Published in J Clin Invest on February 01, 2004
Mammalian heart renewal by pre-existing cardiomyocytes. Nature (2012) 5.56
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev (2008) 4.69
"Laminopathies": a wide spectrum of human diseases. Exp Cell Res (2007) 3.46
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu Rev Cell Dev Biol (2010) 3.04
Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A (2004) 2.89
Genetic causes of human heart failure. J Clin Invest (2005) 2.79
Death begets failure in the heart. J Clin Invest (2005) 2.72
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol (2005) 2.66
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J (2007) 2.51
Nuclear lamins. Cold Spring Harb Perspect Biol (2010) 2.22
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Mol Biol Cell (2005) 2.15
Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. J Invest Dermatol (2005) 2.06
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98
Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics. Nature (2013) 1.89
The lamin protein family. Genome Biol (2011) 1.85
When lamins go bad: nuclear structure and disease. Cell (2013) 1.84
Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev (2006) 1.73
The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics (2004) 1.72
Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med (2009) 1.70
Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection. J Virol (2005) 1.64
Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Hum Mol Genet (2008) 1.64
A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev (2006) 1.56
Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol (2009) 1.48
How do mutations in lamins A and C cause disease? J Clin Invest (2004) 1.47
Intermediate filaments take the heat as stress proteins. Trends Cell Biol (2010) 1.44
Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol (2007) 1.42
Drugs that modulate aging: the promising yet difficult path ahead. Transl Res (2013) 1.38
LINC complexes in health and disease. Nucleus (2011) 1.37
Nuclear morphology and deformation in engineered cardiac myocytes and tissues. Biomaterials (2010) 1.33
Lamins at a glance. J Cell Sci (2012) 1.30
Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation. PLoS Pathog (2008) 1.26
Lamins at the crossroads of mechanosignaling. Genes Dev (2015) 1.23
Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene. Circulation (2010) 1.21
Nuclear lamins and chromatin: when structure meets function. Adv Enzyme Regul (2008) 1.20
Nuclear lamina at the crossroads of the cytoplasm and nucleus. J Struct Biol (2011) 1.19
Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins. Nucleus (2011) 1.19
Nuclear positioning in muscle development and disease. Front Physiol (2013) 1.14
A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies. Nucleus (2012) 1.13
Homozygosity mapping and exome sequencing reveal GATAD1 mutation in autosomal recessive dilated cardiomyopathy. Circ Cardiovasc Genet (2011) 1.10
In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients. J Med Genet (2005) 1.07
Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. Hum Mol Genet (2008) 1.03
Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells. Aging (Albany NY) (2012) 1.00
Cellular mechanosensing: getting to the nucleus of it all. Prog Biophys Mol Biol (2014) 0.99
Navigating the epigenetic landscape of pluripotent stem cells. Nat Rev Mol Cell Biol (2012) 0.99
Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse. J Mol Cell Cardiol (2009) 0.99
Decreased bone formation and osteopenia in lamin a/c-deficient mice. PLoS One (2011) 0.99
The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm. Curr Opin Cell Biol (2011) 0.98
A comparative study of Drosophila and human A-type lamins. PLoS One (2009) 0.91
Gene expression, chromosome position and lamin A/C mutations. Nucleus (2011) 0.90
Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice. Circ Res (2009) 0.89
Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr Biol (Camb) (2015) 0.88
Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease. Semin Cell Dev Biol (2013) 0.88
Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. PLoS One (2010) 0.88
Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations. Nucleus (2013) 0.88
Systematic identification of pathological lamin A interactors. Mol Biol Cell (2014) 0.86
Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. PLoS One (2010) 0.86
Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy. PLoS One (2012) 0.85
Mechanics of the nucleus. Compr Physiol (2011) 0.85
Suppression of lamin A/C by short hairpin RNAs promotes adipocyte lineage commitment in mesenchymal progenitor cell line, ROB-C26. Histochem Cell Biol (2011) 0.85
LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice. PLoS One (2010) 0.84
The cellular mastermind(?)-mechanotransduction and the nucleus. Prog Mol Biol Transl Sci (2014) 0.84
Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases. J Lipid Res (2011) 0.84
Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation. Cell Mol Life Sci (2009) 0.84
Identification of a novel muscle A-type lamin-interacting protein (MLIP). J Biol Chem (2011) 0.84
Lamin A/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cells. PLoS One (2013) 0.83
Modifier locus of the skeletal muscle involvement in Emery-Dreifuss muscular dystrophy. Hum Genet (2010) 0.83
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease. Circ Res (2014) 0.83
Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. J Cell Biochem (2016) 0.82
Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy. PLoS One (2011) 0.82
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects. Exp Cell Res (2012) 0.82
Muscle structure influences utrophin expression in mdx mice. PLoS Genet (2014) 0.81
Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. PLoS One (2012) 0.81
Regulation of chromatin structure in the cardiovascular system. Circ J (2013) 0.81
Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells. PLoS One (2012) 0.81
Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner. Sci Rep (2016) 0.80
Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun (2015) 0.80
Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest (2015) 0.80
Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus (2014) 0.80
Beyond membrane channelopathies: alternative mechanisms underlying complex human disease. Acta Pharmacol Sin (2011) 0.78
Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting. Nucleus (2014) 0.78
Skin deep: what can the study of dermal fibroblasts teach us about dilated cardiomyopathy? J Mol Cell Cardiol (2009) 0.77
The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart. J Clin Med (2017) 0.77
Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations. Methods Enzymol (2015) 0.76
Another broken heart: loss of lamina-associated polypeptide 2alpha causes systolic dysfunction. Circ Res (2010) 0.75
Novel insights into the disease etiology of laminopathies. Rare Dis (2013) 0.75
LMNA gene single nucleotide polymorphisms in dilated cardiomyopathy of Han children. Int J Clin Exp Med (2015) 0.75
The expression of Lamin A mutant R321X leads to endoplasmic reticulum stress with aberrant Ca(2+) handling. J Cell Mol Med (2016) 0.75
What Should the Cardiologist know about Lamin Disease? Arrhythm Electrophysiol Rev (2012) 0.75
Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy. J Cell Sci (2016) 0.75
Recent advances in animal and human pluripotent stem cell modeling of cardiac laminopathy. Stem Cell Res Ther (2016) 0.75
Circulating autoantibodies to troponin I in Emery-Dreifuss muscular dystrophy. Acta Myol (2008) 0.75
Current insights into LMNA cardiomyopathies: Existing models and missing LINCs. Nucleus (2017) 0.75
Genetic Variations Leading to Familial Dilated Cardiomyopathy. Mol Cells (2016) 0.75
Non-farnesylated B-type lamin can tether chromatin inside the nucleus and its chromatin interaction requires the Ig-fold region. Chromosoma (2016) 0.75
Proteomic analysis of endothelin-1 targets in the regulation of cardiomyocyte proliferation. Curr Top Med Chem (2016) 0.75
Dilated Cardiomyopathy: Genetic Determinants and Mechanisms. Circ Res (2017) 0.75
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 35.74
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature (2003) 12.10
Lamin a truncation in Hutchinson-Gilford progeria. Science (2003) 8.01
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol (1999) 7.65
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95
Apoptosis in the failing human heart. N Engl J Med (1997) 6.35
Apoptosis in myocytes in end-stage heart failure. N Engl J Med (1996) 6.19
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med (1999) 5.61
Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nat Genet (1999) 5.04
Apoptosis: mechanisms and roles in pathology. Int Rev Exp Pathol (1991) 4.89
LMNA mutations in atypical Werner's syndrome. Lancet (2003) 4.81
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med (2000) 4.30
Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol (2002) 3.84
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nat Genet (2000) 3.73
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (2003) 3.71
The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol (1997) 3.70
Nuclear lamins: their structure, assembly, and interactions. J Struct Biol (1998) 3.54
Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science (2002) 3.38
Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res (2000) 3.28
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J Cell Sci (2001) 3.24
Chromatin unfolds. Cell (1996) 3.19
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum Mol Genet (2000) 3.08
The cellular basis of the length-tension relation in cardiac muscle. J Mol Cell Cardiol (1985) 3.04
Lamins: building blocks or regulators of gene expression? Nat Rev Mol Cell Biol (2002) 2.92
Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C. Am J Hum Genet (2002) 2.90
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med (2002) 2.89
Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation (1985) 2.65
A progeroid syndrome in mice is caused by defects in A-type lamins. Nature (2003) 2.57
Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Hum Mol Genet (2000) 2.52
Disruption of muscle architecture and myocardial degeneration in mice lacking desmin. J Cell Biol (1996) 2.44
Molecular mechanisms of inherited cardiomyopathies. Physiol Rev (2002) 2.32
Nuclear compartments and gene regulation. Curr Opin Genet Dev (1999) 2.30
Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation (1991) 2.28
Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. J Cell Sci (2001) 2.28
Modifying gene expression programs by altering core promoter chromatin architecture. Cell (2002) 2.22
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am J Hum Genet (2002) 2.20
A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin. Cell (1999) 2.12
