Published in Dev Biol on January 09, 2006
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A (2011) 4.52
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature (2013) 2.55
New insights into epididymal biology and function. Hum Reprod Update (2009) 1.73
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
The R-spondin protein family. Genome Biol (2012) 1.62
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A (2008) 1.53
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep (2011) 1.47
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One (2012) 1.44
Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets. Acta Pharmacol Sin (2012) 1.17
Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2. Stem Cells (2013) 1.15
Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem (2008) 1.09
Multi-functional norrin is a ligand for the LGR4 receptor. J Cell Sci (2013) 1.01
GPR48 increases mineralocorticoid receptor gene expression. J Am Soc Nephrol (2011) 0.99
Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One (2012) 0.99
Lgr4 is a key regulator of prostate development and prostate stem cell differentiation. Stem Cells (2013) 0.97
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A (2014) 0.93
Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. J Biol Chem (2013) 0.87
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. Oncogene (2014) 0.87
LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. J Biol Chem (2014) 0.86
ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology (2014) 0.85
Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells. Cancer Manag Res (2014) 0.85
Analysis of LGR4 receptor distribution in human and mouse tissues. PLoS One (2013) 0.84
Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice. Asian J Androl (2015) 0.84
Morphological comparison of the testis and efferent ductules between wild-type and estrogen receptor alpha knockout mice during postnatal development. J Anat (2009) 0.82
Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse. Dev Dyn (2010) 0.81
Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway. PLoS One (2014) 0.81
Highly penetrant alterations of a critical region including BDNF in human psychopathology and obesity. Arch Gen Psychiatry (2012) 0.80
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation. PLoS One (2015) 0.79
LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats. Endocrinology (2013) 0.79
Lgr4 in ocular development and glaucoma. J Ophthalmol (2013) 0.79
A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals. PLoS One (2014) 0.78
Disruption of estrogen receptor signaling and similar pathways in the efferent ductules and initial segment of the epididymis. Spermatogenesis (2014) 0.78
Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapses. J Biol Chem (2014) 0.77
E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle (2016) 0.76
Segment- and cell-specific expression of D-type cyclins in the postnatal mouse epididymis. Gene Expr Patterns (2012) 0.75
Regeneration of thyroid follicles from primordial cells in a murine thyroidectomized model. Lab Invest (2017) 0.75
LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci (2016) 0.75
Intrinsic disorder in spondins and some of their interacting partners. Intrinsically Disord Proteins (2016) 0.75
G Protein-Coupled Receptor Signaling in Stem Cells and Cancer. Int J Mol Sci (2016) 0.75
Leucine-rich repeat-containing G protein coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition. J Biol Chem (2017) 0.75
Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse. Transgenic Res (2017) 0.75
MiR-449a regulates caprine endometrial stromal cell apoptosis and endometrial receptivity. Sci Rep (2017) 0.75
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem (2003) 4.79
Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med (2003) 3.91
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO J (2005) 2.16
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. N Engl J Med (2003) 2.16
Discordance of monozygotic twins for thyroid dysgenesis: implications for screening and for molecular pathophysiology. J Clin Endocrinol Metab (2002) 2.00
Detection and enumeration of coliforms in drinking water: current methods and emerging approaches. J Microbiol Methods (2002) 1.79
LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol (2009) 1.75
Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans. Nature (2009) 1.73
Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity. J Immunol (2005) 1.70
Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol Pharmacol (2004) 1.69
Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism. J Clin Endocrinol Metab (2004) 1.67
The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem (2003) 1.67
Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet (2008) 1.54
Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Mol Endocrinol (2002) 1.51
Chromosomal translocations as a mechanism of BRAF activation in two cases of large congenital melanocytic nevi. J Invest Dermatol (2007) 1.48
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep (2011) 1.47
Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers. Mol Pharmacol (2006) 1.47
The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle. J Biol Chem (2002) 1.46
Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci U S A (2005) 1.41
Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies. Mol Biol Cell (2002) 1.39
Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int (2009) 1.39
Allosteric properties of G protein-coupled receptor oligomers. Pharmacol Ther (2007) 1.39
Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree. J Am Soc Nephrol (2007) 1.38
Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2. FEBS Lett (2005) 1.35
Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J (2003) 1.35
Tonic signaling from O₂ sensors sets neural circuit activity and behavioral state. Nat Neurosci (2012) 1.34
Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant (2010) 1.34
A scalable pipeline for highly effective genetic modification of a malaria parasite. Nat Methods (2011) 1.31
Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron (2011) 1.30
A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Mol Endocrinol (2007) 1.27
Activation of human dental pulp progenitor/stem cells in response to odontoblast injury. Arch Oral Biol (2005) 1.27
Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid. J Clin Endocrinol Metab (2004) 1.21
GRIS: glycoprotein-hormone receptor information system. Mol Endocrinol (2006) 1.21
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A (2006) 1.19
Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse. Histochem Cell Biol (2005) 1.18
Minocycline protects against neurologic complications of rapid correction of hyponatremia. J Am Soc Nephrol (2010) 1.18
Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat. Brain Res (2009) 1.14
Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J Exp Med (2004) 1.14
Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis. Mol Pharmacol (2005) 1.12
An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor. J Biol Chem (2005) 1.08
Understanding ovarian hyperstimulation syndrome. Endocrine (2005) 1.07
A recombineering pipeline to make conditional targeting constructs. Methods Enzymol (2010) 1.07
Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells. J Biol Chem (2005) 1.07
Ectopic thyroid gland causing dysphonia: imaging and molecular studies. J Clin Endocrinol Metab (2010) 1.04
Structural differences in the hinge region of the glycoprotein hormone receptors: evidence from the sulfated tyrosine residues. Mol Endocrinol (2006) 1.04
Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity. Mol Endocrinol (2005) 1.03
Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity. Mol Endocrinol (2004) 1.02
Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium. Cell Rep (2013) 1.02
Rapid and sensitive enumeration of viable diluted cells of members of the family enterobacteriaceae in freshwater and drinking water. Appl Environ Microbiol (2002) 1.01
Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene. J Clin Endocrinol Metab (2008) 1.01
CCR5 and HIV infection. Receptors Channels (2002) 1.00
Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis. J Invest Dermatol (2008) 0.98
Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice. J Neurotrauma (2012) 0.98
Possible non-Mendelian mechanisms of thyroid dysgenesis. Endocr Dev (2007) 0.98
Why another conference on personalized medicine? Croat Med J (2012) 0.97
Small amplified RNA-SAGE: an alternative approach to study transcriptome from limiting amount of mRNA. Nucleic Acids Res (2003) 0.97
The cost of scientific excellence - could it be expensive and out of reach? Croat Med J (2016) 0.97
Single-nucleotide polymorphism genotyping by melting analysis of dual-labeled probes: examples using factor V Leiden and prothrombin 20210A mutations. Clin Chem (2003) 0.95
Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochim Biophys Acta (2002) 0.94
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome. J Clin Endocrinol Metab (2004) 0.94
Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci. J Clin Endocrinol Metab (2005) 0.93
Thyroid dysgenesis: multigenic or epigenetic ... or both? Endocrinology (2005) 0.93
Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models. Biochim Biophys Acta (2004) 0.92
Specificity and promiscuity of gonadotropin receptors. Reproduction (2005) 0.91
Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands. Gen Comp Endocrinol (2007) 0.91
Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor. Mol Endocrinol (2004) 0.91
Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion. J Neurotrauma (2013) 0.91
Astrocytes are an early target in osmotic demyelination syndrome. J Am Soc Nephrol (2011) 0.91
Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus. J Rheumatol (2009) 0.90
Genetically modified stem cells for the treatment of neurological diseases. Front Biosci (Elite Ed) (2012) 0.90
In vivo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer's-like disease: MRI approach. Anat Rec (Hoboken) (2009) 0.89
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. Hum Mutat (2008) 0.89
Tissue factor: a mini-review. J Tissue Eng Regen Med (2007) 0.88
Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands. PLoS One (2010) 0.88
Multifaceted role of galectin-3 on human glioblastoma cell motility. Biochem Biophys Res Commun (2004) 0.87
GPR3 receptor, a novel actor in the emotional-like responses. PLoS One (2009) 0.86
Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem Biophys Res Commun (2005) 0.86
S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients. J Neuropathol Exp Neurol (2002) 0.86
Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells. Biochim Biophys Acta (2008) 0.86
Assessment of a new technique combining a viability test, whole-cell hybridization and laser-scanning cytometry for the direct counting of viable Enterobacteriaceae cells in drinking water. FEMS Microbiol Lett (2005) 0.85
Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension. Cardiovasc Res (2003) 0.85
Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers. Nat Commun (2012) 0.84
Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis. Stem Cells Transl Med (2013) 0.84
A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist. FEBS Lett (2002) 0.83
Incidence of chromosomal mosaicism in human embryos at different developmental stages analyzed by fluorescence in situ hybridization. Genet Test (2003) 0.83
Modelling and treating amyotrophic lateral sclerosis through induced-pluripotent stem cells technology. Curr Stem Cell Res Ther (2016) 0.83
Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1. Hum Genet (2005) 0.83
Evolutionary conservation of bursicon in the animal kingdom. Gen Comp Endocrinol (2006) 0.83
Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation. Biochim Biophys Acta (2006) 0.82
Relationship between genome and epigenome--challenges and requirements for future research. BMC Genomics (2014) 0.82
Pseudodominant inheritance of goitrous congenital hypothyroidism caused by TPO mutations: molecular and in silico studies. J Clin Endocrinol Metab (2007) 0.82
The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Nat Neurosci (2005) 0.81
Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG. Mol Endocrinol (2002) 0.81
Sinus grafting using recombinant human tissue factor, platelet-rich plasma gel, autologous bone, and anorganic bovine bone mineral xenograft: histologic analysis and case reports. Int J Oral Maxillofac Implants (2005) 0.81
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). Eur J Pediatr (2008) 0.81
Aquaporin-4 overexpression in rat ALS model. Anat Rec (Hoboken) (2009) 0.81
Human tooth culture: a study model for reparative dentinogenesis and direct pulp capping materials biocompatibility. J Biomed Mater Res B Appl Biomater (2008) 0.81
Live monitoring of brain damage in the rat model of amyotrophic lateral sclerosis. Gen Physiol Biophys (2009) 0.80
Lack of minocycline efficiency in genetic models of Huntington's disease. Neuromolecular Med (2007) 0.80