Published in Endocrinology on October 06, 2010
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J Obes (2012) 1.16
Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) (2013) 1.09
The role of gut microbiota on insulin resistance. Nutrients (2013) 0.99
Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles. Mol Biol Cell (2012) 0.96
Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance. EMBO Mol Med (2015) 0.92
TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep (2012) 0.89
Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health. World J Gastroenterol (2014) 0.86
The macrophage at the intersection of immunity and metabolism in obesity. Diabetol Metab Syndr (2011) 0.84
Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients (2013) 0.83
Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes. Gut Microbes (2016) 0.82
High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity. Am J Physiol Endocrinol Metab (2016) 0.80
Therapeutic targeting of NOD1 receptors. Br J Pharmacol (2013) 0.79
Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1. PLoS One (2014) 0.79
A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. Sci Rep (2014) 0.78
Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages. Cell Commun Signal (2012) 0.78
Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity. PLoS One (2014) 0.76
Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses. J Diabetes Res (2016) 0.76
Is immunity a mechanism contributing to statin-induced diabetes? Adipocyte (2015) 0.75
A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice. PLoS One (2017) 0.75
Skeletal muscle inflammation and atrophy in heart failure. Heart Fail Rev (2017) 0.75
Resistin increases the expression of NOD2 in mouse monocytes. Exp Ther Med (2017) 0.75
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Nod-like proteins in immunity, inflammation and disease. Nat Immunol (2006) 5.25
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
Bacterial infection causes stress-induced memory dysfunction in mice. Gut (2010) 3.06
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut (2011) 2.91
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med (2011) 2.48
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46
Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J (2008) 2.38
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity (2007) 2.15
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes (2008) 2.13
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature (2011) 2.04
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A (2011) 1.96
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Glucose transporter 4: cycling, compartments and controversies. EMBO Rep (2005) 1.92
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cell Microbiol (2009) 1.87
Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol (2012) 1.86
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol (2003) 1.79
Nod2-dependent Th2 polarization of antigen-specific immunity. J Immunol (2008) 1.78
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther (2011) 1.74
NLRC5 limits the activation of inflammatory pathways. J Immunol (2010) 1.73
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner. Immunity (2013) 1.71
The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic. Diabetes (2007) 1.71
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology (2008) 1.67
Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology (2005) 1.64
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab (2006) 1.64
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 1.62
Turning signals on and off: GLUT4 traffic in the insulin-signaling highway. Physiology (Bethesda) (2005) 1.61
Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. Diabetes (2007) 1.61
Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J (2013) 1.61
Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies. Trends Microbiol (2002) 1.59
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Am J Physiol Cell Physiol (2008) 1.44
NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol (2005) 1.42
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep (2005) 1.41
Endocytosis, recycling, and regulated exocytosis of glucose transporter 4. Biochemistry (2011) 1.38
Muscle insulin resistance: assault by lipids, cytokines and local macrophages. Curr Opin Clin Nutr Metab Care (2010) 1.38
The microbial and danger signals that activate Nod-like receptors. Cytokine (2008) 1.38
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) (2011) 1.35
Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Proc Natl Acad Sci U S A (2010) 1.35
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Biochem Biophys Res Commun (2006) 1.35
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. J Biol Chem (2002) 1.35
Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling. Mol Endocrinol (2003) 1.33
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One (2011) 1.31
Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling. Traffic (2008) 1.31
Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab (2012) 1.30
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol (2006) 1.29
Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem (2005) 1.29
Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes (2010) 1.28
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem (2005) 1.28
Therapeutic approaches for muscle wasting disorders. Pharmacol Ther (2006) 1.28
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle. Cell Signal (2011) 1.27
Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res (2012) 1.26
Innate immune sensing of microbes by Nod proteins. Ann N Y Acad Sci (2006) 1.24
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis. Proc Natl Acad Sci U S A (2008) 1.24
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem (2008) 1.24
Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway. Eur J Immunol (2007) 1.24
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther (2008) 1.21
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes (2012) 1.20
Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). J Proteome Res (2006) 1.20
Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun (2010) 1.20
Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes (2002) 1.20
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
What is new with Nods? Curr Opin Immunol (2010) 1.18
Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol (2004) 1.18
Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul Disord (2006) 1.16
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle. Diabetes (2012) 1.16
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. J Biol Chem (2005) 1.14
Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol (2011) 1.14
Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cell Microbiol (2007) 1.13
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells. Arch Physiol Biochem (2009) 1.13
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology (2012) 1.12