Published in J Biol Chem on December 28, 2005
Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol (2009) 5.43
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A (2007) 3.98
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature (2011) 3.40
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88
The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15. Mol Cell (2010) 2.32
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proc Natl Acad Sci U S A (2006) 2.30
Interferon-stimulated gene 15 and the protein ISGylation system. J Interferon Cytokine Res (2010) 2.14
ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proc Natl Acad Sci U S A (2010) 1.89
Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation. J Virol (2007) 1.75
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection. J Virol (2008) 1.73
Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. Mol Cell Biol (2010) 1.61
Vaccinia virus E3 protein prevents the antiviral action of ISG15. PLoS Pathog (2008) 1.57
Screen for ISG15-crossreactive deubiquitinases. PLoS One (2007) 1.57
Impaired lung homeostasis in neonatal mice exposed to cigarette smoke. Am J Respir Cell Mol Biol (2007) 1.56
Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. J Virol (2009) 1.55
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators. PLoS Pathog (2016) 1.39
ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. J Virol (2008) 1.38
Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins. J Biol Chem (2010) 1.32
Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein. J Virol (2010) 1.28
ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog (2011) 1.26
The antiviral activities of ISG15. J Mol Biol (2013) 1.20
HECT E3s and human disease. BMC Biochem (2007) 1.19
ISG15 as a novel tumor biomarker for drug sensitivity. Mol Cancer Ther (2008) 1.19
The basis for selective E1-E2 interactions in the ISG15 conjugation system. J Biol Chem (2008) 1.17
Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. Ann Neurol (2010) 1.16
Interferon-induced ISG15 pathway: an ongoing virus-host battle. Trends Microbiol (2013) 1.16
Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers. Blood (2010) 1.11
Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J Virol (2012) 1.07
Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06
Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag. Retrovirology (2011) 1.05
Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus. Proc Natl Acad Sci U S A (2011) 1.05
Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag. PLoS Pathog (2010) 1.03
Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. Biochem Biophys Res Commun (2007) 1.02
Isg15 controls p53 stability and functions. Cell Cycle (2014) 1.02
Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. J Virol (2011) 1.02
Antiviral Properties of ISG15. Viruses (2010) 1.02
Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists. BMC Immunol (2007) 1.01
Animal HECT ubiquitin ligases: evolution and functional implications. BMC Evol Biol (2010) 1.00
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci U S A (2015) 0.99
HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells. PLoS One (2012) 0.96
A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. PLoS One (2011) 0.91
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation. J Biol Chem (2012) 0.91
ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle. J Virol (2014) 0.88
ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection. J Virol (2013) 0.88
Emerging roles for immunomodulatory functions of free ISG15. J Interferon Cytokine Res (2013) 0.86
HyperISGylation of Old World monkey ISG15 in human cells. PLoS One (2008) 0.86
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway. J Virol (2015) 0.85
A genomic survey of HECT ubiquitin ligases in eukaryotes reveals independent expansions of the HECT system in several lineages. Genome Biol Evol (2013) 0.84
Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. J Biol Chem (2008) 0.83
Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. J Virol (2014) 0.82
Evolution of plant HECT ubiquitin ligases. PLoS One (2013) 0.81
Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis. Sci Rep (2015) 0.80
Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. PLoS One (2012) 0.80
Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins. DNA Repair (Amst) (2015) 0.80
Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners. EMBO Rep (2015) 0.80
Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division. Mol Pharm (2013) 0.79
Budding of Enveloped Viruses: Interferon-Induced ISG15-Antivirus Mechanisms Targeting the Release Process. Adv Virol (2012) 0.79
The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem (2014) 0.79
Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun (2016) 0.79
ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation. J Virol (2016) 0.77
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation. Proc Natl Acad Sci U S A (2015) 0.77
The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers. Front Genet (2016) 0.76
Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export. Retrovirology (2014) 0.76
Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res (2014) 0.75
The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination. Oncotarget (2016) 0.75
Ubiquitin and ubiquitin-like proteins in cardiac disease and protection. Curr Drug Targets (2015) 0.75
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Nat Commun (2016) 0.75
Type 1 interferons inhibit myotube formation independently of upregulation of interferon-stimulated gene 15. PLoS One (2013) 0.75
Structural basis of the specificity of USP18 toward ISG15. Nat Struct Mol Biol (2017) 0.75
Intact Pneumococci Trigger Transcription of Interferon-Related Genes in Human Monocytes, while Fragmented, Autolyzed Bacteria Subvert This Response. Infect Immun (2017) 0.75
