Published in Cancer Biol Ther on November 11, 2005
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem (2010) 2.49
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays (2007) 2.40
Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One (2012) 1.87
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res (2008) 1.64
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol (2009) 1.44
Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia (2011) 1.39
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
Krüppel-like factors in cancer. Nat Rev Cancer (2013) 1.32
Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res (2009) 1.31
Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim Biophys Acta (2008) 1.21
SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem (2008) 1.18
Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus. Gastroenterology (2010) 1.13
A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res (2014) 1.10
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. Mol Cancer (2007) 1.09
Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem (2008) 1.03
Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol (2011) 1.02
Regulation of EMT by KLF4 in gastrointestinal cancer. Curr Cancer Drug Targets (2013) 1.02
KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol Ther (2010) 1.02
Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology (2010) 0.99
Kruppel-like factor 4 is a novel mediator of selenium in growth inhibition. Mol Cancer Res (2008) 0.98
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer (2013) 0.96
BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest (2015) 0.96
Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. Respir Res (2011) 0.95
Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells. Biochem J (2011) 0.94
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation. Mol Cell Biol (2007) 0.94
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking. Nat Commun (2013) 0.91
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res (2011) 0.90
Krüppel-like factors in cancer progression: three fingers on the steering wheel. Oncotarget (2014) 0.90
A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition. PLoS One (2011) 0.88
Chronic alcohol ingestion in rats decreases Krüppel-like factor 4 expression and intracellular zinc in the lung. Alcohol Clin Exp Res (2012) 0.87
Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer. Oncol Lett (2012) 0.87
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle (2012) 0.86
Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol (2009) 0.85
Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma. Am J Physiol Gastrointest Liver Physiol (2012) 0.85
Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival. Neoplasia (2013) 0.84
Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate. Hum Mol Genet (2015) 0.82
Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways. Neoplasia (2014) 0.82
Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One (2012) 0.81
FBW7-mediated ubiquitination and degradation of KLF5. World J Biol Chem (2014) 0.80
Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. PLoS One (2013) 0.80
Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget (2016) 0.79
Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Semin Cancer Biol (2015) 0.79
Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget (2015) 0.79
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Sci Rep (2016) 0.79
KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions. Cancer Biol Ther (2016) 0.79
Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis. Invest Ophthalmol Vis Sci (2015) 0.79
Krüppel-like factors 4 and 5: unity in diversity. Curr Genomics (2009) 0.78
MicroRNA-10b regulates epithelial-mesenchymal transition by modulating KLF4/Notch1/E-cadherin in cisplatin-resistant nasopharyngeal carcinoma cells. Am J Cancer Res (2016) 0.77
Expression of Krűppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan. Virchows Arch (2011) 0.76
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS One (2015) 0.76
Inhibition of MiR-92a May Protect Endothelial Cells After Acute Myocardial Infarction in Rats: Role of KLF2/4. Med Sci Monit (2016) 0.75
Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Oncotarget (2016) 0.75
Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol (2010) 0.75
Prognostic significance of KLF4 expression in gastric cancer. Oncol Lett (2016) 0.75
NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway. Cancer Biol Ther (2016) 0.75
Krüppel-like factor 4 (KLF4): What we currently know. Gene (2017) 0.75
Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas. Invest Ophthalmol Vis Sci (2017) 0.75
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology (2005) 2.53
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival. Breast Cancer Res Treat (2011) 2.23
Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell (2011) 2.10
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63
Krüppel-like factors in cancer. Nat Rev Cancer (2013) 1.32
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J Biol Chem (2007) 1.29
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology (2010) 1.29
Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res (2006) 1.28
Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J (2006) 1.18
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes Dev (2005) 1.17
Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus. Gastroenterology (2010) 1.13
Molecular cloning and promoter analysis of downregulated in adenoma (DRA). Am J Physiol Gastrointest Liver Physiol (2007) 1.07
Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem (2008) 1.03
Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells. Am J Physiol Gastrointest Liver Physiol (2007) 1.02
Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology (2010) 0.99
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicol Appl Pharmacol (2008) 0.95
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine. Neoplasia (2008) 0.91
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res (2011) 0.90
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle (2012) 0.86
Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival. Neoplasia (2013) 0.84
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake. Am J Physiol Gastrointest Liver Physiol (2004) 0.84
Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells. Dev Biol (2008) 0.83
Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. Mech Dev (2009) 0.81
Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One (2012) 0.81
Villin-marked gastric progenitor cells: conveyors or purveyors of precancerous change? Gastroenterology (2012) 0.75
CPR-not-indicated and futility. Ann Intern Med (1996) 0.75