Published in Nat Rev Mol Cell Biol on February 01, 2005
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron (2006) 4.98
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
Microglial interactions with synapses are modulated by visual experience. PLoS Biol (2010) 3.59
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Lipid-based nanotherapeutics for siRNA delivery. J Intern Med (2010) 2.15
Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol (2015) 2.08
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
The endosomal system of plants: charting new and familiar territories. Plant Physiol (2008) 2.01
Receptor-like kinases shape the plant. Nat Cell Biol (2009) 1.96
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal (2015) 1.61
Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni. Infect Immun (2006) 1.54
Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Proc Natl Acad Sci U S A (2013) 1.53
RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway. Mol Biol Cell (2007) 1.46
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol (2007) 1.40
TYK2 activity promotes ligand-induced IFNAR1 proteolysis. Biochem J (2006) 1.39
Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools. Biochem J (2006) 1.37
Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget (2012) 1.37
Cellular delivery of small interfering RNA by a non-covalently attached cell-penetrating peptide: quantitative analysis of uptake and biological effect. Nucleic Acids Res (2006) 1.36
The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. Hum Mol Genet (2009) 1.35
Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis. J Infect Dis (2011) 1.33
Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis. J Am Soc Nephrol (2009) 1.30
Lipids and lipid modifications in the regulation of membrane traffic. Curr Opin Cell Biol (2007) 1.30
Endocytic adaptors--social networking at the plasma membrane. J Cell Sci (2011) 1.29
AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases. Am J Physiol Renal Physiol (2006) 1.27
Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition. J Clin Invest (2006) 1.26
Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses. J Cell Sci (2009) 1.26
MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci (2010) 1.25
Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast. Mol Cell Biol (2006) 1.24
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol (2006) 1.23
Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2. J Biol Chem (2011) 1.22
Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett (2012) 1.21
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci (2007) 1.20
Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis. J Biol Chem (2008) 1.19
Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell (2012) 1.19
Bluetongue virus entry into cells. J Virol (2007) 1.17
COMPARTMENTS: unification and visualization of protein subcellular localization evidence. Database (Oxford) (2014) 1.16
Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Mol Cell Biol (2009) 1.15
Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol (2009) 1.15
Ubiquitin-dependent regulation of TGFbeta signaling in cancer. Neoplasia (2006) 1.14
Clustering endothelial E-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow. Blood (2007) 1.14
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem (2006) 1.13
Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain. J Biol Chem (2009) 1.12
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J (2008) 1.12
Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol (2006) 1.12
VEGFR2 translocates to the nucleus to regulate its own transcription. PLoS One (2011) 1.12
Dynamics of TGF-β/Smad signaling. FEBS Lett (2012) 1.12
Harnessing the power of the endosome to regulate neural development. Neuron (2012) 1.11
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Proc Natl Acad Sci U S A (2006) 1.10
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem (2012) 1.09
Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors. Mol Biol Cell (2006) 1.09
Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. J Cell Biol (2010) 1.09
p600, a unique protein required for membrane morphogenesis and cell survival. Proc Natl Acad Sci U S A (2005) 1.09
Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation. J Biol Chem (2008) 1.09
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2. Dev Cell (2012) 1.08
Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein. Mol Cell Biol (2007) 1.08
Endosomal crosstalk: meeting points for signaling pathways. Trends Cell Biol (2012) 1.08
Regulation of TGF-β receptor activity. Cell Biosci (2012) 1.07
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol Cell Biol (2006) 1.07
Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy. J Mol Biol (2008) 1.07
Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism. Blood (2013) 1.06
Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells. Neoplasia (2009) 1.06
Regulation of cell junction dynamics by cytokines in the testis: a molecular and biochemical perspective. Cytokine Growth Factor Rev (2007) 1.06
The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles. Plant Physiol (2011) 1.05
Regulation of VEGF signaling by membrane traffic. Cell Signal (2012) 1.04
Determination of the two-dimensional interaction rate constants of a cytokine receptor complex. Biophys J (2006) 1.04
Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates. MAbs (2012) 1.04
Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell (2006) 1.03
Caveolae-dependent endocytosis is required for class A macrophage scavenger receptor-mediated apoptosis in macrophages. J Biol Chem (2011) 1.02
Common membrane trafficking defects of disease-associated dynamin 2 mutations. Traffic (2011) 1.02
TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol (2008) 1.00
A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. Mol Cell Biol (2010) 1.00
Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry. Virology (2010) 0.99
Trafficking guidance receptors. Cold Spring Harb Perspect Biol (2010) 0.99
Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress. Oncotarget (2014) 0.99
