Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway.

PubWeight™: 1.72‹?› | Rank: Top 3%

🔗 View Article (PMID 16392963)

Published in Radiat Res on January 01, 2006

Authors

Ryuichi Okayasu1, Maki Okada, Atsushi Okabe, Miho Noguchi, Kaoru Takakura, Sentaro Takahashi

Author Affiliations

1: International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage-ku, Chiba-shi 263-8555, Japan. rokayasu@nirs.go.jp

Articles citing this

Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat Res (2010) 1.20

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res (2010) 1.15

Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. J Radiat Res (2012) 1.06

Heavy charged particle radiobiology: using enhanced biological effectiveness and improved beam focusing to advance cancer therapy. Mutat Res (2011) 1.05

Roles of the major, small, acid-soluble spore proteins and spore-specific and universal DNA repair mechanisms in resistance of Bacillus subtilis spores to ionizing radiation from X rays and high-energy charged-particle bombardment. J Bacteriol (2007) 1.01

The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons. Radiat Oncol (2010) 0.99

Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. PLoS One (2013) 0.94

Heavier ions with a different linear energy transfer spectrum kill more cells due to similar interference with the Ku-dependent DNA repair pathway. Radiat Res (2014) 0.90

The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells. Cancer Med (2015) 0.87

The potential value of the neutral comet assay and γH2AX foci assay in assessing the radiosensitivity of carbon beam in human tumor cell lines. Radiol Oncol (2013) 0.87

Transcription Factors in the Cellular Response to Charged Particle Exposure. Front Oncol (2016) 0.83

Role of the Nfo and ExoA apurinic/apyrimidinic endonucleases in radiation resistance and radiation-induced mutagenesis of Bacillus subtilis spores. J Bacteriol (2011) 0.82

Proteomic analysis of effects by x-rays and heavy ion in HeLa cells. Radiol Oncol (2014) 0.82

Single extreme low dose/low dose rate irradiation causes alteration in lifespan and genome instability in primary human cells. Br J Cancer (2007) 0.80

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells. Radiat Oncol (2015) 0.80

Mutational effects of γ-rays and carbon ion beams on Arabidopsis seedlings. J Radiat Res (2013) 0.80

Ku-dependent non-homologous end-joining as the major pathway contributes to sublethal damage repair in mammalian cells. Int J Radiat Biol (2015) 0.79

DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol (2015) 0.79

Modeling damage complexity-dependent non-homologous end-joining repair pathway. PLoS One (2014) 0.79

The Ku-dependent non-homologous end-joining pathway contributes to low-dose radiation-stimulated cell survival. J Cell Physiol (2011) 0.79

Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation. Oncol Lett (2015) 0.79

Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells. J Radiat Res (2012) 0.77

Increased Artemis levels confer radioresistance to both high and low LET radiation exposures. Radiat Oncol (2012) 0.77

Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem (2014) 0.77

Response to multiple radiation doses of human colorectal carcinoma cells infected with recombinant adenovirus containing dominant-negative Ku70 fragment. Int J Radiat Oncol Biol Phys (2010) 0.77

Resistance of Bacillus subtilis spore DNA to lethal ionizing radiation damage relies primarily on spore core components and DNA repair, with minor effects of oxygen radical detoxification. Appl Environ Microbiol (2013) 0.76

High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation. J Radiat Res (2013) 0.76

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget (2016) 0.76

DNA repair pathway choice at various conditions immediately post irradiation. Int J Radiat Biol (2016) 0.75

Comparison of the repair of potentially lethal damage after low- and high-LET radiation exposure, assessed from the kinetics and fidelity of chromosome rejoining in normal human fibroblasts. J Radiat Res (2013) 0.75

Comparison of gene expression response to neutron and x-ray irradiation using mouse blood. BMC Genomics (2017) 0.75

Hitting the right spot. EMBO Rep (2010) 0.75

Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons. Neural Regen Res (2014) 0.75

TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation. Mol Cancer Ther (2016) 0.75

Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair. Cancer Sci (2016) 0.75

The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining. Radiother Oncol (2016) 0.75

