Published in Nat Cell Biol on March 27, 2005
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell (2007) 2.15
Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex. Nat Cell Biol (2010) 1.94
Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts. Science (2008) 1.72
Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol (2008) 1.58
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GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. Mol Biol Cell (2008) 1.23
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol (2010) 1.11
Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J Biol Chem (2005) 1.10
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Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. Mol Biol Cell (2011) 1.07
Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets. Biochem Pharmacol (2011) 1.03
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation. Mol Cell Biol (2010) 1.01
ARF1-mediated actin polymerization produces movement of artificial vesicles. Proc Natl Acad Sci U S A (2007) 1.00
Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii. Infect Immun (2009) 0.99
Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. J Biol Chem (2012) 0.98
Connecting the cytoskeleton to the endoplasmic reticulum and Golgi. Curr Biol (2014) 0.97
The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. Neuron (2013) 0.97
Retrograde Shiga toxin trafficking is regulated by ARHGAP21 and Cdc42. Mol Biol Cell (2009) 0.97
Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. Proc Natl Acad Sci U S A (2011) 0.96
Regulation of cell death by recycling endosomes and golgi membrane dynamics via a pathway involving Src-family kinases, Cdc42 and Rab11a. Mol Biol Cell (2009) 0.94
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Cdc42 regulates microtubule-dependent Golgi positioning. Traffic (2010) 0.91
AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis. Mol Biol Cell (2007) 0.91
Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly. Mol Biol Cell (2006) 0.91
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ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition. J Biol Chem (2012) 0.88
Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. J Cell Sci (2010) 0.86
Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin β1 cycling and actin remodeling. Proc Natl Acad Sci U S A (2012) 0.84
Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe. Mol Biol Cell (2010) 0.84
AGAP2 regulates retrograde transport between early endosomes and the TGN. J Cell Sci (2010) 0.84
Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src. Cytoskeleton (Hoboken) (2014) 0.83
Actin acting at the Golgi. Histochem Cell Biol (2013) 0.82
PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity. Mol Biol Cell (2014) 0.81
Experience-dependent gene expression in adult visual cortex. Cereb Cortex (2009) 0.80
Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol (2016) 0.80
ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells. Cell Death Dis (2016) 0.80
The interactome of a PTB domain-containing adapter protein, Odin, revealed by SILAC. J Proteomics (2010) 0.80
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. Membranes (Basel) (2015) 0.79
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus. J Mol Neurosci (2012) 0.79
Crosstalk of small GTPases at the Golgi apparatus. Small GTPases (2012) 0.79
Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking. Mol Biol Cell (2015) 0.79
CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS One (2014) 0.78
Cdc42 and Cellular Polarity: Emerging Roles at the Golgi. Trends Cell Biol (2015) 0.78
Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases. J Biol Chem (2013) 0.77
Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK. PLoS One (2015) 0.76
Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. J Biol Chem (2015) 0.76
Identification of novel NPRAP/δ-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. PLoS One (2011) 0.75
ARF1 at the crossroads of podosome construction and function. J Cell Biol (2016) 0.75
RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism. Infect Immun (2016) 0.75
Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Mol Biol Cell (2017) 0.75
The roles of ARHGAP10 in the proliferation, migration and invasion of lung cancer cells. Oncol Lett (2017) 0.75
MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus. Sci Rep (2017) 0.75
ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol (2006) 7.75
Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A (2005) 5.08
Protein interaction mapping: a Drosophila case study. Genome Res (2005) 4.15
Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol (2004) 4.04
Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature (2007) 3.51
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J (2004) 3.31
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature (2007) 3.13
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. J Cell Sci (2009) 2.94
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol (2009) 2.82
Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell (2006) 2.36
Arp2/3 complex interactions and actin network turnover in lamellipodia. EMBO J (2008) 2.30
A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway. Nat Cell Biol (2008) 2.23
FMNL2 drives actin-based protrusion and migration downstream of Cdc42. Curr Biol (2012) 2.18
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol (2005) 2.16
Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments. Nat Cell Biol (2004) 2.07
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe (2009) 2.01
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci U S A (2011) 1.98
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol (2006) 1.92
RalB mobilizes the exocyst to drive cell migration. Mol Cell Biol (2006) 1.91
A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility. PLoS Biol (2010) 1.90
N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits. J Cell Sci (2005) 1.89
The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2. J Cell Sci (2008) 1.89
