Published in Curr Top Med Chem on January 01, 2009
Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem (2010) 2.21
The HSP70 family and cancer. Carcinogenesis (2013) 2.06
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov (2011) 1.71
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface. Proc Natl Acad Sci U S A (2011) 1.47
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
Natural products as chemical probes. ACS Chem Biol (2010) 1.29
Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol (2010) 1.28
Role of redox signaling in neuroinflammation and neurodegenerative diseases. Biomed Res Int (2013) 1.25
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med (2012) 1.18
Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK). J Biol Chem (2010) 1.15
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chem Biol (2013) 1.12
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol (2011) 1.11
Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Am J Physiol Endocrinol Metab (2011) 1.11
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol (2012) 1.10
Hsp70 in cancer: back to the future. Oncogene (2014) 1.03
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proc Natl Acad Sci U S A (2011) 1.02
Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci (2013) 1.00
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. J Cell Biol (2015) 0.98
High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer. J Biomol Screen (2010) 0.98
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. J Med Chem (2014) 0.97
Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations. PLoS Comput Biol (2012) 0.97
Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones. Front Mol Biosci (2015) 0.95
Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress Chaperones (2011) 0.92
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Med Chem (2011) 0.92
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. ACS Chem Biol (2014) 0.92
Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. ACS Chem Biol (2013) 0.91
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. PLoS One (2014) 0.90
Protein chaperones: a composition of matter review (2008 - 2013). Expert Opin Ther Pat (2014) 0.86
Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity. Oncotarget (2014) 0.86
Proteostasis: a new therapeutic paradigm for pulmonary disease. Proc Am Thorac Soc (2011) 0.86
Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. J Biol Chem (2011) 0.86
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry (2011) 0.85
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition. Cancer Biol Ther (2013) 0.81
Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy. Expert Rev Proteomics (2010) 0.81
Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein. PLoS One (2015) 0.80
DnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70. PLoS One (2015) 0.79
An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40. Nucleic Acid Ther (2015) 0.78
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer. BMC Cancer (2012) 0.78
The role of HTS in drug discovery at the University of Michigan. Comb Chem High Throughput Screen (2014) 0.78
Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks. Front Bioeng Biotechnol (2015) 0.78
Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Mol Biosyst (2012) 0.77
Proteome interrogation using nanoprobes to identify targets of a cancer-killing molecule. J Am Chem Soc (2011) 0.77
Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival. Prog Retin Eye Res (2016) 0.76
Luteal serum BDNF and HSP70 levels in women with premenstrual dysphoric disorder. Eur Arch Psychiatry Clin Neurosci (2013) 0.76
Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. PLoS Comput Biol (2013) 0.76
A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens. Sci Rep (2015) 0.75
Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation. Am J Physiol Cell Physiol (2016) 0.75
The remarkable multivalency of the Hsp70 chaperones. Cell Stress Chaperones (2017) 0.75
Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Biomol NMR Assign (2016) 0.75
Aptamer-Enabled Manipulation of the Hsp70 Chaperone System Suggests a Novel Strategy for Targeted Ubiquitination. Nucleic Acid Ther (2015) 0.75
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep (2016) 0.75
Therapeutic Strategies for Restoring Tau Homeostasis. Cold Spring Harb Perspect Med (2017) 0.75
HSP90 and the chaperoning of cancer. Nat Rev Cancer (2005) 11.98
Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci (2005) 9.75
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature (2007) 9.12
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci (2003) 8.44
Molecular chaperones and protein quality control. Cell (2006) 7.74
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature (2003) 7.69
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell (2000) 7.25
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (2001) 6.15
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol (2001) 6.10
Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK. Proc Natl Acad Sci U S A (1991) 5.96
Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem (2001) 5.74
Folding proteins in fatal ways. Nature (2003) 5.58
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell (1998) 5.52
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol (2001) 5.36
Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 5.22
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell (2006) 5.01
Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci (2005) 5.00
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol (1999) 4.98
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet (1999) 4.93
GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res (2007) 4.73
GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J (1997) 4.68
Therapeutic approaches to protein-misfolding diseases. Nature (2003) 4.57
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53
Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J (1997) 4.28
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem (2001) 4.14
Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function. Cell Stress Chaperones (1998) 3.94
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci U S A (2000) 3.82
Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann N Y Acad Sci (2007) 3.74
The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell Mol Life Sci (2006) 3.62
Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci U S A (1999) 3.54
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science (1997) 3.31
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science (2001) 3.27
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr Biol (2001) 3.21
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins. Nat Struct Mol Biol (2009) 3.21
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Nat Med (2005) 3.19
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet (2004) 3.12
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem (1996) 3.00
More than folding: localized functions of cytosolic chaperones. Trends Biochem Sci (2003) 2.95
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med (2004) 2.86
The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication. J Biol Chem (1994) 2.85
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J (2009) 2.83
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res (2008) 2.81
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci U S A (2009) 2.77
Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc Natl Acad Sci U S A (1998) 2.66
Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. J Biol Chem (1998) 2.63
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. J Biol Chem (2004) 2.62
Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci (2002) 2.58
From the cradle to the grave: molecular chaperones that may choose between folding and degradation. EMBO Rep (2001) 2.55
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell (2008) 2.49
Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J (2006) 2.45
Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem (2004) 2.45
Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker. Mol Cell (2007) 2.39
Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast. Mol Biol Cell (2001) 2.34
A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates. EMBO J (1996) 2.33
Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry (2008) 2.18
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum Mol Genet (2000) 2.17
Roles of molecular chaperones in protein misfolding diseases. Semin Cell Dev Biol (2004) 2.14
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (2004) 2.14
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet (2001) 2.13
Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone. Proc Natl Acad Sci U S A (1998) 2.10
Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Protein Sci (2005) 2.10
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. J Biol Chem (2002) 2.04
Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. Med Res Rev (2006) 2.02
Chaperones in control of protein disaggregation. EMBO J (2008) 2.01
Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach. Hum Mol Genet (2004) 2.00
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci (2006) 1.98
Heat shock protein 90 as a drug target: some like it hot. Clin Cancer Res (2009) 1.96
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol Cell (2005) 1.94
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin. Cancer Res (2005) 1.93
Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets (2009) 1.91
Allosteric regulation of Hsp70 chaperones by a proline switch. Mol Cell (2006) 1.88
The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Mol Microbiol (2007) 1.87
Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. J Biol Chem (2006) 1.86
Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast. Mol Biol Cell (2004) 1.86
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol Cell Biol (2008) 1.82
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res (2000) 1.81
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Curr Top Med Chem (2006) 1.77
Multiple roles of auxilin and hsc70 in clathrin-mediated endocytosis. Traffic (2007) 1.75
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem (2001) 1.75
The hsp70 chaperone DnaK is a secondary amide peptide bond cis-trans isomerase. Nat Struct Biol (2002) 1.72
The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry (2001) 1.70
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res (2000) 1.70
Isolation and characterization of dnaJ null mutants of Escherichia coli. J Bacteriol (1990) 1.70
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Interaction between heat shock proteins and antimicrobial peptides. Biochemistry (2000) 1.66
Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A (2008) 1.66
High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK. Anal Biochem (2007) 1.65
The glycine-phenylalanine-rich region determines the specificity of the yeast Hsp40 Sis1. Mol Cell Biol (1999) 1.65
Chaperoning of glucocorticoid receptors. Handb Exp Pharmacol (2006) 1.62
Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci U S A (2007) 1.61
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res (2006) 1.60
Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science (1992) 1.59
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol (2005) 1.53
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. J Biol Chem (2004) 1.51
Hsp90: a novel target for the disruption of multiple signaling cascades. Curr Cancer Drug Targets (2007) 1.51
GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism. Biochemistry (1997) 1.48
BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
Synthetic multivalent ligands as probes of signal transduction. Angew Chem Int Ed Engl (2006) 3.29
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci U S A (2009) 2.77
Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem (2010) 2.21
Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell (2003) 2.20
Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci (2009) 2.05
Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism. Chem Biol (2011) 1.89
Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. J Biol Chem (2006) 1.86
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol Neurodegener (2010) 1.68
High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK. Anal Biochem (2007) 1.65
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol (2006) 1.65
Allostery in the Hsp70 chaperone proteins. Top Curr Chem (2013) 1.52
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J Mol Biol (2011) 1.49
Control of multivalent interactions by binding epitope density. J Am Chem Soc (2002) 1.46
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy (2012) 1.44
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol (2012) 1.37
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell (2011) 1.37
Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des (2007) 1.36
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem (2010) 1.29
Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol (2010) 1.28
Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem (2009) 1.22
Fine-tuning multiprotein complexes using small molecules. ACS Chem Biol (2012) 1.21
Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions. Chem Biol Drug Des (2013) 1.21
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med (2012) 1.18
Identification of dihydropyridines that reduce cellular tau levels. Chem Commun (Camb) (2010) 1.17
Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK). J Biol Chem (2010) 1.15
Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem (2007) 1.10
Insight into amyloid structure using chemical probes. Chem Biol Drug Des (2011) 1.10
A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers (2008) 1.10
Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol (2012) 1.10
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol (2014) 1.09
Identification of small molecules that modify the protein folding activity of heat shock protein 70. Anal Biochem (2007) 1.08
Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J (2012) 1.07
Hsc70 rapidly engages tau after microtubule destabilization. J Biol Chem (2010) 1.06
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry (2013) 1.03
Synthesis and applications of end-labeled neoglycopolymers. Org Lett (2002) 1.03
CSAR data set release 2012: ligands, affinities, complexes, and docking decoys. J Chem Inf Model (2013) 1.02
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem (2013) 1.01
Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci (2013) 1.00
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett (2013) 1.00
Tetradehydrohalicyclamine A and 22-hydroxyhalicyclamine A, new cytotoxic bis-piperidine alkaloids from a marine sponge Amphimedon sp. J Nat Prod (2004) 1.00
A small molecule-directed approach to control protein localization and function. Yeast (2008) 0.98
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One (2012) 0.98
High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer. J Biomol Screen (2010) 0.98
The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry (2013) 0.95
Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chem Biol (2012) 0.94
Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress Chaperones (2011) 0.92
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Med Chem (2011) 0.92
FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Proc Natl Acad Sci U S A (2009) 0.91
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Bioorg Med Chem Lett (2009) 0.90
Conserved amplification of chemotactic responses through chemoreceptor interactions. J Bacteriol (2002) 0.90
Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines. Org Lett (2009) 0.90
Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. Bioorg Med Chem Lett (2007) 0.90
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. J Biol Chem (2012) 0.90
Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod (2007) 0.88
The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation. J Mol Biol (2012) 0.87
The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. J Biol Chem (2013) 0.86
Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. J Biol Chem (2011) 0.86
Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease. Proteins (2009) 0.85
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry (2011) 0.85
Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein. Mol Biosyst (2008) 0.84
Bicinchoninic acid (BCA) assay in low volume. Anal Biochem (2010) 0.84
Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. ACS Chem Biol (2012) 0.83
Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization. Nat Protoc (2010) 0.83
An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases. J Med Chem (2014) 0.82
Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures. J Am Chem Soc (2010) 0.82
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res (2012) 0.82
Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome. Mol Biosyst (2012) 0.82
Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol (2012) 0.81
Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Bioorg Med Chem (2009) 0.81
Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. J Neuroinflammation (2014) 0.80
High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chem Biol Drug Des (2014) 0.80
Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction. Bioorg Med Chem Lett (2011) 0.80
Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method. Chembiochem (2010) 0.78
Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions. Anal Chem (2013) 0.78
Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization. Cell Biochem Biophys (2009) 0.78
Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Mol Biosyst (2012) 0.77
Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. PLoS Comput Biol (2013) 0.76
Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. Bioorg Med Chem (2011) 0.76
Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. ACS Chem Biol (2015) 0.75
Special series: Molecular chaperones in protein folding and disease. Biopolymers (2010) 0.75
The three cornerstones of chemical biology: innovative probes, new discoveries, and enabling tools. ACS Chem Biol (2012) 0.75