Published in Med Res Rev on May 01, 2006
An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell (2007) 2.75
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol (2009) 1.85
Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket. Curr Med Chem (2008) 1.84
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (2008) 1.52
Pharmacological targeting of the Hsp70 chaperone. Curr Top Med Chem (2009) 1.51
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity. J Org Chem (2008) 1.49
Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J Biol Chem (2009) 1.45
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol (2009) 1.43
Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents. J Med Chem (2011) 1.36
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat (2009) 1.27
Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. Nat Struct Mol Biol (2009) 1.22
Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN Neuro (2010) 1.21
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci U S A (2012) 1.11
Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity. ACS Med Chem Lett (2010) 1.10
Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J Med Chem (2008) 1.07
Development of a Grp94 inhibitor. J Am Chem Soc (2012) 1.06
A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem (2010) 1.04
(-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. Mol Pharm (2009) 1.03
Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases. Curr Top Med Chem (2009) 1.02
3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition. ACS Med Chem Lett (2012) 1.01
Natural product inhibitors of Hsp90: potential leads for drug discovery. Mini Rev Med Chem (2009) 0.98
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem (2008) 0.96
HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways. Inflamm Res (2012) 0.95
Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. Cell Mol Immunol (2012) 0.95
Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget (2013) 0.93
A novel HSP90 modulator with selective activity against thyroid cancers in vitro. Surgery (2009) 0.93
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma. Proc Natl Acad Sci U S A (2009) 0.92
Identification of a new scaffold for hsp90 C-terminal inhibition. ACS Med Chem Lett (2013) 0.89
Dimeric approaches to anti-cancer chemotherapeutics. Anticancer Agents Med Chem (2008) 0.87
Measurement of nanomolar dissociation constants by titration calorimetry and thermal shift assay - radicicol binding to Hsp90 and ethoxzolamide binding to CAII. Int J Mol Sci (2009) 0.87
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer. Invest New Drugs (2010) 0.86
3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues. ACS Med Chem Lett (2012) 0.86
Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues. Bioorg Med Chem Lett (2010) 0.86
Novobiocin analogues with second-generation noviose surrogates. Bioorg Med Chem Lett (2012) 0.85
Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors. Medchemcomm (2014) 0.84
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors. Eur J Med Chem (2014) 0.84
Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. J Org Chem (2009) 0.83
Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. J Biol Chem (2015) 0.82
FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer (2014) 0.82
Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines. Bioorg Med Chem Lett (2014) 0.81
Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opin Ther Targets (2014) 0.81
Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PLoS One (2014) 0.81
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. ASN Neuro (2012) 0.81
Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitors. ACS Med Chem Lett (2014) 0.80
Four Classes of Structurally Unusual Peptides from Two Marine-Derived Fungi: Structures and Bioactivities. Tetrahedron (2007) 0.80
Regulation and function of the human HSP90AA1 gene. Gene (2015) 0.80
Development of Noviomimetics as C-Terminal Hsp90 Inhibitors. ACS Med Chem Lett (2015) 0.80
Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells. Bioorg Med Chem Lett (2007) 0.78
A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma. Virology (2007) 0.78
Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. Bioorg Med Chem Lett (2009) 0.77
Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1. Br J Pharmacol (2014) 0.76
Molecular docking and pharmacophore studies of heterocyclic compounds as Heat shock protein 90 (Hsp90) Inhibitors. Bioinformation (2016) 0.75
Re-examining HSPC1 inhibitors. Cell Stress Chaperones (2017) 0.75
HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer. PLoS One (2014) 0.75
Heat shock response and insulin-associated neurodegeneration. Trends Pharmacol Sci (2011) 0.75
Synthesis of a versatile metacyclophane macrolactam. Tetrahedron Lett (2008) 0.75