Published in Hum Mol Genet on January 10, 2006
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69
"Laminopathies": a wide spectrum of human diseases. Exp Cell Res (2007) 3.46
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression. Proc Natl Acad Sci U S A (2008) 2.58
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophys J (2008) 1.92
Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature (2013) 1.89
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci (2009) 1.74
Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev (2006) 1.73
Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med (2009) 1.70
Lamin-binding Proteins. Cold Spring Harb Perspect Biol (2010) 1.69
Role of A-type lamins in signaling, transcription, and chromatin organization. J Cell Biol (2009) 1.68
Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Hum Mol Genet (2008) 1.64
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. EMBO J (2006) 1.61
MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev Cell (2009) 1.59
Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48
Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. Am J Hum Genet (2009) 1.44
Abnormal proliferation and spontaneous differentiation of myoblasts from a symptomatic female carrier of X-linked Emery-Dreifuss muscular dystrophy. Neuromuscul Disord (2014) 1.42
Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. J Virol (2007) 1.41
Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J (2006) 1.40
Mouse models of the laminopathies. Exp Cell Res (2007) 1.40
The nuclear envelope at a glance. J Cell Sci (2010) 1.38
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J Cell Biol (2009) 1.36
Nuclear positioning in muscle development and disease. Front Physiol (2013) 1.14
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. PLoS Genet (2014) 1.13
The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity. J Biol Chem (2012) 1.13
Regulation of myoblast differentiation by the nuclear envelope protein NET39. Mol Cell Biol (2009) 1.11
Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Dev Cell (2013) 1.07
A-type nuclear lamins act as transcriptional repressors when targeted to promoters. Exp Cell Res (2009) 1.03
Lamins in development, tissue maintenance and stress. EMBO Rep (2012) 1.02
The nuclear envelope LEM-domain protein emerin. Nucleus (2013) 0.99
Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts. Mol Biol Cell (2013) 0.98
Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. BMC Med (2011) 0.97
Tissue specificity in the nuclear envelope supports its functional complexity. Nucleus (2013) 0.96
Nuclear membrane diversity: underlying tissue-specific pathologies in disease? Curr Opin Cell Biol (2015) 0.93
Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol (2015) 0.92
Networking in the nucleus: a spotlight on LEM-domain proteins. Curr Opin Cell Biol (2015) 0.90
Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis. Chromosome Res (2013) 0.89
The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections. J Virol (2008) 0.89
Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. PLoS One (2010) 0.88
Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation. Dev Dyn (2011) 0.86
Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. Elife (2015) 0.85
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans. Genome Biol (2014) 0.85
Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation. Cell Mol Life Sci (2009) 0.84
Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α. Hum Mol Genet (2013) 0.84
Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease. Cell Mol Life Sci (2012) 0.83
Limb-girdle and congenital muscular dystrophies: current diagnostics, management, and emerging technologies. Curr Neurol Neurosci Rep (2010) 0.83
Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology. Adv Exp Med Biol (2014) 0.83
Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol (2016) 0.83
Emerin in health and disease. Semin Cell Dev Biol (2013) 0.81
Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS One (2012) 0.81
A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal. PLoS One (2011) 0.81
Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus (2014) 0.80
Multiple novel functions of lamina associated polypeptide 2α in striated muscle. Nucleus (2011) 0.80
NET23/STING promotes chromatin compaction from the nuclear envelope. PLoS One (2014) 0.80
The Drosophila nuclear lamina protein otefin is required for germline stem cell survival. Dev Cell (2013) 0.79
Laminopathies disrupt epigenomic developmental programs and cell fate. Sci Transl Med (2016) 0.78
Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One (2015) 0.78
Lamina-associated polypeptide 1: protein interactions and tissue-selective functions. Semin Cell Dev Biol (2014) 0.78
Myotonic dystrophy protein kinase is critical for nuclear envelope integrity. J Biol Chem (2011) 0.77
Whole exome sequencing identifies a novel EMD mutation in a Chinese family with dilated cardiomyopathy. BMC Med Genet (2014) 0.77
Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development. Sci Rep (2016) 0.76
MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells. Dis Model Mech (2017) 0.75
Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Dev Biol (2016) 0.75
Lamin a truncation in Hutchinson-Gilford progeria. Science (2003) 8.01
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest (2004) 5.68
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
Astrocytes promote myelination in response to electrical impulses. Neuron (2006) 4.23
Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol (2002) 3.84
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol (2003) 3.80
Genomics, intellectual disability, and autism. N Engl J Med (2012) 3.74
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab (2005) 3.47
A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell (2010) 3.41
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature (2005) 3.31