A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Hum Mol Genet (2002) 2.10
Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. J Cell Sci (2001) 2.07
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol (1999) 2.05
Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy. J Cell Sci (2001) 2.05
Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J Cell Sci (2002) 2.02
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics (2002) 1.95
Lamin B constitutes an intermediate filament attachment site at the nuclear envelope. J Cell Biol (1987) 1.89
Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in human cells. J Cell Sci (1995) 1.85
Binding of two desmin derivatives to the plasma membrane and the nuclear envelope of avian erythrocytes: evidence for a conserved site-specificity in intermediate filament-membrane interactions. Proc Natl Acad Sci U S A (1987) 1.67
Apoptosis as a possible cause of gradual development of complete heart block and fatal arrhythmias associated with absence of the AV node, sinus node, and internodal pathways. Circulation (1996) 1.54
Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol (2000) 1.49
Null mutation in the desmin gene gives rise to a cardiomyopathy. J Mol Cell Cardiol (1997) 1.44
LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). J Hum Genet (2003) 1.40
A rapid optimized protocol for downward alkaline Southern blotting of DNA. Biotechniques (1993) 1.38
Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. J Med Genet (2003) 1.37
The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function. J Mol Cell Cardiol (1999) 1.22
A friend within the heart: natriuretic peptide receptor signaling. J Clin Invest (2003) 1.16
Desmin in muscle formation and maintenance: knockouts and consequences. Cell Struct Funct (1997) 1.15
Nuclear matrix and the regulation of gene expression: tissue specificity. J Cell Biochem (1994) 1.11
Structural plasticity of the cardiac nuclear pore complex in response to regulators of nuclear import. Circ Res (1999) 1.07
Unraveling the organization of the internal nuclear matrix: RNA-dependent anchoring of NuMA to a lamin scaffold. Exp Cell Res (2002) 1.02
Multiple linear regression is a useful alternative to traditional analyses of variance. Am J Physiol (1988) 0.99
Distribution of emerin and lamins in the heart and implications for Emery-Dreifuss muscular dystrophy. Hum Mol Genet (1999) 0.99
Characterization of adiposity and metabolism in Lmna-deficient mice. Biochem Biophys Res Commun (2002) 0.95
Hearts from mice lacking desmin have a myopathy with impaired active force generation and unaltered wall compliance. Cardiovasc Res (2002) 0.94
Changing the remodeling process in heart failure: basic mechanisms and laboratory results. Curr Opin Cardiol (1998) 0.93
Trans-cellular desmin-lamin B intermediate filament network in cardiac myocytes. J Mol Cell Cardiol (1993) 0.91
Apoptosis of myofibres and satellite cells: exercise-induced damage in skeletal muscle of the mouse. Neuropathol Appl Neurobiol (1998) 0.90
Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. Exp Cell Res (2003) 0.87
Effects of lactate on the relative contribution of Ca2+ extrusion mechanisms to relaxation in guinea-pig ventricular myocytes. J Physiol (1997) 0.86
The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin. Eur J Hum Genet (2001) 0.86
Single-beat determination of preload recruitable stroke work relationship: derivation and evaluation in conscious dogs. J Am Coll Cardiol (2000) 0.84
A simple technique for postembedding ultrastructural immunogold labeling. Ultrastruct Pathol (1992) 0.78
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res (2012) 15.41
Lamin a truncation in Hutchinson-Gilford progeria. Science (2003) 8.01
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest (2004) 5.68
Astrocytes promote myelination in response to electrical impulses. Neuron (2006) 4.23
Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol (2002) 3.84
Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network. Genome Biol (2003) 3.80
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol (2003) 3.80
A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell (2010) 3.41
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature (2005) 3.31
A perinuclear actin cap regulates nuclear shape. Proc Natl Acad Sci U S A (2009) 3.12
Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem (2006) 3.02
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol (2005) 2.66
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A (2009) 2.59
A progeroid syndrome in mice is caused by defects in A-type lamins. Nature (2003) 2.57
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J (2007) 2.51
Context-based tourism information filtering with a semantic rule engine. Sensors (Basel) (2012) 2.51
Intussusception risk after rotavirus vaccination in U.S. infants. N Engl J Med (2014) 2.41
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A (2004) 2.39
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell (2013) 2.38
Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res (2006) 2.30
Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest (2006) 2.23
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res (2008) 2.23
Penile length alterations following penile prosthesis surgery. Eur Urol (2006) 2.20
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. Am J Hum Genet (2002) 2.20
Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell (2012) 2.18
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A (2004) 2.17
