Published in Am J Physiol Renal Physiol on February 14, 2006
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev (2007) 6.79
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice. Am J Physiol Renal Physiol (2007) 1.99
Redox control of renal function and hypertension. Antioxid Redox Signal (2008) 1.45
Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats. Am J Physiol Renal Physiol (2009) 1.33
New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II. Peptides (2011) 1.32
Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Cell Physiol (2008) 1.28
In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice. Am J Physiol Renal Physiol (2007) 1.24
The importance of the intrarenal renin-angiotensin system. Nat Clin Pract Nephrol (2008) 1.15
Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells. Am J Physiol Cell Physiol (2007) 1.10
Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells. J Renin Angiotensin Aldosterone Syst (2007) 1.04
AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway. Am J Physiol Renal Physiol (2009) 1.04
Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin. Am J Nephrol (2011) 1.03
Proximal nephron. Compr Physiol (2013) 1.02
Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol (2010) 1.01
Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
New frontiers in the intrarenal Renin-Angiotensin system: a critical review of classical and new paradigms. Front Endocrinol (Lausanne) (2013) 0.95
Renin-angiotensin system in the kidney: What is new? World J Nephrol (2014) 0.92
Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats. Kidney Int (2011) 0.91
Novel signaling mechanisms of intracellular angiotensin II-induced NHE3 expression and activation in mouse proximal tubule cells. Am J Physiol Renal Physiol (2012) 0.91
Nebivolol attenuates maladaptive proximal tubule remodeling in transgenic rats. Am J Nephrol (2010) 0.90
Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells. Biochem Pharmacol (2006) 0.87
Effects of AT1 receptor-mediated endocytosis of extracellular Ang II on activation of nuclear factor-kappa B in proximal tubule cells. Ann N Y Acad Sci (2006) 0.86
Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. Exp Eye Res (2009) 0.85
Potential therapeutic implications of intracrine angiogenesis. Med Hypotheses (2007) 0.84
Renin-angiotensin-aldosterone system-mediated redox effects in chronic kidney disease. Transl Res (2009) 0.83
Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. J Biomed Opt (2010) 0.81
Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney. Am J Physiol Renal Physiol (2014) 0.80
Intracrine renin and angiotensin II: a novel role in cardiovascular and renal cellular regulation. J Hypertens (2006) 0.79
Decreased renal perfusion rapidly increases plasma membrane Na-K-ATPase in rat cortex by an angiotensin II-dependent mechanism. Am J Physiol Renal Physiol (2009) 0.79
Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin. Am J Physiol Renal Physiol (2014) 0.78
Physiology and Pathophysiology of the Intrarenal Renin-Angiotensin System: An Update. J Am Soc Nephrol (2017) 0.77
Urinary Angiotensinogen as a Potential Biomarker of Intrarenal Renin-angiotensin System Activity in Chinese Patients with Chronic Kidney Disease. West Indian Med J (2014) 0.76
Endocytosis. Physiol Rev (1997) 7.33
Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev (2001) 6.50
International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev (2000) 6.30
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol (2005) 4.48
Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic (2001) 2.89
Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. Hypertension (2002) 2.11
Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest (1990) 1.99
Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion. Am J Physiol (1994) 1.92
Renal injury from angiotensin II-mediated hypertension. Hypertension (1992) 1.88
Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension (2002) 1.82
Microtubules, membrane traffic, and cell organization. Cell (1990) 1.73
Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor. J Biol Chem (1998) 1.71
Proximal tubular secretion of angiotensin II in rats. Am J Physiol (1993) 1.68
Tubular transport responses to angiotensin. Am J Physiol (1985) 1.63
Intrarenal AT(1) receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol (2002) 1.59
Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. Mol Endocrinol (1997) 1.52
Angiotensin and angiotensin converting enzyme tissue levels in two-kidney, one clip hypertensive rats. Hypertension (1992) 1.52
Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens (1998) 1.47
Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol (2005) 1.45
Renal interstitial fluid angiotensin. Modulation by anesthesia, epinephrine, sodium depletion, and renin inhibition. Hypertension (1995) 1.42
Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats. J Am Soc Nephrol (1994) 1.40
Retracted Microtubules regulate angiotensin II type 1 receptor and Rac1 localization in caveolae/lipid rafts: role in redox signaling. Arterioscler Thromb Vasc Biol (2004) 1.39
Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int (2001) 1.36
Protein trafficking and polarity in kidney epithelium: from cell biology to physiology. Physiol Rev (1996) 1.34
Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol (1997) 1.29
Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors. Am J Physiol (1999) 1.27
Unraveling the Mystery of Goldblatt Hypertension. News Physiol Sci (1998) 1.20
Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells. J Biol Chem (1987) 1.19
Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci U S A (2005) 1.15
Megalin binds and internalizes angiotensin II. Am J Physiol Renal Physiol (2004) 1.13
Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney. Hypertension (1999) 1.07
Cytoskeleton-dependent endocytosis is required for apical type 1 angiotensin II receptor-mediated phospholipase C activation in cultured rat proximal tubule cells. J Clin Invest (1992) 1.05
Angiotensin II-dependent proximal tubule sodium transport requires receptor-mediated endocytosis. Am J Physiol (1994) 1.04
Receptor binding and internalization of a unique biologically active angiotensin II-colloidal gold conjugate: morphological analysis of angiotensin II processing in isolated vascular strips. J Vasc Res (1994) 1.02
The role of endogenous angiotensin II in the regulation of renal haemodynamics and proximal fluid reabsorption in the rat. J Physiol (1992) 1.01
The tubular effects of angiotensin II. Kidney Int Suppl (1987) 0.98
Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells. Eur J Cell Biol (1995) 0.98
A role for a wortmannin-sensitive phosphatidylinositol-4-kinase in the endocytosis of muscarinic cholinergic receptors. Mol Pharmacol (1998) 0.97
Angiotensin II actions in the rabbit proximal tubule. Angiotensin II mediated signaling mechanisms and electrolyte transport in the rabbit proximal tubule. Ren Physiol Biochem (1991) 0.94
High resolution localization of angiotensin II receptors in rat renal medulla. Kidney Int (1992) 0.93
Development and characterization of rabbit proximal tubular epithelial cell lines. Kidney Int (1992) 0.90
Role of internalization in AT(1A) receptor function in proximal tubule epithelium. Am J Physiol Renal Physiol (2002) 0.90
Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Hypertension (2004) 0.89
Internalization and trafficking of the human and rat growth hormone-releasing hormone receptor. J Cell Physiol (2005) 0.88
Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Am J Physiol (1995) 0.82
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev (2007) 6.79
Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production. Kidney Int (2002) 3.23
Urinary angiotensinogen as an indicator of intrarenal Angiotensin status in hypertension. Hypertension (2003) 2.99
AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension. Hypertension (2004) 2.86
Enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Hypertension (2004) 2.54
The absence of intrarenal ACE protects against hypertension. J Clin Invest (2013) 2.31
Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. Hypertension (2002) 2.11
Role of inflammation in the development of renal damage and dysfunction in angiotensin II-induced hypertension. Hypertension (2008) 2.09
Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats. Hypertension (2008) 2.01
Novel sandwich ELISA for human angiotensinogen. Am J Physiol Renal Physiol (2007) 1.99
Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients. Hypertension (2008) 1.99
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice. Am J Physiol Renal Physiol (2007) 1.99
Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension (2013) 1.98
Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery. Circ Res (2003) 1.95
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. Am J Physiol Heart Circ Physiol (2008) 1.94
Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension (2003) 1.89
Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. Am J Physiol Renal Physiol (2007) 1.87
AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats. Am J Physiol Renal Physiol (2005) 1.84
Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice. Hypertension (2009) 1.83
Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions. Am J Physiol Renal Physiol (2006) 1.83
Renal interstitial fluid concentrations of angiotensins I and II in anesthetized rats. Hypertension (2002) 1.82
Local angiotensin II aggravates cardiac remodeling in hypertension. Am J Physiol Heart Circ Physiol (2010) 1.81
ATP mediates tubuloglomerular feedback. Am J Physiol Regul Integr Comp Physiol (2002) 1.78
Angiotensin II type 1 receptor-mediated augmentation of urinary excretion of endogenous angiotensin II in Val5-angiotensin II-infused rats. Hypertension (2010) 1.67
Intrarenal AT(1) receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol (2002) 1.59
Intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increases blood pressure in rats and mice. Am J Physiol Renal Physiol (2011) 1.59
Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol (2008) 1.51
Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction. Hypertension (2003) 1.48
Heme oxygenase induction attenuates afferent arteriolar autoregulatory responses. Am J Physiol Renal Physiol (2008) 1.48
Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases. Am J Hypertens (2006) 1.46
Myocardial infarction and cardiac remodelling in mice. Exp Physiol (2002) 1.46
Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol (2005) 1.45
Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin II. Am J Physiol Renal Physiol (2010) 1.45
Connecting tubule glomerular feedback in hypertension. Hypertension (2013) 1.43
Decreased endogenous levels of Ac-SDKP promote organ fibrosis. Hypertension (2007) 1.42
Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol (2008) 1.37
Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA. Am J Physiol Renal Physiol (2008) 1.34
Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension (2002) 1.33
Augmentation of endogenous intrarenal angiotensin II levels in Val5-ANG II-infused rats. Am J Physiol Renal Physiol (2009) 1.33
Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition. Am J Physiol Renal Physiol (2009) 1.30
Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Cell Physiol (2008) 1.28
Superoxide enhances tubuloglomerular feedback by constricting the afferent arteriole. Kidney Int (2004) 1.28
Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats. Am J Physiol Renal Physiol (2011) 1.27
Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol (2005) 1.27
Angiotensin II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity. Hypertension (2011) 1.25
In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice. Am J Physiol Renal Physiol (2007) 1.24
Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition. J Am Soc Nephrol (2002) 1.24
Angiotensin-converting enzyme inhibitors: a new mechanism of action. Circulation (2005) 1.24
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP. Hypertension (2004) 1.21
Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension. Hypertension (2008) 1.20
Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats. Hypertension (2003) 1.20
AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla. Kidney Int (2009) 1.17
Possible mediators of connecting tubule glomerular feedback. Hypertension (2008) 1.16
Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension. J Hypertens (2004) 1.16
ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One (2011) 1.16
Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension (2002) 1.15
Collecting Duct Renin: A major player in Angiotensin II-dependent Hypertension. J Am Soc Hypertens (2010) 1.14
Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res (2010) 1.14
Angiotensin II type 1 receptor-mediated augmentation of renal interstitial fluid angiotensin II in angiotensin II-induced hypertension. J Hypertens (2003) 1.14
Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase. Am J Physiol Renal Physiol (2007) 1.13
Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol (2005) 1.13
Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol (2010) 1.13
Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction. J Card Fail (2005) 1.12
Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension (2012) 1.12
Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction. Hypertension (2005) 1.12
Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice. J Hypertens (2008) 1.11
Aldosterone receptor antagonism exacerbates intrarenal angiotensin II augmentation in ANG II-dependent hypertension. Am J Physiol Renal Physiol (2007) 1.11
Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice. Hypertension (2002) 1.10
Proximal tubular fluid angiotensin II levels in angiotensin II-induced hypertensive rats. J Hypertens (2003) 1.10
Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells. Am J Physiol Cell Physiol (2007) 1.10
Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension (2007) 1.10
Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2010) 1.10
Renal renin-angiotensin system. Contrib Nephrol (2004) 1.09
Cardinal role of the intrarenal renin-angiotensin system in the pathogenesis of diabetic nephropathy. J Investig Med (2013) 1.09
Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells. FASEB J (2012) 1.08
Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am J Physiol Renal Physiol (2011) 1.08
Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells. Am J Physiol Cell Physiol (2010) 1.06
N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo. Am J Physiol Heart Circ Physiol (2004) 1.06
Increased intracellular pH at the macula densa activates nNOS during tubuloglomerular feedback. Kidney Int (2005) 1.06
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. Am J Physiol Renal Physiol (2003) 1.05
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension. Am J Physiol Renal Physiol (2007) 1.05
Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol (2008) 1.04
AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway. Am J Physiol Renal Physiol (2009) 1.04
Possible role of adenosine in macula densa control of glomerular hemodynamics. Kidney Int (2002) 1.04
Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol (2007) 1.04
High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol (2010) 1.03
IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells. Mol Cell Endocrinol (2009) 1.03
Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int (2013) 1.03
Mechanism by which superoxide potentiates tubuloglomerular feedback. Hypertension (2002) 1.03
AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats. Am J Physiol Renal Physiol (2005) 1.03
Glucagon receptor-mediated extracellular signal-regulated kinase 1/2 phosphorylation in rat mesangial cells: role of protein kinase A and phospholipase C. Hypertension (2006) 1.02
Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension (2003) 1.02
Angiotensin (1-7) induces MAS receptor internalization. Hypertension (2011) 1.01
Renal nuclear angiotensin II receptors in normal and hypertensive rats. Acta Physiol Hung (2002) 1.01
Intracellular pH regulates superoxide production by the macula densa. Am J Physiol Renal Physiol (2008) 1.00
Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension (2012) 1.00
Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury. Curr Opin Nephrol Hypertens (2008) 0.99