Published in J Neurochem on January 09, 2006
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proc Natl Acad Sci U S A (2006) 1.61
The role of calcium-activated protease calpain in experimental retinal pathology. Surv Ophthalmol (2008) 1.23
New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet (2008) 1.19
Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis (2010) 1.15
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One (2010) 1.10
Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats. PLoS One (2011) 1.08
Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One (2014) 1.04
Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency. J Biol Chem (2012) 1.00
Mislocalized opsin and cAMP signaling: a mechanism for sprouting by rod cells in retinal degeneration. Invest Ophthalmol Vis Sci (2012) 0.99
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DNA methylation and differential gene regulation in photoreceptor cell death. Cell Death Dis (2014) 0.82
Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One (2015) 0.79
Retinal Cell Death Caused by Sodium Iodate Involves Multiple Caspase-Dependent and Caspase-Independent Cell-Death Pathways. Int J Mol Sci (2015) 0.79
Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells. Mol Vis (2013) 0.78
Multiple programmed cell death pathways are involved in N-methyl-N-nitrosourea-induced photoreceptor degeneration. Graefes Arch Clin Exp Ophthalmol (2015) 0.77
Loss of Pde6 reduces cell body Ca(2+) transients within photoreceptors. Cell Death Dis (2013) 0.77
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nat Commun (2015) 0.76
Imaging Ca2+ dynamics in cone photoreceptor axon terminals of the mouse retina. J Vis Exp (2015) 0.75
Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses. Invest Ophthalmol Vis Sci (2016) 0.75
Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice. PLoS One (2016) 0.75
Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa. Sci Rep (2016) 0.75
Reduced phosphoCREB in Müller glia during retinal degeneration in rd10 mice. Mol Vis (2017) 0.75
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet (2005) 3.49
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci (2011) 2.52
Integrative analysis of the mitochondrial proteome in yeast. PLoS Biol (2004) 2.31
Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nat Genet (2007) 2.16
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Photoreceptor cell death mechanisms in inherited retinal degeneration. Mol Neurobiol (2008) 1.94
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Proteomics (2007) 1.91
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem (2009) 1.71
WI-PHI: a weighted yeast interactome enriched for direct physical interactions. Proteomics (2007) 1.55
Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry. Mol Cell Proteomics (2010) 1.41
Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2. J Proteome Res (2010) 1.38
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet (2013) 1.32
Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. J Clin Invest (2011) 1.31
ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci (2009) 1.30
Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. J Neurosci (2007) 1.30
Approaching clinical proteomics: current state and future fields of application in fluid proteomics. Clin Chem Lab Med (2009) 1.27
Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag. Methods Mol Biol (2009) 1.18
Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell (2010) 1.18
Proteomic profiling of primary retinal Müller glia cells reveals a shift in expression patterns upon adaptation to in vitro conditions. Glia (2003) 1.17
A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol Cell Proteomics (2010) 1.15
Complement factor D in age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 1.14
A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa. Hum Mol Genet (2010) 1.13
PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem (2009) 1.12
A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics (2009) 1.11
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One (2010) 1.10
Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila. PLoS Genet (2010) 1.08
MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Am J Pathol (2011) 1.08
Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats. PLoS One (2011) 1.08
Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions. Curr Protoc Protein Sci (2009) 1.04
Comparative proteome analysis of native differentiated and cultured dedifferentiated human RPE cells. Invest Ophthalmol Vis Sci (2003) 1.04
Direct comparison of MS-based label-free and SILAC quantitative proteome profiling strategies in primary retinal Müller cells. Proteomics (2012) 1.04
GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells. Mol Cell Biol (2006) 1.04
Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J Biol Chem (2006) 1.03
Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer. J Pathol (2012) 1.03
Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCP. Biochim Biophys Acta (2010) 1.03
Two-dimensional electrophoresis of membrane proteins. Anal Bioanal Chem (2007) 1.02
CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina. Brain Res (2006) 1.02
LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation. J Cell Sci (2012) 1.01
Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments. Mol Cell Proteomics (2005) 1.01
Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach. Mol Cell Proteomics (2008) 1.00
Retinal degeneration 3 (RD3) protein inhibits catalytic activity of retinal membrane guanylyl cyclase (RetGC) and its stimulation by activating proteins. Biochemistry (2011) 1.00
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain. PLoS Genet (2013) 1.00
Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. J Neurochem (2007) 0.98
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One (2010) 0.98
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The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Hum Mol Genet (2011) 0.97
Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci (2006) 0.97
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A (2013) 0.96
Proteomic analysis of the porcine interphotoreceptor matrix. Proteomics (2005) 0.96
Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture. J Biol Chem (2011) 0.95
Structural and functional protein network analyses predict novel signaling functions for rhodopsin. Mol Syst Biol (2011) 0.95
Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells. Glia (2007) 0.95
Improved proteome analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis. Proteomics (2003) 0.95
Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis. J Proteome Res (2007) 0.95
Apoe, Mbl2, and Psp plasma protein levels correlate with diabetic phenotype in NZO mice--an optimized rapid workflow for SRM-based quantification. J Proteome Res (2013) 0.94
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res (2014) 0.94
Study of gene-targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP). Invest Ophthalmol Vis Sci (2009) 0.94
Identification and functional validation of novel autoantigens in equine uveitis. Mol Cell Proteomics (2006) 0.94
Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival. J Proteome Res (2006) 0.93
ER stress in retinal degeneration: a target for rational therapy? Trends Mol Med (2011) 0.93
Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell (2011) 0.93
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. J Pathol (2013) 0.92
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. J Proteomics (2012) 0.92
Photoreceptor rescue and toxicity induced by different calpain inhibitors. J Neurochem (2010) 0.92
The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation. Mol Neurodegener (2014) 0.91
Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina. Mol Vis (2010) 0.90
Integration between abutting retinas: role of glial structures and associated molecules at the interface. Invest Ophthalmol Vis Sci (2004) 0.90
GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration. Glia (2011) 0.90
Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2. J Proteomics (2012) 0.90
Changes in matrix metalloproteinase network in a spontaneous autoimmune uveitis model. Invest Ophthalmol Vis Sci (2011) 0.89
Equine recurrent uveitis--a spontaneous horse model of uveitis. Ophthalmic Res (2008) 0.89
S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI imaging. J Mol Med (Berl) (2011) 0.89
Functional and structural evaluation after AAV.RPE65 gene transfer in the canine model of Leber's congenital amaurosis. Adv Exp Med Biol (2003) 0.89
Down-regulation of pigment epithelium-derived factor in uveitic lesion associates with focal vascular endothelial growth factor expression and breakdown of the blood-retinal barrier. Proteomics (2007) 0.89
Serum protein identification and quantification of the corona of 5, 15 and 80 nm gold nanoparticles. Nanotechnology (2013) 0.89
Calpain activity in retinal degeneration. J Neurosci Res (2007) 0.88
Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein. J Biol Chem (2009) 0.87