Published in J Med Chem on January 12, 2006
Ethyl 2-(tert-butoxy-carbonyl-amino)-1,3-benzothia-zole-6-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.14
Benzothiazole bipyridine complexes of ruthenium(II) with cytotoxic activity. J Biol Inorg Chem (2007) 0.98
Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. Chem Res Toxicol (2012) 0.95
tert-Butyl N-[6-(N,N-dipropyl-carbamo-yl)-1,3-benzothia-zol-2-yl]carbamate. Acta Crystallogr Sect E Struct Rep Online (2010) 0.95
Pd(II)-catalyzed ortho arylation of 2-arylbenzothiazoles with aryl iodides via benzothiazole-directed C-H activation. J Organomet Chem (2012) 0.91
Characterization of the 4-(benzothiazol-2-yl)phenylnitrenium ion from a putative metabolite of a model antitumor drug. J Org Chem (2010) 0.83
Cytochrome P450-activated prodrugs. Future Med Chem (2013) 0.82
Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism. J Biol Chem (2011) 0.80
Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV. J Med Chem (2011) 0.80
Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole. Bioorg Med Chem Lett (2013) 0.78
Neuroprotective effects of the antioxidant action of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against ischemic neuronal damage in the brain. BMB Rep (2013) 0.78
Quinol derivatives as potential trypanocidal agents. Bioorg Med Chem (2011) 0.78
Neuroprotective effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against oxidative stress. Cell Mol Neurobiol (2011) 0.76
Methyl 2-[2-(tert-but-oxy-carbonyl-amino)-1,3-benzothia-zole-6-carboxamido]-acetate. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
2-(3H-1,3-Benzothia-zol-2-yl-idene)-propane-dial. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole. Saudi Pharm J (2010) 0.75
EGFR tyrosine kinase targeted compounds: in vitro antitumor activity and molecular modeling studies of new benzothiazole and pyrimido[2,1-b]benzothiazole derivatives. EXCLI J (2014) 0.75
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Temozolomide: mechanisms of action, repair and resistance. Curr Mol Pharmacol (2012) 1.82
FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest (2007) 1.39
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration. Mol Pharmacol (2004) 1.37
Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity (2007) 1.33
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells. Drug Metab Dispos (2004) 1.32
Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications. Oncology (2010) 1.26
Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat. J Mol Biol (2003) 1.19
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines. J Med Chem (2003) 1.17
Elucidation of thioredoxin as a molecular target for antitumor quinols. Cancer Res (2005) 1.13
Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Rev Mol Med (2008) 1.10
Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer. J Med Chem (2010) 1.06
Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1. Org Biomol Chem (2003) 1.05
TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells. Eur J Cancer (2006) 1.04
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Mol Pharmacol (2002) 1.03
Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl)benzothiazole in breast cancer cell lines. Breast Cancer Res Treat (2007) 1.02
Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts. J Med Chem (2002) 1.01
Metabolic activation of temozolomide measured in vivo using positron emission tomography. Cancer Res (2003) 1.01
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochem Biophys Res Commun (2007) 1.00
Modulation of pRB/E2F functions in the regulation of cell cycle and in cancer. Curr Cancer Drug Targets (2005) 1.00
The role of fluorine in medicinal chemistry. J Enzyme Inhib Med Chem (2007) 1.00
Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. Eur J Med Chem (2010) 0.99
Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochem Biophys Res Commun (2007) 0.98
Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648). J Med Chem (2008) 0.98
A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget (2014) 0.97
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles. Mol Cancer Ther (2002) 0.97
Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds. Biochem Pharmacol (2003) 0.96
Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity. FASEB J (2008) 0.94
Antitumor imidazotetrazines. 41. Conjugation of the antitumor agents mitozolomide and temozolomide to peptides and lexitropsins bearing DNA major and minor groove-binding structural motifs. J Med Chem (2002) 0.94
Structure-activity analysis of 2'-modified cinnamaldehyde analogues as potential anticancer agents. Biochem Biophys Res Commun (2009) 0.94
In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol Cancer Ther (2004) 0.93
6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ). Cancer Lett (2013) 0.93
Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. Bioorg Med Chem Lett (2003) 0.93
Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. J Med Chem (2005) 0.91
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. Free Radic Biol Med (2009) 0.91
Metabolically stabilized benzothiazoles for imaging of amyloid plaques. J Med Chem (2007) 0.90
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures. Org Biomol Chem (2009) 0.89
2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther (2008) 0.89
Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents. J Med Chem (2008) 0.89
Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets. Biochem Biophys Res Commun (2006) 0.89
High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Glycobiology (2010) 0.89
Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation. Clin Cancer Res (2006) 0.89
Semisynthesis and cytotoxic activities of andrographolide analogues. J Enzyme Inhib Med Chem (2006) 0.89
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents. Clin Cancer Res (2011) 0.88
Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity. J Med Chem (2005) 0.88
Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry (2007) 0.88
Novel reaction products from the hypervalent iodine oxidation of hydroxylated stilbenes and isoflavones. Org Biomol Chem (2005) 0.87
Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad. Org Biomol Chem (2004) 0.86
Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications. Soft Matter (2014) 0.86
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents. J Med Chem (2005) 0.85
Synthetic strategies to a telomere-targeted pentacyclic heteroaromatic salt. Org Biomol Chem (2006) 0.84
Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides. Bioorg Med Chem Lett (2013) 0.83
Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair. Oncology (2011) 0.83
The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models. Breast Cancer Res Treat (2004) 0.82
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Mol Cancer Ther (2011) 0.82
Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation. J Biol Chem (2010) 0.82
2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the aryl hydrocarbon receptor. Toxicol Appl Pharmacol (2009) 0.81
Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta Neuropathol Commun (2014) 0.81
Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. BMC Complement Altern Med (2014) 0.81