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Visualization and quantification of vesicle trafficking on a three-dimensional cytoskeleton network in living cells. J Microsc (2007) 1.87
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J Cell Biol (2005) 1.81
Endocytic traffic in animal cell cytokinesis. Curr Opin Cell Biol (2008) 1.80
Function and dysfunction of the PI system in membrane trafficking. EMBO J (2008) 1.75
The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130. Mol Biol Cell (2007) 1.74
The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci U S A (2006) 1.72
TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J (2004) 1.71
ER-to-Golgi carriers arise through direct en bloc protrusion and multistage maturation of specialized ER exit domains. Dev Cell (2003) 1.71
Vinculin acts as a sensor in lipid regulation of adhesion-site turnover. J Cell Sci (2005) 1.66
Filopodia: Complex models for simple rods. Int J Biochem Cell Biol (2009) 1.64
Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells. Cancer Res (2009) 1.63
Actin dynamics and turnover in cell motility. Curr Opin Cell Biol (2011) 1.59
Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development (2007) 1.57
Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J Biol Chem (2002) 1.56
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7. Curr Biol (2008) 1.55
Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc Natl Acad Sci U S A (2010) 1.54
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor. J Cell Sci (2006) 1.53
ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis. Curr Biol (2009) 1.52
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol (2003) 1.51
Sedlin controls the ER export of procollagen by regulating the Sar1 cycle. Science (2012) 1.41
The GDP-bound form of Arf6 is located at the plasma membrane. J Cell Sci (2004) 1.41
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett (2006) 1.41
RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol (2007) 1.41
Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases. Mol Biol Cell (2009) 1.40
C-terminal anchoring of mid1p to membranes stabilizes cytokinetic ring position in early mitosis in fission yeast. Mol Cell Biol (2004) 1.38
Cdc42 localization and cell polarity depend on membrane traffic. J Cell Biol (2010) 1.38
Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains. J Cell Sci (2003) 1.38
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep (2004) 1.37
The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem (2005) 1.37
A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J Cell Sci (2002) 1.35
Spatial control of cytokinesis by Cdr2 kinase and Mid1/anillin nuclear export. Curr Biol (2009) 1.35
Bacteria-host-cell interactions at the plasma membrane: stories on actin cytoskeleton subversion. Dev Cell (2005) 1.32
Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. PLoS Biol (2009) 1.32
Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells. Cancer Res (2010) 1.30
Molecular mechanism of Ena/VASP-mediated actin-filament elongation. EMBO J (2011) 1.30
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol (2013) 1.28
Lipid-transfer proteins in biosynthetic pathways. Curr Opin Cell Biol (2008) 1.26
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24
Signaling and membrane dynamics during phagocytosis: many roads lead to the phagos(R)ome. Curr Opin Cell Biol (2004) 1.24
ARF6 GTPase controls bacterial invasion by actin remodelling. J Cell Sci (2005) 1.22
A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages. Curr Biol (2005) 1.21
OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin. EMBO J (2011) 1.21
Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts. Pathogenetics (2008) 1.20
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains. J Biol Chem (2006) 1.20
Nitrate transport in plants: which gene and which control? J Exp Bot (2002) 1.17
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci (2003) 1.16
All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding. Biochem Biophys Res Commun (2008) 1.15
Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments. Biophys J (2011) 1.10
Molecular dissection of Salmonella-induced membrane ruffling versus invasion. Cell Microbiol (2009) 1.10
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation. J Cell Sci (2013) 1.08
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion. Eur J Cell Biol (2012) 1.08
GRASP65 and GRASP55 sequentially promote the transport of C-terminal valine-bearing cargos to and through the Golgi complex. J Biol Chem (2009) 1.07
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4. EMBO J (2009) 1.07
HDAC6 is required for invadopodia activity and invasion by breast tumor cells. Eur J Cell Biol (2010) 1.07
Decoupling of activation and effector binding underlies ARF6 priming of fast endocytic recycling. Curr Biol (2011) 1.07
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell (2003) 1.07
PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett (2005) 1.06
Large pleiomorphic traffic intermediates in the secretory pathway. Curr Opin Cell Biol (2005) 1.05
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport. J Biol Chem (2006) 1.04
The cellular pathway of CD1e in immature and maturing dendritic cells. Traffic (2005) 1.03
αTAT1 catalyses microtubule acetylation at clathrin-coated pits. Nature (2013) 1.03
Golgi enzymes are enriched in perforated zones of golgi cisternae but are depleted in COPI vesicles. Mol Biol Cell (2004) 1.03
Activation of a RhoA/myosin II-dependent but Arp2/3 complex-independent pathway facilitates Salmonella invasion. Cell Host Microbe (2011) 1.02
The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. Dev Cell (2012) 1.02
USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. EMBO J (2010) 1.01
The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin. J Biol Chem (2008) 1.01
Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood (2004) 1.01
EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling. Cancer Res (2006) 1.01