Published in J Cell Sci on February 01, 2006
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol (2006) 3.56
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J (2009) 2.00
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell (2007) 1.77
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic. Mol Biol Cell (2008) 1.58
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J (2011) 1.57
Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci (2012) 1.29
Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14
Endosomal type Iγ PIP 5-kinase controls EGF receptor lysosomal sorting. Dev Cell (2013) 1.10
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα. Mol Biol Cell (2013) 1.08
Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα. Mol Biol Cell (2010) 1.08
Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}. J Biol Chem (2009) 1.04
Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons. Proc Natl Acad Sci U S A (2009) 1.01
Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol Biol Cell (2012) 1.00
Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell Death Dis (2010) 0.98
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res (2010) 0.98
Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. Cell (2016) 0.94
Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current. Proc Natl Acad Sci U S A (2014) 0.94
Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development (2012) 0.93
BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. J Cell Biol (2014) 0.93
Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. J Biol Chem (2012) 0.92
Regulation of Golgi function via phosphoinositide lipids. Semin Cell Dev Biol (2009) 0.92
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. Prog Lipid Res (2013) 0.89
Detergent-free isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles. J Lipid Res (2010) 0.88
Signaling at the Golgi. Cold Spring Harb Perspect Biol (2011) 0.88
Regulation of Ca2+ entry by inositol lipids in mammalian cells by multiple mechanisms. Cell Calcium (2009) 0.88
Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90. J Biol Chem (2011) 0.86
Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat Commun (2014) 0.86
Emerging roles of PtdIns(4,5)P2 - beyond the plasma membrane. J Cell Sci (2015) 0.84
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. J Cell Biol (2015) 0.84
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2015) 0.83
Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch. EMBO Rep (2012) 0.82
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy. Protein Cell (2014) 0.82
Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci (2014) 0.81
Molecular brightness analysis reveals phosphatidylinositol 4-Kinase IIβ association with clathrin-coated vesicles in living cells. Biophys J (2012) 0.81
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. J Cell Sci (2016) 0.80
PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. Mol Biol Cell (2016) 0.79
The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep (2014) 0.79
Raft-like membranes from the trans-Golgi network and endosomal compartments. Nat Protoc (2013) 0.79
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme. Mol Neurobiol (2014) 0.79
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. Proc Natl Acad Sci U S A (2015) 0.78
CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum. J Lipid Res (2011) 0.77
Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun (2016) 0.77
Lipid kinases as therapeutic targets for chronic pain. Pain (2015) 0.76
Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype. Mol Biol Cell (2016) 0.75
Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network. Proc Natl Acad Sci U S A (2017) 0.75
Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization. Sci Rep (2016) 0.75
Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet (2012) 4.54
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Nat Cell Biol (2007) 2.35
Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci (2007) 2.18
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci (2008) 1.89
The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2. J Cell Sci (2008) 1.89
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment. J Cell Sci (2003) 1.78
Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat Cell Biol (2004) 1.76
Function and dysfunction of the PI system in membrane trafficking. EMBO J (2008) 1.75
The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130. Mol Biol Cell (2007) 1.74
Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes. Mol Biol Cell (2002) 1.69
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nat Cell Biol (2005) 1.67
Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation. Mol Biol Cell (2008) 1.66
Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Traffic (2006) 1.65
Secretory cargo regulates the turnover of COPII subunits at single ER exit sites. Curr Biol (2006) 1.60
Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. J Cell Sci (2009) 1.56
Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. J Cell Sci (2006) 1.56
Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev (2005) 1.44
Assembly, organization, and function of the COPII coat. Histochem Cell Biol (2007) 1.41
Sedlin controls the ER export of procollagen by regulating the Sar1 cycle. Science (2012) 1.41
Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps. Mol Biol Cell (2009) 1.39
Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63. Mol Cell Biol (2006) 1.32
Lipid-transfer proteins in biosynthetic pathways. Curr Opin Cell Biol (2008) 1.26
ER exit sites--localization and control of COPII vesicle formation. FEBS Lett (2009) 1.25
PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. J Cell Sci (2005) 1.25
OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin. EMBO J (2011) 1.21
Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts. Pathogenetics (2008) 1.20
Tetraspanins in human epithelial malignancies. J Pathol (2010) 1.19
All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding. Biochem Biophys Res Commun (2008) 1.15
CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium. Mol Cancer Res (2009) 1.15
The tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility. J Cell Sci (2008) 1.11
Tetraspanin CD151 mediates papillomavirus type 16 endocytosis. J Virol (2013) 1.11
The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J Biol Chem (2003) 1.08
GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex. J Biol Chem (2009) 1.07
ER-to-Golgi transport: form and formation of vesicular and tubular carriers. Biochim Biophys Acta (2005) 1.07
Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum. Biochem J (2003) 1.06
Large pleiomorphic traffic intermediates in the secretory pathway. Curr Opin Cell Biol (2005) 1.05
Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. Cancer Res (2010) 1.04
Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. J Cell Sci (2003) 1.04
Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport. Traffic (2008) 1.04
Tetraspanin CD151 regulates transforming growth factor beta signaling: implication in tumor metastasis. Cancer Res (2010) 1.04
Tetraspanin CD151 regulates growth of mammary epithelial cells in three-dimensional extracellular matrix: implication for mammary ductal carcinoma in situ. Cancer Res (2010) 1.03
The intracellular transport of chylomicrons requires the small GTPase, Sar1b. Curr Opin Lipidol (2004) 1.03
The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. Dev Cell (2012) 1.02
Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons. Proc Natl Acad Sci U S A (2009) 1.01
Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts. J Biol Chem (2005) 1.00
Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem J (2009) 1.00
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res (2010) 0.98
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. Nature (2013) 0.98
Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. J Biol Chem (2005) 0.98
A role for Tctex-1 (DYNLT1) in controlling primary cilium length. Eur J Cell Biol (2011) 0.97
Gangliosides play an important role in the organization of CD82-enriched microdomains. Biochem J (2006) 0.96
Specific functions of BIG1 and BIG2 in endomembrane organization. PLoS One (2010) 0.95
Tetraspanin CD9 in cell migration. Biochem Soc Trans (2011) 0.94
The phosphatidylinositol 4-kinases: don't call it a comeback. Subcell Biochem (2012) 0.93
Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin. J Biol Chem (2008) 0.93
Rab6 and myosin II at the cutting edge of membrane fission. Nat Cell Biol (2010) 0.93
Coming out of the dark: the evolving role of fluorescence imaging in drug delivery research. Adv Drug Deliv Rev (2005) 0.92
Microtubule motors mediate endosomal sorting by maintaining functional domain organization. J Cell Sci (2013) 0.90
The role of motor proteins in endosomal sorting. Biochem Soc Trans (2011) 0.90
Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81. J Virol (2012) 0.90
The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Biochem Soc Symp (2005) 0.90
The role of tetraspanin CD63 in antigen presentation via MHC class II. Eur J Immunol (2011) 0.89
Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis. Haematologica (2013) 0.89
Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. Prog Lipid Res (2013) 0.89
A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2. J Cell Sci (2013) 0.88
Detergent-free isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles. J Lipid Res (2010) 0.88
Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells. Biochem J (2003) 0.88
LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells. Traffic (2010) 0.88
Measuring the induction or inhibition of apoptosis by HPV proteins. Methods Mol Med (2005) 0.88
The effect of cell-ECM adhesion on signalling via the ErbB family of growth factor receptors. Biochem Soc Trans (2011) 0.88
Phosphoinositides in Golgi complex function. Subcell Biochem (2012) 0.87
Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport. Eur J Cell Biol (2004) 0.87
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells. Mol Pharmacol (2006) 0.86
Binding to syntenin-1 protein defines a new mode of ubiquitin-based interactions regulated by phosphorylation. J Biol Chem (2011) 0.86
Preparation of membrane rafts. Methods Mol Biol (2009) 0.86
Optimising the precision for localising fluorescent proteins in living cells by 2D Gaussian fitting of digital images: application to COPII-coated endoplasmic reticulum exit sites. Eur Biophys J (2008) 0.85
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J (2008) 0.85
Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis. J Cell Sci (2010) 0.85
Circulating DBP level and prognosis in operated lung cancer: an exploration of pathophysiology. Eur Respir J (2012) 0.84
Characterization of E-cadherin-dependent and -independent events in a new model of c-Fos-mediated epithelial-mesenchymal transition. Exp Cell Res (2006) 0.84
Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export. Trends Cell Biol (2004) 0.84
Cell biology: Collagen secretion explained. Nature (2012) 0.84
Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. J Biol Chem (2013) 0.82
Connecting vesicular transport with lipid synthesis: FAPP2. Biochim Biophys Acta (2012) 0.81
Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture. Mol Biol Cell (2013) 0.81
Characterization of human Sec16B: indications of specialized, non-redundant functions. Sci Rep (2011) 0.81
A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection. J Gen Virol (2013) 0.81
Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells. Biochem Soc Symp (2005) 0.81
Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation. Biol Cell (2014) 0.81
Quantification of multiple phosphatidylinositol 4-kinase isozyme activities in cell extracts. Methods Mol Biol (2009) 0.80
Cargo loading at the ER. Mol Membr Biol (2010) 0.80
Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases. Mol Neurobiol (2012) 0.80
Cystinosis: clinical presentation, pathogenesis and treatment. Pediatr Endocrinol Rev (2014) 0.79