Published in Trends Endocrinol Metab on February 03, 2006
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04
Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol (2010) 2.22
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) (2009) 2.01
Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69
Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging (Albany NY) (2012) 1.41
Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res (2008) 1.06
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) (2012) 1.05
The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell (2010) 1.03
Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog Neurobiol (2010) 1.03
Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biol Ther (2013) 1.02
Circulating blood leukocyte gene expression profiles: effects of the Ames dwarf mutation on pathways related to immunity and inflammation. Exp Gerontol (2007) 0.84
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82
Insulin sensitivity in long-living Ames dwarf mice. Age (Dordr) (2014) 0.81
Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age. Age (Dordr) (2014) 0.79
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle. Endocrinol Metab Clin North Am (2012) 0.78
Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis. Age (Dordr) (2011) 0.78
Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection. Oxid Med Cell Longev (2015) 0.77
In active acromegaly, IGF1 bioactivity is related to soluble Klotho levels and quality of life. Endocr Connect (2014) 0.77
Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging. Aging Cell (2014) 0.77
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. PLoS One (2015) 0.77
Effects of adult onset mild calorie restriction on weight of reproductive organs, plasma parameters and gene expression in male mice. Anim Reprod (2012) 0.76
Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease. J Geriatr Cardiol (2015) 0.76
Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks. BMC Syst Biol (2016) 0.75
Renal Aging: Causes and Consequences. J Am Soc Nephrol (2016) 0.75