J Leukoc Biol (2005) 1.56
Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J Leukoc Biol (2006) 1.52
Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages. Am J Respir Cell Mol Biol (1996) 1.52
MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages. Infect Immun (2008) 1.49
Toll-like receptors: networking for success. Eur J Immunol (2003) 1.45
Identification of fevR, a novel regulator of virulence gene expression in Francisella novicida. Infect Immun (2008) 1.44
Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release. J Immunol (2005) 1.42
Molecular and genetic basis of pathogenesis in Francisella tularensis. Ann N Y Acad Sci (2007) 1.41
The contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophages. Microbes Infect (2005) 1.41
Uptake and intracellular fate of Francisella tularensis in human macrophages. Ann N Y Acad Sci (2007) 1.40
Aggregation of host endosomes by Salmonella requires SPI2 translocation of SseFG and involves SpvR and the fms-aroE intragenic region. Mol Microbiol (2000) 1.40
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS One (2008) 1.39
AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence. Infect Immun (2006) 1.39
Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors. Cell Microbiol (2006) 1.34
Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulence. J Bacteriol (2006) 1.33
Role of urease in megasome formation and Helicobacter pylori survival in macrophages. J Leukoc Biol (2006) 1.25
Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay. J Immunol (1989) 1.23
Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. Appl Environ Microbiol (2008) 1.20
VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Mol Cell Biol (2001) 1.18
MglA regulates Francisella tularensis subsp. novicida (Francisella novicida) response to starvation and oxidative stress. J Bacteriol (2007) 1.17
Protein kinase C regulates MARCKS cycling between the plasma membrane and lysosomes in fibroblasts. EMBO J (1995) 1.17
To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils. Immunol Rev (2007) 1.14
Identification of a Francisella tularensis LVS outer membrane protein that confers adherence to A549 human lung cells. FEMS Microbiol Lett (2006) 1.09
Role of primary human alveolar epithelial cells in host defense against Francisella tularensis infection. Infect Immun (2007) 1.08
An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun (2007) 1.07
Extent of genetic lesions of the arginine and pyrimidine biosynthetic pathways in Lactobacillus plantarum, L. paraplantarum, L. pentosus, and L. casei: prevalence of CO(2)-dependent auxotrophs and characterization of deficient arg genes in L. plantarum. Appl Environ Microbiol (2003) 1.07
Francisella tularensis invasion of lung epithelial cells. Infect Immun (2008) 1.05
The respiratory burst-inhibiting acid phosphatase AcpA is not essential for the intramacrophage growth or virulence of Francisella novicida. FEMS Microbiol Lett (1999) 1.04
Construction of a Francisella tularensis two-dimensional electrophoresis protein database. Proteomics (2001) 0.99
Superoxide release and NADPH oxidase components in mature human phagocytes: correlation between functional capacity and amount of functional proteins. Biochem Biophys Res Commun (1996) 0.93
Further evidence that lucigenin-derived chemiluminescence monitors mitochondrial superoxide generation in rat alveolar macrophages. Free Radic Biol Med (1994) 0.92
Differentiation of human peripheral blood monocytes to macrophages is associated with changes in the cellular respiratory burst activity. Cell Biochem Funct (1992) 0.84
Role of macrophage complement and lectin-like receptors in binding Leishmania parasites to host macrophages. Immunol Lett (1985) 0.83
Lucigenin chemiluminescence and its relationship to mitochondrial respiration in phagocytic cells. Biochem Biophys Res Commun (1989) 0.81
Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare. Annu Rev Microbiol (2006) 2.68
Francisella tularensis LVS evades killing by human neutrophils via inhibition of the respiratory burst and phagosome escape. J Leukoc Biol (2006) 2.10
Protocols for production of selenomethionine-labeled proteins in 2-L polyethylene terephthalate bottles using auto-induction medium. Protein Expr Purif (2005) 2.02
Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor. J Leukoc Biol (2006) 1.80
The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cell Microbiol (2002) 1.42
HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype. Infect Immun (2003) 1.42
Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun (2004) 1.36
Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol (2010) 1.33
Differential binding to and biofilm formation on, HEp-2 cells by Salmonella enterica serovar Typhimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster. Mol Microbiol (2002) 1.32
The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Mol Ther (2008) 1.31