A perinuclear actin cap regulates nuclear shape. Proc Natl Acad Sci U S A (2009) 3.12
Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem (2006) 3.02
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J Clin Invest (2004) 2.67
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol (2005) 2.66
An interactive power analysis tool for microarray hypothesis testing and generation. Bioinformatics (2006) 2.62
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
A progeroid syndrome in mice is caused by defects in A-type lamins. Nature (2003) 2.57
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J (2007) 2.51
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2004) 2.39
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell (2013) 2.38
Sources of variability and effect of experimental approach on expression profiling data interpretation. BMC Bioinformatics (2002) 2.31
Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest (2006) 2.23
Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration. Brain (2006) 2.22
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am J Hum Genet (2002) 2.20
Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures. Muscle Nerve (2009) 2.19
Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell (2012) 2.18
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17
Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod (2010) 2.12
Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins. Arterioscler Thromb Vasc Biol (2005) 2.12
Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta. J Clin Invest (2009) 2.10
Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol (2003) 2.06
SLC30A8 nonsynonymous variant is associated with recovery following exercise and skeletal muscle size and strength. Diabetes (2013) 2.05
Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expression. Am J Physiol Lung Cell Mol Physiol (2003) 2.04
Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors. J Proteome Res (2006) 2.04
Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. Dev Cell (2004) 2.01
The laminopathies: nuclear structure meets disease. Curr Opin Genet Dev (2003) 2.00
Interactively optimizing signal-to-noise ratios in expression profiling: project-specific algorithm selection and detection p-value weighting in Affymetrix microarrays. Bioinformatics (2004) 1.98
Variability in muscle size and strength gain after unilateral resistance training. Med Sci Sports Exerc (2005) 1.95
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophys J (2008) 1.92
Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell (2010) 1.90
ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Exerc (2006) 1.86
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. J Immunol (2002) 1.83
A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression. Blood (2010) 1.82
A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80
Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80
The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev Cell (2006) 1.78
Constitutive activation of MAPK cascade in acute quadriplegic myopathy. Ann Neurol (2004) 1.77
The nuclear lamins: flexibility in function. Nat Rev Mol Cell Biol (2012) 1.76
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics (2006) 1.67
Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B. Am J Pathol (2008) 1.65
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope. Proc Natl Acad Sci U S A (2007) 1.63
Declining trends in work-related morbidity and disability, 1993-1998: a comparison of survey estimates and compensation insurance claims. Am J Public Health (2003) 1.61
Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol (2007) 1.61
The laminopathies: the functional architecture of the nucleus and its contribution to disease. Annu Rev Genomics Hum Genet (2006) 1.61
Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. Hum Mol Genet (2005) 1.61
At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1. PLoS One (2009) 1.60
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet (2011) 1.60
ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol (1985) (2005) 1.57
Embryonic myogenesis pathways in muscle regeneration. Dev Dyn (2004) 1.57
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development (2003) 1.57
Aging and nuclear organization: lamins and progeria. Curr Opin Cell Biol (2004) 1.57
Differential dependency network analysis to identify condition-specific topological changes in biological networks. Bioinformatics (2008) 1.56
Microtubules underlie dysfunction in duchenne muscular dystrophy. Sci Signal (2012) 1.54
Probe set algorithms: is there a rational best bet? BMC Bioinformatics (2006) 1.53
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature (2008) 1.52
Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart. Neuromuscul Disord (2008) 1.52
ACTN3 and MLCK genotype associations with exertional muscle damage. J Appl Physiol (1985) (2005) 1.52
Functional characteristics of dystrophic skeletal muscle: insights from animal models. J Appl Physiol (1985) (2002) 1.50
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration. J Biol Chem (2002) 1.50
Functional polymorphisms associated with human muscle size and strength. Med Sci Sports Exerc (2004) 1.49
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration. J Cell Biol (2005) 1.49
The cooperative international neuromuscular research group Duchenne natural history study--a longitudinal investigation in the era of glucocorticoid therapy: design of protocol and the methods used. Muscle Nerve (2013) 1.48
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Hum Mol Genet (2006) 1.45
Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. J Cell Sci (2003) 1.44
Proteomics and systems biology in exercise and sport sciences research. Exerc Sport Sci Rev (2007) 1.43
Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome. Hum Mol Genet (2007) 1.42
Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol (2007) 1.42