Published in Diabetes on January 01, 2006
The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Clin Exp Immunol (2010) 3.17
Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol (2010) 2.26
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One (2011) 2.18
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol (2013) 1.65
Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. PLoS One (2010) 1.43
RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol (2008) 1.41
The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes. Cold Spring Harb Perspect Med (2012) 1.10
Different subsets of natural killer T cells may vary in their roles in health and disease. Immunology (2014) 1.01
Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med (2011) 0.97
Current and future immunomodulation strategies to restore tolerance in autoimmune diseases. Cold Spring Harb Perspect Biol (2012) 0.91
Toll-Like Receptor Activation in Immunity vs. Tolerance in Autoimmune Diabetes. Front Immunol (2014) 0.90
The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS One (2009) 0.90
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: immune therapies of type 1 diabetes: new opportunities based on the hygiene hypothesis. Clin Exp Immunol (2010) 0.87
Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes. J Cell Mol Med (2014) 0.87
OM85-BV induced the productions of IL-1β, IL-6, and TNF-α via TLR4- and TLR2-mediated ERK1/2/NF-κB pathway in RAW264.7 cells. J Interferon Cytokine Res (2014) 0.86
Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nat Rev Endocrinol (2010) 0.85
NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation. Curr Immunol Rev (2012) 0.85
Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art. Multidiscip Respir Med (2013) 0.83
Autoimmunity and inflammation: murine models and translational studies. Mamm Genome (2011) 0.82
Customizing laboratory mice by modifying gut microbiota and host immunity in an early "window of opportunity". Gut Microbes (2013) 0.82
Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS One (2013) 0.82
Neonatal Gastrointestinal and Respiratory Microbiome in Cystic Fibrosis: Potential Interactions and Implications for Systemic Health. Clin Ther (2016) 0.78
May we strengthen the human natural defenses with bacterial lysates? World Allergy Organ J (2010) 0.78
Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes. PLoS One (2015) 0.77
Helminth infection and type 1 diabetes. Rev Diabet Stud (2012) 0.76
Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study. PLoS One (2017) 0.75
OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice. Clin Vaccine Immunol (2011) 0.75
Antibiotics, gut microbiota, environment in early life and type 1 diabetes. Pharmacol Res (2017) 0.75
Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice. J Diabetes Res (2015) 0.75
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 10.16
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med (2003) 4.40
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med (2010) 2.21
Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol (2002) 2.17
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes (2005) 2.10
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes (2008) 2.04
Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study. Blood (2005) 1.99
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes (2007) 1.98
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A (2007) 1.90
Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity (2005) 1.86
Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood (2004) 1.71
Treatment with granulocyte colony-stimulating factor prevents diabetes in NOD mice by recruiting plasmacytoid dendritic cells and functional CD4(+)CD25(+) regulatory T-cells. Diabetes (2005) 1.44
Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem (2004) 1.44
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. J Clin Invest (2015) 1.43
Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice. PLoS One (2010) 1.43
Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. J Immunol (2005) 1.38
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood (2009) 1.37
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells. Eur J Immunol (2003) 1.35
Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2004) 1.32
Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation (2006) 1.31
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes (2013) 1.30
The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J Immunol (2002) 1.28
Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance. J Immunol (2002) 1.26
Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol (2011) 1.25
Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity (2006) 1.22
Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help. Eur J Pharmacol (2007) 1.21
Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies. Vaccine (2002) 1.20
Differential effects of IL-27 on human B cell subsets. J Immunol (2006) 1.18
Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases. Proc Natl Acad Sci U S A (2003) 1.14
Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. Am J Pathol (2005) 1.13
The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes. Cold Spring Harb Perspect Med (2012) 1.10
Transforming growth factor-beta and T-cell-mediated immunoregulation in the control of autoimmune diabetes. Immunol Rev (2006) 1.09
Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease. Clin Immunol (2005) 1.08
Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology (2012) 1.08
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes. Diabetes (2010) 1.07
G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J Immunol (2002) 1.06
TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood (2007) 1.04
Basophils: new players in the cytokine network. Eur Cytokine Netw (2010) 0.99
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice. Ann N Y Acad Sci (2008) 0.98
ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes. Diabetes (2012) 0.97
Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes. J Clin Pharmacol (2010) 0.96
Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med (2011) 0.96
Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors. Blood (2008) 0.95
Long-term reversal of established autoimmunity upon transient blockade of the LFA-1/intercellular adhesion molecule-1 pathway. J Immunol (2002) 0.95
A view on beta cell transplantation in diabetes. Ann N Y Acad Sci (2002) 0.94
Antitumour effect of OM-174 and cyclophosphamide on murine B16 melanoma in different experimental conditions. Int Immunopharmacol (2005) 0.94
HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10. Retrovirology (2013) 0.93
The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma. J Immunol (2010) 0.92
Anti-CD3 clinical trials in type 1 diabetes mellitus. Clin Immunol (2013) 0.92
Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats. Eur J Pharmacol (2004) 0.91
The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis. J Immunol (2007) 0.91
Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target. PLoS One (2009) 0.90
Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse. Int Rev Immunol (2005) 0.90
Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. Transplantation (2005) 0.90
The elusive case for a role of mimicry in autoimmune diseases. Mol Immunol (2004) 0.90
Calcium dobesilate in the treatment of diabetic retinopathy. Treat Endocrinol (2005) 0.89
Toward cell-based therapy of type I diabetes. Trends Immunol (2008) 0.89
Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms. Eur J Immunol (2011) 0.89
A historical view from thirty eventful years of immunotherapy in autoimmune diabetes. Semin Immunol (2011) 0.87
New generation CD3 monoclonal antibodies: are we ready to have them back in clinical transplantation? Curr Opin Organ Transplant (2010) 0.87
Weaned from the needle. Nat Med (2006) 0.86
Adaptive human regulatory T cells: myth or reality? J Clin Invest (2006) 0.85
FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis. Nephrol Dial Transplant (2009) 0.84
Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients. Diabetes Metab Res Rev (2002) 0.83
Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells. J Biol Chem (2011) 0.83
Immune response to human embryonic stem cell-derived cardiac progenitors and adipose-derived stromal cells. J Cell Mol Med (2012) 0.83
G-CSF treatment prevents cyclophosphamide acceleration of autoimmune diabetes in the NOD mouse. J Autoimmun (2005) 0.83
Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One (2013) 0.82
Increased incidence of inflammatory bowel disease: the price of the decline of infectious burden? Curr Opin Gastroenterol (2004) 0.82
Genetic control of hepatitis A severity and susceptibility to allergy. J Clin Invest (2011) 0.82
Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats. Eur J Pharmacol (2005) 0.82
Proinsulin: a unique autoantigen triggering autoimmune diabetes. J Clin Invest (2006) 0.81
Diabetes: type 1 diabetes mellitus--a door opening to a real therapy? Nat Rev Endocrinol (2011) 0.81
A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route. Vaccine (2007) 0.81
The adjuvant OM-174 induces both the migration and maturation of murine dendritic cells in vivo. Vaccine (2003) 0.81