Exopolysaccharide sugars contribute to biofilm formation by Salmonella enterica serovar typhimurium on HEp-2 cells and chicken intestinal epithelium. J Bacteriol (2005) 1.28
Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. PLoS One (2010) 1.26
Role of urease in megasome formation and Helicobacter pylori survival in macrophages. J Leukoc Biol (2006) 1.25
Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun (2010) 1.23
Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun (2009) 1.21
Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. Appl Environ Microbiol (2008) 1.20
Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators. J Bacteriol (2003) 1.20
Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol (2010) 1.18
Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan. J Immunol (2012) 1.18
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J (2007) 1.17
Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells. Infect Immun (2004) 1.17
Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes. J Immunol (2009) 1.17
To activate or not to activate: distinct strategies used by Helicobacter pylori and Francisella tularensis to modulate the NADPH oxidase and survive in human neutrophils. Immunol Rev (2007) 1.14
Multicenter clinical evaluation of the illumigene group A Streptococcus DNA amplification assay for detection of group A Streptococcus from pharyngeal swabs. J Clin Microbiol (2013) 1.13
Real-time detection of influenza a, influenza B, and respiratory syncytial virus a and B in respiratory specimens by use of nanoparticle probes. J Clin Microbiol (2010) 1.09
An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun (2007) 1.07
Salmonella enterica serovar Typhimurium requires the Lpf, Pef, and Tafi fimbriae for biofilm formation on HEp-2 tissue culture cells and chicken intestinal epithelium. Infect Immun (2006) 1.07
The fimYZ genes regulate Salmonella enterica Serovar Typhimurium invasion in addition to type 1 fimbrial expression and bacterial motility. Infect Immun (2005) 1.06
Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum. J Immunol (2012) 1.00
Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells. Life Sci (2002) 0.98
Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. J Leukoc Biol (2012) 0.93
Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC. Infect Immun (2012) 0.93
Effects of solid-medium type on routine identification of bacterial isolates by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol (2011) 0.93
Multicenter clinical evaluation of VRESelect agar for identification of vancomycin-resistant Enterococcus faecalis and Enterococcus faecium. J Clin Microbiol (2013) 0.91
Comparison of the BD MAX enteric bacterial panel to routine culture methods for detection of Campylobacter, enterohemorrhagic Escherichia coli (O157), Salmonella, and Shigella isolates in preserved stool specimens. J Clin Microbiol (2014) 0.91
The role of complement opsonization in interactions between F. tularensis subsp. novicida and human neutrophils. Microbes Infect (2009) 0.90
Light microscopy, culture, molecular, and serologic methods for detection of herpes simplex virus. J Clin Microbiol (2013) 0.90
Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis. J Innate Immun (2012) 0.88
The Francisella tularensis migR, trmE, and cphA genes contribute to F. tularensis pathogenicity island gene regulation and intracellular growth by modulation of the stress alarmone ppGpp. Infect Immun (2013) 0.88
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun (2012) 0.86
Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun (2014) 0.84
Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice. Pain (2016) 0.83
Stage-specific pathways of Leishmania infantum chagasi entry and phagosome maturation in macrophages. PLoS One (2011) 0.83
MHC Class II levels and intracellular localization in human dendritic cells are regulated by calmodulin kinase II. J Leukoc Biol (2007) 0.83
Multicenter evaluation of the Verigene Clostridium difficile nucleic acid assay. J Clin Microbiol (2013) 0.83
Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigs. Am J Vet Res (2004) 0.82
Editorial: Leukocytes in tularemia--so many cells, so little time. J Leukoc Biol (2013) 0.79
Biofilm formation by Salmonella enterica serovar Typhimurium and Escherichia coli on epithelial cells following mixed inoculations. Infect Immun (2005) 0.79
Spatially tracking (13) C-labelled substrate (bicarbonate) accumulation in microbial communities using laser ablation isotope ratio mass spectrometry. Environ Microbiol Rep (2014) 0.79
A high-throughput genetic system for assessing the inhibition of proteins: identification of antibiotic resistance and virulence targets and their cognate inhibitors in Salmonella. Anal Biochem (2002) 0.78
Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis. J Innate Immun (2016) 0.77
Genome Sequence of the Thermophilic Cyanobacterium Thermosynechococcus sp. Strain NK55a. Genome Announc (2014) 0.75
Writing a first grant proposal. Nat Immunol (2012) 0.75