The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res (2015) 0.75
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity. Sci Rep (2017) 0.75
Cell type-dependent regulation of free ISG15 levels and ISGylation. J Cell Commun Signal (2017) 0.75
Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases. Cell Mol Life Sci (2017) 0.75
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature (2006) 3.88
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proc Natl Acad Sci U S A (2005) 3.74
The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway. Proc Natl Acad Sci U S A (2006) 3.50
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A (2004) 3.16
Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology (2006) 3.00
Discovery-based science education: functional genomic dissection in Drosophila by undergraduate researchers. PLoS Biol (2005) 2.33
The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15. Mol Cell (2010) 2.32
Structures of influenza A proteins and insights into antiviral drug targets. Nat Struct Mol Biol (2010) 2.31
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology (2007) 2.30
Targeted, high-depth, next-generation sequencing of cancer genes in formalin-fixed, paraffin-embedded and fine-needle aspiration tumor specimens. J Mol Diagn (2013) 2.27
Polyubiquitination by HECT E3s and the determinants of chain type specificity. Mol Cell Biol (2009) 2.17
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science (2012) 2.06
The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target. J Virol (2006) 2.05
Structural basis for suppression of a host antiviral response by influenza A virus. Proc Natl Acad Sci U S A (2008) 2.02
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. J Virol (2007) 1.92
ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proc Natl Acad Sci U S A (2010) 1.89
Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is unique. Proc Natl Acad Sci U S A (2002) 1.78
The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. EMBO J (2005) 1.76
The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells. J Virol (2007) 1.75
Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode. Biochemistry (2004) 1.72
The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae. J Biol Chem (2006) 1.68
A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol Cell (2013) 1.65
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat Struct Mol Biol (2007) 1.56
Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. J Virol (2009) 1.55
Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. EMBO J (2003) 1.55
Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J Virol (2008) 1.47
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host Microbe (2013) 1.45
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Influenza virus virulence and its molecular determinants. Adv Virus Res (2005) 1.44
Regulation of catalytic activities of HECT ubiquitin ligases. Biochem Biophys Res Commun (2007) 1.42
Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. J Biol Chem (2007) 1.40
Structure and function of a HECT domain ubiquitin-binding site. EMBO Rep (2011) 1.35
Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells. J Virol (2008) 1.35
The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases. J Biol Chem (2004) 1.32
Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins. J Biol Chem (2010) 1.32
Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies. Mol Biol Cell (2006) 1.29
Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription. Virology (2010) 1.26
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes Infect (2006) 1.22
The basis for selective E1-E2 interactions in the ISG15 conjugation system. J Biol Chem (2008) 1.17
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. J Virol (2005) 1.17
Interferon-induced ISG15 pathway: an ongoing virus-host battle. Trends Microbiol (2013) 1.16
The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins. J Virol (2011) 1.13
The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol (2010) 1.13
Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells (2006) 1.13
A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p. J Biol Chem (2004) 1.09
HPV E6, E6AP and cervical cancer. BMC Biochem (2008) 1.08
Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus. Proc Natl Acad Sci U S A (2011) 1.05
Iron overload is rare in patients homozygous for the H63D mutation. Can J Gastroenterol Hepatol (2014) 1.04
Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions. J Biol Chem (2011) 1.03
Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag. PLoS Pathog (2010) 1.03
Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6. J Med Virol (2006) 1.01
Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein. MBio (2012) 1.01
Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis. J Virol (2012) 1.00
Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase. Cancer Res (2002) 0.99
Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses. J Virol (2012) 0.98
Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel. BMC Med Genomics (2014) 0.95
Expression and assay of HECT domain ligases. Methods Enzymol (2005) 0.90
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. J Virol (2012) 0.87
Identification and Validation of ISG15 Target Proteins. Subcell Biochem (2010) 0.86
Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay. J Biomol Screen (2012) 0.82
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. Bioorg Med Chem Lett (2011) 0.81
The ISG15 conjugation system. Methods Mol Biol (2012) 0.81
Properties of the ISG15 E1 enzyme UbE1L. Methods Enzymol (2005) 0.78
High-level expression and purification of recombinant E1 enzyme. Methods Enzymol (2005) 0.77
Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76
Backbone and Ile-δ1, Leu, Val methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein. Biomol NMR Assign (2011) 0.75
Assemble, replicate, remodel and evade. Curr Opin Virol (2012) 0.75