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Overall quality of outcomes framework scores lower in practices in deprived areas. Br J Gen Pract (2006) 2.14
Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod (2010) 2.12
Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution. PLoS Genet (2009) 2.07
The laminopathies: nuclear structure meets disease. Curr Opin Genet Dev (2003) 2.00
Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol (2005) 1.98
Hibernating myocardium: chronically adapted to ischemia but vulnerable to sudden death. Circ Res (2004) 1.98
Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace (2013) 1.97
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet (2007) 1.97
Ablation for longstanding permanent atrial fibrillation: results from a randomized study comparing three different strategies. Heart Rhythm (2008) 1.96
MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 1.94
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophys J (2008) 1.92
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell (2010) 1.90
Distance, rurality and the need for care: access to health services in South West England. Int J Health Geogr (2004) 1.90
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. J Am Coll Cardiol (2003) 1.86
Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration. Hum Mol Genet (2006) 1.85
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy. Circ Res (2009) 1.83
A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80
The nuclear lamins: flexibility in function. Nat Rev Mol Cell Biol (2012) 1.76
1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant (2005) 1.76
To knockout in 129 or in C57BL/6: that is the question. Trends Genet (2004) 1.76
The histone variant macroH2A is an epigenetic regulator of key developmental genes. Nat Struct Mol Biol (2009) 1.75
SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol (2004) 1.75
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10. Eur J Neurosci (2005) 1.73
Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity. Insect Biochem Mol Biol (2002) 1.72
Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes. Development (2003) 1.70
Electrical isolation of the superior vena cava: an adjunctive strategy to pulmonary vein antrum isolation improving the outcome of AF ablation. J Cardiovasc Electrophysiol (2007) 1.68
Stretch-sensitive KCNQ1 mutation A link between genetic and environmental factors in the pathogenesis of atrial fibrillation? J Am Coll Cardiol (2007) 1.67
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010. Transfusion (2012) 1.66
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. J Infect Dis (2010) 1.64
Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther (2003) 1.63
Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies. Nephrol Dial Transplant (2007) 1.63
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope. Proc Natl Acad Sci U S A (2007) 1.63
Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol (2007) 1.61
Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Genes Chromosomes Cancer (2005) 1.61
The laminopathies: the functional architecture of the nucleus and its contribution to disease. Annu Rev Genomics Hum Genet (2006) 1.61
Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice. Hum Mol Genet (2005) 1.61
At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1. PLoS One (2009) 1.60
Calcimimetic inhibits late-stage cyst growth in ADPKD. J Am Soc Nephrol (2009) 1.58
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development (2003) 1.57
Aging and nuclear organization: lamins and progeria. Curr Opin Cell Biol (2004) 1.57
Effect of pravastatin on body composition and markers of cardiovascular disease in HIV-infected men--a randomized, placebo-controlled study. AIDS (2006) 1.56
High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell (2010) 1.56
Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. Liver Int (2013) 1.53
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature (2008) 1.52
Pulmonary vein antrum isolation for treatment of atrial fibrillation in patients with valvular heart disease or prior open heart surgery. Heart Rhythm (2004) 1.51
Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat. Spine (Phila Pa 1976) (2002) 1.50
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration. J Cell Biol (2005) 1.49
Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci U S A (2006) 1.48
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains. EMBO J (2011) 1.48
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Hum Mol Genet (2011) 1.47
Transthoracic echocardiographic predictors of left atrial appendage thrombus. Am J Cardiol (2005) 1.46
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Hum Mol Genet (2006) 1.45
FAST at MACH 20: clinical ultrasound aboard the International Space Station. J Trauma (2005) 1.44
Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. J Cell Sci (2003) 1.44
Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome. Hum Mol Genet (2007) 1.42
Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol (2007) 1.42
Dysfunction induced by ischemia versus edema: does edema matter? J Thorac Cardiovasc Surg (2009) 1.42
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells. J Immunol (2005) 1.41
Zone design for environment and health studies using pre-aggregated data. Soc Sci Med (2004) 1.40
Automated Greulich-Pyle bone age determination in children with chronic kidney disease. Pediatr Nephrol (2015) 1.39