Issues related to targeted delivery of proteins and peptides. AAPS J (2006) 0.98
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A. Blood (2008) 0.98
Modeling the signaling endosome hypothesis: why a drive to the nucleus is better than a (random) walk. Theor Biol Med Model (2005) 0.98
Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs. Biomaterials (2013) 0.98
Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell (2013) 0.97
Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res (2013) 0.97
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. J Biol Chem (2009) 0.97
Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol (2011) 0.97
Clathrin-independent pathways do not contribute significantly to endocytic flux. Elife (2014) 0.96
The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin Cancer Res (2009) 0.96
Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62. ACS Nano (2014) 0.96
Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. J Biol Chem (2008) 0.96
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. PLoS Genet (2010) 0.96
Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PLoS One (2010) 0.96
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception. Elife (2014) 0.95
SRC family kinases accelerate prolactin receptor internalization, modulating trafficking and signaling in breast cancer cells. Mol Endocrinol (2008) 0.95
Computational modeling reveals molecular details of epidermal growth factor binding. BMC Cell Biol (2005) 0.95
Promises and pitfalls of intracellular delivery of proteins. Bioconjug Chem (2014) 0.95
Baculovirus GP64-mediated entry into mammalian cells. J Virol (2011) 0.95
MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1. J Am Soc Nephrol (2011) 0.95
Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway. Lipids Health Dis (2006) 0.95
GABAA receptors, anesthetics and anticonvulsants in brain development. CNS Neurol Disord Drug Targets (2008) 0.95
Biorecognition and subcellular trafficking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Mol Pharm (2009) 0.95
Serotonergic neurons migrate radially through the neuroepithelium by dynamin-mediated somal translocation. J Neurosci (2010) 0.94
Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases. Neuropharmacology (2008) 0.93
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell (2008) 2.85
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell (2012) 2.08
Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays (2005) 1.95
The disparate role of BMP in stem cell biology. Oncogene (2005) 1.92
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
TGF-beta and the Smad signal transduction pathway. Biochem Cell Biol (2002) 1.51
Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem (2005) 1.47
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol (2007) 1.40
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol (2011) 1.23
Degradation of RhoA by Smurf1 ubiquitin ligase. Methods Enzymol (2006) 1.19
Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell (2008) 1.19
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Res (2009) 1.18
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol Cell Biol (2003) 1.15
Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep (2013) 1.15
Regulation of Par6 by extracellular signals. Curr Opin Cell Biol (2006) 1.12
Signaling and endocytosis: a team effort for cell migration. Dev Cell (2005) 1.11
SnapShot: The TGFbeta pathway interactome. Cell (2008) 1.11
Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Res (2013) 1.10
The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans. Science (2007) 1.10
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res (2011) 1.10
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity. Proc Natl Acad Sci U S A (2010) 1.08
Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. PLoS Genet (2012) 1.03
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res (2007) 1.02
Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. J Biol Chem (2008) 1.01
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorg Med Chem Lett (2011) 1.00
An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. J Biol Chem (2006) 1.00
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci (2009) 1.00
In or out? The dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol (2003) 1.00
TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. EMBO J (2011) 0.99
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med (2010) 0.98
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling. PLoS Genet (2010) 0.96
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J (2007) 0.93
Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation. Mol Cell Biol (2011) 0.92
Protein interaction networks in medicine and disease. Proteomics (2012) 0.91
Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. J Biol Chem (2004) 0.91
A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling. Mech Dev (2002) 0.90
The TGFβ superfamily in stem cell biology and early mammalian embryonic development. Biochim Biophys Acta (2012) 0.90
A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis (2008) 0.87
The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. Biochem J (2009) 0.87
Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget (2011) 0.86
No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. Cancer Res (2002) 0.85
The TGFbeta-Par6 polarity pathway: linking the Par complex to EMT and breast cancer progression. Cell Cycle (2010) 0.85
C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome. Eur J Hum Genet (2012) 0.84
Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. J Clin Invest (2016) 0.80
Structural basis for specificity of TGFβ family receptor small molecule inhibitors. Cell Signal (2011) 0.80
Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth. Cancer Res (2006) 0.78
Cell biology: an unexpected social servant. Nature (2004) 0.77
Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Mol Cell Proteomics (2013) 0.77
Structural biology: On the wings of inhibition. Nature (2002) 0.75
The return of Dr Jekyll in cancer metastasis. EMBO J (2012) 0.75
Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev (2015) 0.75