Published in Bioessays on June 01, 2007
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell (2014) 2.23
Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One (2012) 1.87
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim Biophys Sin (Shanghai) (2008) 1.76
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology (2011) 1.67
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol (2011) 1.67
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology (2007) 1.58
KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. J Clin Invest (2014) 1.54
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48
Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res (2008) 1.46
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res (2009) 1.29
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol (2009) 1.22
Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res (2013) 1.21
SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem (2008) 1.18
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15
Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Dev Biol (2010) 1.14
Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection. Gastroenterology (2008) 1.11
Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology (2012) 1.10
Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology (2011) 1.10
The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression. Reprod Biol Endocrinol (2008) 1.06
KLF4 regulation in intestinal epithelial cell maturation. Exp Cell Res (2008) 1.06
Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.06
Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem (2008) 1.03
Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable. Oncogene (2009) 1.03
Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair. Gastroenterology (2010) 1.03
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. Mol Cancer (2010) 1.03
Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol (2011) 1.02
Cross-species de novo identification of cis-regulatory modules with GibbsModule: application to gene regulation in embryonic stem cells. Genome Res (2008) 1.02
The Pathobiology of Krüppel-like Factors in Colorectal Cancer. Curr Colorectal Cancer Rep (2008) 1.02
Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology (2010) 0.99
Genomic landscape of human papillomavirus-associated cancers. Clin Cancer Res (2015) 0.99
MiR-7 promotes epithelial cell transformation by targeting the tumor suppressor KLF4. PLoS One (2014) 0.98
Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. J Biol Chem (2013) 0.97
Modeling co-expression across species for complex traits: insights to the difference of human and mouse embryonic stem cells. PLoS Comput Biol (2010) 0.96
Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis. Mol Cell (2012) 0.95
Stem cells in colon cancer. A new era in cancer theory begins. Int J Colorectal Dis (2010) 0.95
MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients. PLoS One (2011) 0.95
Krüppel-like factors: three fingers in control. Hum Genomics (2010) 0.95
Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci (2011) 0.94
Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Mol Cancer Ther (2009) 0.93
A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4. J Biol Chem (2010) 0.92
Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pulmonary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells. Int J Cancer (2013) 0.91
Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.91
Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development (2010) 0.91
Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet (2013) 0.91
Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol Cell Biol (2011) 0.91
Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Dev Biol (2011) 0.91
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking. Nat Commun (2013) 0.91
The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein. J Biol Chem (2011) 0.91
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res (2011) 0.90
Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One (2013) 0.90
Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics (2013) 0.89
Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen. Biol Reprod (2011) 0.89
Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation. FASEB J (2011) 0.87
Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer. Oncol Lett (2012) 0.87
Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon. Dev Biol (2014) 0.87
Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation. Am J Physiol Gastrointest Liver Physiol (2014) 0.86
Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. J Biol Chem (2012) 0.86
Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response. Inflamm Bowel Dis (2014) 0.86
Regulation of corneal epithelial barrier function by Kruppel-like transcription factor 4. Invest Ophthalmol Vis Sci (2011) 0.86
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle (2012) 0.86
Restoring KLF5 in esophageal squamous cell cancer cells activates the JNK pathway leading to apoptosis and reduced cell survival. Neoplasia (2013) 0.84
A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α). J Biol Chem (2014) 0.84
Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. Cell Death Dis (2015) 0.83
Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells. Stem Cell Res (2014) 0.83
Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts. Am J Cancer Res (2011) 0.82
Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer. World J Surg Oncol (2011) 0.81
Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice. Stem Cell Reports (2016) 0.81
Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One (2012) 0.81
Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite. Diabetes (2010) 0.81
Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. PLoS One (2013) 0.80
Retinoic acid receptor α mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells. J Biol Chem (2012) 0.80
IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J (2015) 0.80
KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Sci Rep (2016) 0.79
Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas. PLoS One (2012) 0.79
KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions. Cancer Biol Ther (2016) 0.79
Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis. Invest Ophthalmol Vis Sci (2015) 0.79
KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes. Genome Biol Evol (2015) 0.78
Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma. In Vivo (2009) 0.78
High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer. Future Oncol (2012) 0.78
Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis. Stem Cells Int (2015) 0.77
ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer. Mol Cancer Ther (2015) 0.77
Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells. Immunology (2008) 0.77
KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial-Mesenchymal Transition. Invest Ophthalmol Vis Sci (2017) 0.76
Regulatable in vivo biotinylation expression system in mouse embryonic stem cells. PLoS One (2013) 0.76
The expression and role of krüppel-like factor 4 in psoriasis. Ann Dermatol (2014) 0.76
Pluripotent states of human embryonic stem cells. Cell Reprogram (2014) 0.76
Small molecule and RNAi induced phenotype transition of expanded and primary colonic epithelial cells. Sci Rep (2015) 0.76
Epigallocatechin-3-gallate regulates the expression of Kruppel-like factor 4 through myocyte enhancer factor 2A. Cell Stress Chaperones (2013) 0.75
Klf5 Mediates Odontoblastic Differentiation through Regulating Dentin-Specific Extracellular Matrix Gene Expression during Mouse Tooth Development. Sci Rep (2017) 0.75
Transgenic and gene knockout mice in gastric cancer research. Oncotarget (2016) 0.75
Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice. Int J Biol Sci (2015) 0.75
Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells. Biol Open (2016) 0.75
Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages. Am J Transl Res (2016) 0.75
Klf2 contributes to the stemness and self-renewal of human bone marrow stromal cells. Cytotechnology (2014) 0.75
Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports (2016) 0.75
The upregulation of zinc finger protein 670 and prostaglandin D2 synthase in proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol (2015) 0.75
Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt. Stem Cell Transl Investig (2015) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem (1996) 5.52
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Krüppel-like factors: three fingers in many pies. J Biol Chem (2001) 5.05
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol (2005) 4.29
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer (2006) 4.14
New genes involved in cancer identified by retroviral tagging. Nat Genet (2002) 4.14
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res (1999) 3.68
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab (2005) 3.49
The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem (1996) 3.30
The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A (1993) 3.25
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem (2000) 3.02
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene (2004) 2.96
Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res (2000) 2.80
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res (2005) 2.73
Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle. J Biol Chem (2001) 2.71
Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res (2005) 2.67
Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF. Cell Growth Differ (1999) 2.64
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med (2002) 2.61
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology (2005) 2.53
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene (2005) 2.50
Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res (2000) 2.34
Cell-cycle inhibitors: three families united by a common cause. Gene (2000) 2.28
Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo. Nature (1985) 2.25
Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem (2002) 2.19
Prevalent mutations in prostate cancer. J Cell Biochem (2006) 2.12
Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol (2003) 2.11
Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene (2003) 2.11
Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. J Biol Chem (2001) 2.01
Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem Biophys Res Commun (2003) 2.01
Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Mol Cell Biol (2001) 1.98
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis (2005) 1.94
A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res (1999) 1.85
Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. Am J Physiol Gastrointest Liver Physiol (2000) 1.83
Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res (2005) 1.82
Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem (2003) 1.76
Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Dev Biol (1984) 1.76
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene (2001) 1.74
Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene (2004) 1.70
Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett (2000) 1.70
KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther (2005) 1.67
Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development (2003) 1.64
Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res (2002) 1.64
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene (2005) 1.64
Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis. FEBS Lett (1997) 1.60
A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene (2002) 1.55
Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem (2004) 1.53
Genetic events and the role of TGF beta in epithelial tumour progression. J Pathol (1999) 1.52
Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4). Nucleic Acids Res (1999) 1.51
Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Dev Dyn (2000) 1.50
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate (2003) 1.47
Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. Oncogene (2006) 1.45
KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer (2006) 1.44
Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res (2006) 1.43
Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene (2005) 1.40
KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia. Cancer Biol Ther (2005) 1.38
All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5. FEBS Lett (2004) 1.35
Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. World J Gastroenterol (2002) 1.34
Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett (2005) 1.31
Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells. Circ Res (1999) 1.31
Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol (2003) 1.29
Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res (2006) 1.28
Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. J Biol Chem (2003) 1.27
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J Cell Sci (2006) 1.25
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Clin Cancer Res (2006) 1.24
Mouse Sprr locus: a tandem array of coordinately regulated genes. Mamm Genome (2003) 1.24
Altered expression of the KLF4 in colorectal cancers. Pathol Res Pract (2006) 1.23
Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB J (2006) 1.18
Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells. J Biol Chem (2002) 1.15
A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. Hum Genet (2001) 1.04
Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5. J Biol Chem (2006) 1.02
Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain. J Biol Chem (2003) 1.02
Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene Expr (2006) 0.98
Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur J Cell Biol (2002) 0.98
Molecular analysis of Krüppel, a segmentation gene of Drosophila melanogaster. Cold Spring Harb Symp Quant Biol (1985) 0.96
Transcriptional regulation of smooth muscle phenotypic modulation. Ann N Y Acad Sci (2000) 0.87
Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2. Cardiology (2003) 0.87
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
Primary chemoprevention of familial adenomatous polyposis with sulindac. N Engl J Med (2002) 3.16
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene (2004) 2.96
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res (2005) 2.73
Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology (2008) 2.31
Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem (2002) 2.19
Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol (2003) 2.11
Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene (2003) 2.11
Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96
Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem (2003) 1.76
Krüppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest (2015) 1.72
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71
Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras. Oncogene (2004) 1.70
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst (2007) 1.65
Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res (2002) 1.64
Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology (2012) 1.64
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology (2007) 1.58
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology (2009) 1.56
Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res (2007) 1.47
Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res (2008) 1.46
Near IR heptamethine cyanine dye-mediated cancer imaging. Clin Cancer Res (2010) 1.44
Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene (2005) 1.40
Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting. Genet Med (2011) 1.37
All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5. FEBS Lett (2004) 1.35
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation. FEBS Lett (2005) 1.31
Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. Mol Cancer Res (2008) 1.30
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res (2009) 1.29
Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol (2003) 1.29
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J Biol Chem (2007) 1.29
Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells. Nucleic Acids Res (2006) 1.28
Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem (2004) 1.22
p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells. Cancer Res (2007) 1.20
SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem (2008) 1.18
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15
Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Dev Biol (2010) 1.14
Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection. Gastroenterology (2008) 1.11
Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology (2011) 1.10
KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol (2008) 1.08
Expression of the tumor suppressor Krüppel-like factor 4 as a prognostic predictor for colon cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.06
The Role of Inflammation in the Pathogenesis of Colorectal Cancer. Curr Colorectal Cancer Rep (2009) 1.04
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations. Mol Cancer (2010) 1.03
Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair. Gastroenterology (2010) 1.03
Kruppel-like factors regulate the Lama1 gene encoding the laminin alpha1 chain. J Biol Chem (2003) 1.02
Protein inhibitor of activated STAT1 interacts with and up-regulates activities of the pro-proliferative transcription factor Krüppel-like factor 5. J Biol Chem (2006) 1.02
The Pathobiology of Krüppel-like Factors in Colorectal Cancer. Curr Colorectal Cancer Rep (2008) 1.02
Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. Gastroenterology (2004) 1.01
Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis. Gene Expr (2006) 0.98
Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo. J Cell Biochem (2012) 0.98
Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. Biochim Biophys Acta (2007) 0.97
Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5. J Biol Chem (2013) 0.97
The challenges facing GI investigators today and what (more) the GI societies can do to help. Gastroenterology (2007) 0.97
Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer (2013) 0.96
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther (2011) 0.94
Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Mol Cancer Ther (2009) 0.93
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A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4. J Biol Chem (2010) 0.92
The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein. J Biol Chem (2011) 0.91
Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives. Pharmacogenomics (2007) 0.90
Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One (2013) 0.90
Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. Gastroenterology (2011) 0.90
Genetics of colorectal cancer. MedGenMed (2004) 0.87
Molecular Genetics of Colorectal Cancer: An Overview. Curr Colorectal Cancer Rep (2006) 0.87
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev (2005) 0.87
Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response. Inflamm Bowel Dis (2014) 0.86
Genetic polymorphisms of human flavin monooxygenase 3 in sulindac-mediated primary chemoprevention of familial adenomatous polyposis. Clin Cancer Res (2004) 0.85
Genetic and Chemical Models of Colorectal Cancer in Mice. Curr Colorectal Cancer Rep (2010) 0.85
Mitotic Origins of Chromosomal Instability in Colorectal Cancer. Curr Colorectal Cancer Rep (2007) 0.84
A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α). J Biol Chem (2014) 0.84
Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem (2013) 0.83
Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation. J Gastrointest Surg (2003) 0.83
Colon cancer: an update and future directions. Gastroenterology (2010) 0.82