Published in J Gerontol A Biol Sci Med Sci on March 20, 2009
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IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity. Oncotarget (2015) 0.75
Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1. Folia Histochem Cytobiol (2015) 0.75
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Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci (2004) 2.03
Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J Endocrinol (2002) 1.94
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2004) 1.92
Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse. Exp Biol Med (Maywood) (2001) 1.64
Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology (2005) 1.45
Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab (2006) 1.23
Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse. Mech Ageing Dev (2002) 1.15
Glucose regulation and oxidative stress in healthy centenarians. Exp Gerontol (2003) 1.08
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab (2005) 2.59
Gap detection deficits in rats with tinnitus: a potential novel screening tool. Behav Neurosci (2006) 2.31
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2005) 2.28
The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry (2002) 2.17
The critical role of metabolic pathways in aging. Diabetes (2012) 2.12
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
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Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev (2009) 1.97
Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system. J Exp Biol (2008) 1.95
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Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
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Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61
Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol (2008) 1.55
Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell (2006) 1.54
Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50
Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma. Free Radic Biol Med (2007) 1.50
Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging (2005) 1.49
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Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci (2009) 1.42
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
Cochlear damage changes the distribution of vesicular glutamate transporters associated with auditory and nonauditory inputs to the cochlear nucleus. J Neurosci (2009) 1.40
Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs. J Neurosci (2005) 1.37
Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol A Biol Sci Med Sci (2009) 1.36
Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev (2006) 1.36
Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. J Gerontol A Biol Sci Med Sci (2006) 1.35
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J (2010) 1.33
Prevention of noise- and drug-induced hearing loss with D-methionine. Hear Res (2007) 1.33
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus. Hear Res (2002) 1.27
Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.25
MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell (2009) 1.24
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol (2005) 1.23
Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology (2007) 1.23
Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab (2012) 1.23
Hearing in laboratory animals: strain differences and nonauditory effects of noise. Comp Med (2005) 1.20
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Exp Eye Res (2005) 1.20
GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci (2012) 1.20
A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner? Aging (Albany NY) (2010) 1.18
Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci (2006) 1.16
PPARs in Calorie Restricted and Genetically Long-Lived Mice. PPAR Res (2007) 1.16
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
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The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Mol Endocrinol (2013) 1.11
The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs). Age (Dordr) (2012) 1.10
The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2009) 1.10
Divergent effects of caloric restriction on gene expression in normal and long-lived mice. J Gerontol A Biol Sci Med Sci (2004) 1.10
Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans? J Gerontol A Biol Sci Med Sci (2009) 1.09
Disruption of lateral efferent pathways: functional changes in auditory evoked responses. J Assoc Res Otolaryngol (2003) 1.08
Rapamycin slows aging in mice. Cell Cycle (2012) 1.08
The consequences of altered somatotropic system on reproduction. Biol Reprod (2004) 1.08
Affects of aging on receptive fields in rat primary auditory cortex layer V neurons. J Neurophysiol (2005) 1.07
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell (2009) 1.06
Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med (2009) 1.04
Play, copulation, anatomy, and testosterone in gonadally intact male rats prenatally exposed to flutamide. Physiol Behav (2003) 1.04
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
The effect of D-methionine on cochlear oxidative state with and without cisplatin administration: mechanisms of otoprotection. J Am Acad Audiol (2003) 1.02
Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology (2004) 1.02
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology (2014) 1.02
Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice. Biol Reprod (2002) 1.01
Long-living growth hormone receptor knockout mice: potential mechanisms of altered stress resistance. Exp Gerontol (2008) 1.00
Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.00
Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J Endocrinol (2013) 0.99
Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdiscip Top Gerontol (2007) 0.99
The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell (2014) 0.98
Noise induces A1 adenosine receptor expression in the chinchilla cochlea. Hear Res (2004) 0.98
Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2010) 0.97
Effects of long-term caloric restriction on glucose homeostasis and on the first steps of the insulin signaling system in skeletal muscle of normal and Ames dwarf (Prop1df/Prop1df) mice. Exp Gerontol (2005) 0.97
Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 0.97
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. Elife (2013) 0.97
Growth hormone, inflammation and aging. Pathobiol Aging Age Relat Dis (2012) 0.96
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. J Gerontol A Biol Sci Med Sci (2011) 0.95
Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice. Endocrinology (2007) 0.95
Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice. Endocrine (2003) 0.94
Sleep and temperature responses of inbred mice with Candida albicans-induced pyelonephritis. Comp Med (2006) 0.94
Early prediction of response to chemoradiotherapy for head and neck cancer: reliability of restaging with combined positron emission tomography and computed tomography. Arch Otolaryngol Head Neck Surg (2009) 0.94
Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice. Int J Biol Sci (2010) 0.94