PubRank

Andrew D Westwell

Author PubWeight™ 33.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs. J Med Chem 2002 2.31
2 Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem 2006 1.51
3 4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. J Med Chem 2003 1.17
4 Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Res 2005 1.13
5 Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Rev Mol Med 2008 1.10
6 Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. J Med Chem 2010 1.06
7 Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1. Org Biomol Chem 2003 1.05
8 Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochem Biophys Res Commun 2007 1.00
9 Modulation of pRB/E2F functions in the regulation of cell cycle and in cancer. Curr Cancer Drug Targets 2005 1.00
10 The role of fluorine in medicinal chemistry. J Enzyme Inhib Med Chem 2007 1.00
11 Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. Eur J Med Chem 2010 0.99
12 Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochem Biophys Res Commun 2007 0.98
13 Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). J Med Chem 2008 0.98
14 Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochem Pharmacol 2003 0.96
15 Structure-activity analysis of 2'-modified cinnamaldehyde analogues as potential anticancer agents. Biochem Biophys Res Commun 2009 0.94
16 Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. Bioorg Med Chem Lett 2003 0.93
17 Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. Free Radic Biol Med 2009 0.91
18 Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. J Med Chem 2005 0.91
19 Metabolically stabilized benzothiazoles for imaging of amyloid plaques. J Med Chem 2007 0.90
20 2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther 2008 0.89
21 Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets. Biochem Biophys Res Commun 2006 0.89
22 Novel reaction products from the hypervalent iodine oxidation of hydroxylated stilbenes and isoflavones. Org Biomol Chem 2005 0.87
23 Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. J Med Chem 2005 0.85
24 Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Bioorg Med Chem Lett 2013 0.83
25 Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino-substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2-phenylbenzothiazoles. J Med Chem 2006 0.81
26 Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorg Med Chem Lett 2010 0.80
27 Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin. Am J Physiol Cell Physiol 2007 0.79
28 Oxidative stress in carcinogenesis: new synthetic compounds with dual effects upon free radicals and cancer. Curr Med Chem 2013 0.78
29 Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions. J Med Chem 2007 0.78
30 Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols'). Bioorg Med Chem Lett 2006 0.78
31 Hitting the chemotherapy jackpot: strategy, productivity and chemistry. Drug Discov Today 2004 0.77
32 The development of pro-apoptotic cancer therapeutics. Mini Rev Med Chem 2008 0.77
33 Synthesis and antioxidant properties of substituted 2-phenyl-1H-indoles. Bioorg Med Chem Lett 2013 0.77
34 Homology Modelling of Human E1 Ubiquitin Activating Enzyme. Lett Drug Des Discov 2010 0.76
35 The dark side of pharmaceutical chemistry. Future Med Chem 2012 0.75
36 The role and future potential of fluorinated biomarkers in positron emission tomography. Expert Opin Drug Discov 2010 0.75
37 Radiochemical synthesis of 2'-[18F]-labelled and 3'-[18F]-labelled nucleosides for positron emission tomography imaging. J Labelled Comp Radiopharm 2014 0.75
38 Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. Bioorg Med Chem Lett 2013 0.75
39 A novel radiochemical approach to 1-(2'-deoxy-2'-[(18) F]fluoro-β-d-arabinofuranosyl)cytosine ((18) F-FAC). J Labelled Comp Radiopharm 2014 0.75
40 Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents. Eur J Med Chem 2012 0.75
41 Synthesis and antitumour evaluation of novel 2-phenylbenzimidazoles. J Enzyme Inhib Med Chem 2008 0.75