Drugging the Cancers Addicted to DNA Repair. J Natl Cancer Inst (2017) 0.75

DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV. Radiat Environ Biophys (2015) 0.75

Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life Sci Space Res (Amst) (2016) 0.75

Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving. Radiat Res (2017) 0.75

Investigation of the relative biological effectiveness and uniform isobiological killing effects of irradiation with a clinical carbon SOBP beam on DNA repair deficient CHO cells. Oncol Lett (2017) 0.75

Articles by these authors

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res (2011) 1.27

Optimized mounting of a polyethylene naphthalate scintillation material in a radiation detector. Appl Radiat Isot (2013) 1.08

The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation. J Radiat Res (2009) 1.01

Falling asleep while driving and automobile accidents among patients with obstructive sleep apnea-hypopnea syndrome. Psychiatry Clin Neurosci (2002) 0.98

Contributions of direct and indirect actions in cell killing by high-LET radiations. Radiat Res (2009) 0.96

Effect of astrocytic energy metabolism depressant on 14C-acetate uptake in intact rat brain. J Cereb Blood Flow Metab (2004) 0.96

Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts. Cancer Res (2005) 0.95

Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas. PLoS One (2013) 0.95

11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain. J Nucl Med (2007) 0.95

Feasibility studies of 4'-[methyl-(11)C]thiothymidine as a tumor proliferation imaging agent in mice. Nucl Med Biol (2008) 0.92

Intermittent reloading attenuates muscle atrophy through modulating Akt/mTOR pathway. Med Sci Sports Exerc (2008) 0.88

The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells. Cancer Med (2015) 0.87

Normal and abnormal neuronal migration in the developing cerebral cortex. J Med Invest (2002) 0.87

Assessment of ESR-CT imaging by comparison with autoradiography for the distribution of a blood-brain-barrier permeable spin probe, MC-PROXYL, to rodent brain. Magn Reson Imaging (2003) 0.86

Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain. J Cereb Blood Flow Metab (2008) 0.86

RNAi-mediated knockdown showing impaired cell survival in Drosophila wing imaginal disc. Gene Regul Syst Bio (2009) 0.86

High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells. Mutat Res (2008) 0.86

DNA double-strand break induction in Ku80-deficient CHO cells following boron neutron capture reaction. Radiat Oncol (2011) 0.82

Radiosensitization of normal human cells by LY294002: cell killing and the rejoining of DNA and interphase chromosome breaks. J Radiat Res (2003) 0.81

Mcl-1 depletion in apoptosis elicited by ionizing radiation in peritoneal resident macrophages of C3H mice. J Immunol (2007) 0.81

A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus. Int J Radiat Oncol Biol Phys (2007) 0.81

Importance of C/EBPβ binding and histone acetylation status in the promoter regions for induction of IGFBP-1, PRL, and Mn-SOD by cAMP in human endometrial stromal cells. Endocrinology (2013) 0.81

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans. Biochem Biophys Res Commun (2008) 0.80

OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect. Radiat Res (2013) 0.80

Potential mechanisms of aberrant DNA hypomethylation on the x chromosome in uterine leiomyomas. J Reprod Dev (2013) 0.80

Genome-wide analysis of histone modifications in human endometrial stromal cells. Mol Endocrinol (2014) 0.79

Cerebral acetylcholinesterase imaging: development of the radioprobes. Curr Top Med Chem (2007) 0.79

In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats. Neurosci Lett (2007) 0.79

Role of DNA-PKcs in the bystander effect after low- or high-LET irradiation. Int J Radiat Biol (2007) 0.79

Deciphering the molecular basis of the broad substrate specificity of alpha-glucosidase from Bacillus sp. SAM1606. J Biochem (2003) 0.79

Ectopic neurons in the hippocampus may be a cause of learning disability after prenatal exposure to X-rays in rats. J Radiat Res (2004) 0.78

Types and three-dimensional distribution of neuronal ectopias in the brain of mice prenatally subjected to X-irradiation. J Radiat Res (2002) 0.78

