Published in Trends Endocrinol Metab on February 03, 2006
Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci U S A (2011) 3.35
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology (2006) 2.82
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature (2013) 1.35
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol (2012) 1.32
FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy. FASEB J (2010) 1.22
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) (2012) 1.17
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Weight control and prevention of metabolic syndrome by green tea. Pharmacol Res (2010) 1.15
The UPS in diabetes and obesity. BMC Biochem (2008) 1.08
Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics (2010) 1.05
Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Mol Metab (2014) 1.03
Hepatitis C virus infection and type 1 and type 2 diabetes mellitus. World J Diabetes (2014) 0.98
Molecular mechanisms of insulin resistance in chronic hepatitis C. World J Gastroenterol (2009) 0.98
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Br J Pharmacol (2013) 0.94
Retracted Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. J Biol Chem (2014) 0.94
Insulin-stimulated glucose uptake occurs in specialized cells within the cumulus oocyte complex. Endocrinology (2012) 0.93
Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome. BMC Med Genet (2008) 0.92
Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin. J Biol Chem (2008) 0.92
Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells. Am J Physiol Cell Physiol (2010) 0.92
Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway. PLoS One (2013) 0.92
Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries. Diabetes Care (2013) 0.89
Adenovirus infection results in alterations of insulin signaling and glucose homeostasis. Am J Physiol Endocrinol Metab (2010) 0.88
Molecular targets related to inflammation and insulin resistance and potential interventions. J Biomed Biotechnol (2012) 0.88
Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele. Proc Natl Acad Sci U S A (2010) 0.87
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function. Mol Med (2012) 0.87
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells. Mol Biol Cell (2010) 0.86
The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells. Korean J Physiol Pharmacol (2014) 0.85
Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise. Am J Physiol Endocrinol Metab (2015) 0.85
Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study. Asia Pac J Clin Nutr (2013) 0.82
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes. BMC Gastroenterol (2012) 0.81
Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction. Curr Genomics (2007) 0.81
Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance. Int J Mol Med (2009) 0.80
Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells. PLoS One (2013) 0.80
Unravelling the story of protein misfolding in diabetes mellitus. World J Diabetes (2011) 0.79
Animal models of insulin resistance and heart failure. Heart Fail Rev (2014) 0.78
Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Nat Commun (2016) 0.77
Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β. Gene (2013) 0.76
Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice. Inflammation (2013) 0.76
CDK4 is an essential insulin effector in adipocytes. J Clin Invest (2015) 0.75
Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. Sci Rep (2017) 0.75
Adipose tissue characteristics related to weight z-score in childhood. Int J Endocrinol Metab (2013) 0.75
A novel myogenic function residing in the 5' non-coding region of Insulin receptor substrate-1 (Irs-1) transcript. BMC Cell Biol (2015) 0.75
The role of renal proximal tubule transport in the regulation of blood pressure. Kidney Res Clin Pract (2017) 0.75
IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco. Fish Physiol Biochem (2016) 0.75
Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women. J Assist Reprod Genet (2011) 0.75
High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling. Lipids Health Dis (2011) 0.75
Selective Insulin Resistance in the Kidney. Biomed Res Int (2016) 0.75
Species differences in regulation of renal proximal tubule transport by certain molecules. World J Nephrol (2015) 0.75
Role of insulin receptor substrates in the progression of hepatocellular carcinoma. Sci Rep (2017) 0.75
Periapical lesions decrease Akt serine phosphorylation and plasma membrane GLUT4 content in rat skeletal muscle. Clin Oral Investig (2015) 0.75
Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J (2008) 2.38
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Glucose transporter 4: cycling, compartments and controversies. EMBO Rep (2005) 1.92
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes (2007) 1.71
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology (2005) 1.64
Turning signals on and off: GLUT4 traffic in the insulin-signaling highway. Physiology (Bethesda) (2005) 1.61
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. Diabetes (2007) 1.61
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Am J Physiol Cell Physiol (2008) 1.44
Astrocytes derived from glial-restricted precursors promote spinal cord repair. J Biol (2006) 1.41
Endocytosis, recycling, and regulated exocytosis of glucose transporter 4. Biochemistry (2011) 1.38
Muscle insulin resistance: assault by lipids, cytokines and local macrophages. Curr Opin Clin Nutr Metab Care (2010) 1.38
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Proc Natl Acad Sci U S A (2010) 1.35
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Biochem Biophys Res Commun (2006) 1.35
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. J Biol Chem (2002) 1.35
Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling. Mol Endocrinol (2003) 1.33
Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling. Traffic (2008) 1.31
Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab (2012) 1.30
Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes (2010) 1.28
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle. Cell Signal (2011) 1.27
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem (2008) 1.24
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther (2008) 1.21
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). J Proteome Res (2006) 1.20
Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes (2002) 1.20
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle. Diabetes (2012) 1.16
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. J Biol Chem (2005) 1.14
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells. Arch Physiol Biochem (2009) 1.13
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. J Biol Chem (2003) 1.10
Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK. Am J Physiol Endocrinol Metab (2006) 1.07
Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. J Biol Chem (2004) 1.06
Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Mol Biol Cell (2010) 1.04
Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP. Mol Biol Cell (2004) 1.01
Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring) (2013) 1.01
Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes (2013) 1.01
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J Biol Chem (2005) 1.01
Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol Endocrinol (2012) 1.01
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells. Am J Physiol Endocrinol Metab (2008) 1.01
NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance. Endocrinology (2010) 1.00
Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε. PLoS One (2011) 1.00
A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle. Endocrinology (2008) 0.98
The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. J Cell Sci (2009) 0.98
Activation of the glucose transporter GLUT4 by insulin. Biochem Cell Biol (2002) 0.98
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol (2002) 0.98
Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells. Mol Cell Biol (2003) 0.97
Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation. Endocrinology (2011) 0.96
Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. Mol Biol Cell (2012) 0.96
Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts. J Cell Sci (2004) 0.96
Electrical stimuli release ATP to increase GLUT4 translocation and glucose uptake via PI3Kγ-Akt-AS160 in skeletal muscle cells. Diabetes (2012) 0.96
Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors. AIDS (2003) 0.93
Postmortem RNA and protein stability in perinatal human lungs. Diagn Mol Pathol (2002) 0.93
Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation. J Biol Chem (2008) 0.92
Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells. Am J Physiol Endocrinol Metab (2010) 0.92
Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes (2002) 0.91
Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells. Mol Biol Cell (2014) 0.90
TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep (2012) 0.89
Cultural differences in the visual processing of meaning: detecting incongruities between background and foreground objects using the N400. Soc Cogn Affect Neurosci (2009) 0.87
Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells. Eur J Cell Biol (2008) 0.87
Separation of oxidized variants of a monoclonal antibody by anion-exchange. J Chromatogr A (2010) 0.87
Cellular location of insulin-triggered signals and implications for glucose uptake. Pflugers Arch (2005) 0.87
GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity. Biochem J (2009) 0.87
Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis. Biosci Rep (2009) 0.86
Renal tubular apoptosis in twin-to-twin transfusion syndrome. Pediatr Dev Pathol (2003) 0.85
Antigen-specific therapeutic approaches in Type 1 diabetes. Cold Spring Harb Perspect Med (2012) 0.85
Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells. Endocrinology (2007) 0.85
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. J Biol Chem (2013) 0.85
Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant. Eur J Cell Biol (2011) 0.85
Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Diabetes (2006) 0.85
PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells. J Cell Physiol (2011) 0.83
Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers. Curr Protoc Cell Biol (2010) 0.83
Insulin elicits a ROS-activated and an IP₃-dependent Ca²⁺ release, which both impinge on GLUT4 translocation. J Cell Sci (2014) 0.82
Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation. Can J Appl Physiol (2002) 0.81
Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists. J Med Chem (2004) 0.81
Triiodothyronine acutely stimulates glucose transport into L6 muscle cells without increasing surface GLUT4, GLUT1, or GLUT3. Thyroid (2012) 0.81
Give a NOD to insulin resistance. Am J Physiol Endocrinol Metab (2011) 0.81
Meteorin reverses hypersensitivity in rat models of neuropathic pain. Exp Neurol (2012) 0.80
Reference values for second trimester fetal and neonatal organ weights and measurements. Pediatr Dev Pathol (2003) 0.80
Treatment of symptomatic osteoporosis in children: a comparison of two pamidronate dosage regimens. J Pediatr Endocrinol Metab (2011) 0.80
The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6. Endocrinology (2007) 0.79
Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. J Med Chem (2004) 0.78
Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages. Cell Commun Signal (2012) 0.78
Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on "AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress". Am J Physiol Cell Physiol (2012) 0.78
Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. J Med Chem (2005) 0.78
Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles. Bioorg Med Chem Lett (2004) 0.78
Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays. Methods Mol Biol (2008) 0.77
Muscle, liver, and pancreas: Three Musketeers fighting to control glycemia. Am J Physiol Endocrinol Metab (2006) 0.76
Putting Rac1 on the path to glucose uptake. Diabetes (2013) 0.76
Neonatal, severe primary hyperparathyroidism: a 7-year clinical and radiological follow-up of one patient. Pediatr Radiol (2002) 0.75
Insulin detemir in a twice daily insulin regimen versus a three times daily insulin regimen in the treatment of type 1 diabetes in children: A pilot randomized controlled trial. Int J Pediatr Endocrinol (2011) 0.75
Health care crisis in Gaza. CMAJ (2009) 0.75
Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award. Am J Physiol Endocrinol Metab (2007) 0.75
Corrigendum: Oligofructose as an adjunct in treatment of diabetes in NOD mice. Sci Rep (2017) 0.75