Significance of DNA polymerase I in in vivo processing of clustered DNA damage. Mutat Res (2013) 0.78

Mechanism of wavelength conversion in polystyrene doped with benzoxanthene: emergence of a complex. Sci Rep (2013) 0.78

Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells. J Radiat Res (2012) 0.77

Experimental model for irradiating a restricted region of the rat brain using heavy-ion beams. J Med Invest (2004) 0.77

One-step PCR to distinguish B virus from related primate alphaherpesviruses. Clin Diagn Lab Immunol (2002) 0.77

Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory impairment. Neurosci Lett (2004) 0.77

Melatonin protects the integrity of granulosa cells by reducing oxidative stress in nuclei, mitochondria, and plasma membranes in mice. J Reprod Dev (2014) 0.77

Comparison of 2-amino-[3-¹¹C]isobutyric acid and 2-deoxy-2-[¹⁸F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation. Nucl Med Commun (2012) 0.77

Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays. Mutat Res (2013) 0.77

Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions. Biochem Biophys Res Commun (2004) 0.77

A novel technique using DNA denaturation to detect multiply induced single-strand breaks in a hydrated plasmid DNA molecule by X-ray and 4He2+ ion irradiation. Radiat Prot Dosimetry (2010) 0.77

Combining high-performance liquid chromatography-positron detection and on-line microdialysis for animal metabolism study of positron emission tomography probes. J Chromatogr A (2008) 0.76

Induction of DNA double strand breaks by arsenite: comparative studies with DNA breaks induced by X-rays. DNA Repair (Amst) (2003) 0.76

Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography. Bioorg Med Chem (2011) 0.76

Efficacy of a B virus gD DNA vaccine for induction of humoral and cellular immune responses in Japanese macaques. Vaccine (2002) 0.76

Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1. J Radiat Res (2005) 0.76

Expression of brain-type fatty acid-binding protein (fabp7) in medaka during development. J Exp Zool B Mol Dev Evol (2008) 0.76

Ascorbic acid 2-glucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation. Mutat Res (2009) 0.75

Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. J Med Chem (2014) 0.75

Expression of neural cell adhesion molecule L1 in the brain of rats exposed to X-irradiation in utero. J Med Invest (2003) 0.75

Elastic multilayer bandages for chronic venous insufficiency: features of our technique. Ann Vasc Dis (2012) 0.75

Changes in histological construction and decrease in 3H-QNB binding in the rat brain after prenatal X-irradiation. J Radiat Res (2002) 0.75

Induced radioactivity in the blood of cancer patients following Boron Neutron Capture Therapy. J Radiat Res (2013) 0.75

Distribution of calbindin-D28K immunoreactive neurons in rat primary motor cortex. J Med Invest (2002) 0.75

Ventral intradural endodermal cyst in the cervical spine treated with anterior corpectomy--case report. Neurol Med Chir (Tokyo) (2011) 0.75

Impact of gamma irradiation on the transformation efficiency for extracellular plasmid DNA. J Environ Radioact (2007) 0.75

EPR studies of 5-bromouracil crystal after irradiation with X rays in the bromine K-edge region. Radiat Res (2004) 0.75

Radiation-induced apoptosis in peritoneal resident macrophages of C3H mice. J Radiat Res (2004) 0.75

Significant contamination of superoxide dismutases and catalases with lipopolysaccharide-like substances. Toxicol In Vitro (2004) 0.75

Comparison of the kinetics of radiation-induced apoptosis in DT40 cells irradiated with low and high doses of X rays. Radiat Res (2010) 0.75

Electronic structure of DNA nucleobases and their dinucleotides explored by soft X-ray spectroscopy. J Phys Chem A (2006) 0.75

Transfer of maternally administered fusogenic liposome-DNA complexes into monkey fetuses in a pregnancy model. J Gene Med (2002) 0.75

Imaging of activity of multidrug resistance-associated protein 1 in the lungs. Am J Respir Cell Mol Biol (2013) 0.75

A genetic mouse model carrying the nonfunctional xeroderma pigmentosum group G gene. Congenit Anom (Kyoto) (2003) 0.75