4-quinolone signalling in Pseudomonas aeruginosa: old molecules, new perspectives.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMID 16483840)

Published in Int J Med Microbiol on February 17, 2006

Authors

Stephen P Diggle1, Pierre Cornelis, Paul Williams, Miguel Cámara

Author Affiliations

1: Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK. steve.diggle@nottingham.ac.uk

Articles citing this

Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). PLoS Pathog (2009) 2.01

Evolutionary theory of bacterial quorum sensing: when is a signal not a signal? Philos Trans R Soc Lond B Biol Sci (2007) 1.69

High-resolution transcriptional analysis of the regulatory influence of cell-to-cell signalling reveals novel genes that contribute to Xanthomonas phytopathogenesis. Mol Microbiol (2013) 1.68

RhlR expression in Pseudomonas aeruginosa is modulated by the Pseudomonas quinolone signal via PhoB-dependent and -independent pathways. J Bacteriol (2006) 1.59

Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway. PLoS Pathog (2010) 1.50

Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microb Biotechnol (2008) 1.38

The pseudomonas quinolone signal (PQS) balances life and death in Pseudomonas aeruginosa populations. PLoS Pathog (2008) 1.35

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation. J Bacteriol (2008) 1.27

Gene targeting in gram-negative bacteria by use of a mobile group II intron ("Targetron") expressed from a broad-host-range vector. Appl Environ Microbiol (2007) 1.20

Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase. J Bacteriol (2009) 1.14

Full virulence of Pseudomonas aeruginosa requires OprF. Infect Immun (2010) 1.12

PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa. J Biol Chem (2008) 1.11

Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist. Microb Biotechnol (2008) 1.10

Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens. Chem Biol Drug Des (2015) 1.08

Target activation by regulatory RNAs in bacteria. FEMS Microbiol Rev (2015) 1.07

Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa. PLoS One (2011) 1.03

Chemical diversity of microbial volatiles and their potential for plant growth and productivity. Front Plant Sci (2015) 1.02

Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. Antimicrob Agents Chemother (2013) 1.00

A novel two-component system BqsS-BqsR modulates quorum sensing-dependent biofilm decay in Pseudomonas aeruginosa. Commun Integr Biol (2008) 0.98

Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. Mol Biosyst (2011) 0.97

Small RNAs and their role in biofilm formation. Trends Microbiol (2012) 0.95

Bench-to-bedside review: Quorum sensing and the role of cell-to-cell communication during invasive bacterial infection. Crit Care (2008) 0.95

Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR). PLoS Pathog (2013) 0.95

Biomolecular Mechanisms of Pseudomonas aeruginosa and Escherichia coli Biofilm Formation. Pathogens (2014) 0.95

HHQ and PQS, two Pseudomonas aeruginosa quorum-sensing molecules, down-regulate the innate immune responses through the nuclear factor-kappaB pathway. Immunology (2009) 0.94

4-Quinolones: smart phones of the microbial world. Chem Rev (2010) 0.94

MALDI-guided SIMS: multiscale imaging of metabolites in bacterial biofilms. Anal Chem (2014) 0.93

Quorum sensing modulates colony morphology through alkyl quinolones in Pseudomonas aeruginosa. BMC Microbiol (2012) 0.93

Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors. Front Microbiol (2015) 0.91

Quorum sensing in extreme environments. Life (Basel) (2013) 0.90

The quorum sensing volatile molecule 2-amino acetophenon modulates host immune responses in a manner that promotes life with unwanted guests. PLoS Pathog (2012) 0.90

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. Eur Respir J (2012) 0.89

Cross-species GacA-controlled induction of antibiosis in pseudomonads. Appl Environ Microbiol (2006) 0.87

The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol (2011) 0.86

C-type natriuretic peptide modulates quorum sensing molecule and toxin production in Pseudomonas aeruginosa. Microbiology (2011) 0.84

Attenuation of quorum sensing controlled virulence of Pseudomonas aeruginosa by cranberry. Indian J Med Res (2014) 0.83

The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J Bacteriol (2012) 0.83

Temperate phages both mediate and drive adaptive evolution in pathogen biofilms. Proc Natl Acad Sci U S A (2016) 0.83

Interference of bacterial cell-to-cell communication: a new concept of antimicrobial chemotherapy breaks antibiotic resistance. Front Microbiol (2013) 0.82

Interkingdom adenosine signal reduces Pseudomonas aeruginosa pathogenicity. Microb Biotechnol (2012) 0.80

A conserved suppressor mutation in a tryptophan auxotroph results in dysregulation of Pseudomonas quinolone signal synthesis. J Bacteriol (2014) 0.79

Volatiles in Inter-Specific Bacterial Interactions. Front Microbiol (2015) 0.79

Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence. Front Microbiol (2015) 0.79

Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa. PLoS One (2016) 0.79

Impact of storage conditions on metabolite profiles of sputum samples from persons with cystic fibrosis. J Cyst Fibros (2015) 0.79

Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1. PLoS One (2015) 0.78

A single-cell imaging screen reveals multiple effects of secreted small molecules on bacteria. Microbiologyopen (2014) 0.78

Effects of osmotic stress on rhamnolipid synthesis and time-course production of cell-to-cell signal molecules by Pseudomonas aeruginosa. Open Microbiol J (2009) 0.78

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 0.78

Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Org Lett (2013) 0.77

Environmental Burkholderia cepacia strain Cs5 acting by two analogous alkyl-quinolones and a didecyl-phthalate against a broad spectrum of phytopathogens fungi. Curr Microbiol (2011) 0.77

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies. BMC Biophys (2013) 0.76

Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264. Proc Natl Acad Sci U S A (2017) 0.76

Expression, purification, crystallization and preliminary crystallographic analysis of PA3885 (TpbA) from Pseudomonas aeruginosa PAO1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.76

Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Sci Rep (2016) 0.75

Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection. BMC Genomics (2015) 0.75

Onion Peel Ethylacetate Fraction and Its Derived Constituent Quercetin 4'-O-β-D Glucopyranoside Attenuates Quorum Sensing Regulated Virulence and Biofilm Formation. Front Microbiol (2017) 0.75

A new Pseudomonas quinolone signal (PQS) binding partner: MexG. Chem Sci (2016) 0.75

NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone. Front Microbiol (2017) 0.75

Articles by these authors

Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64

Retracted Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover. Proc Natl Acad Sci U S A (2006) 4.92

Look who's talking: communication and quorum sensing in the bacterial world. Philos Trans R Soc Lond B Biol Sci (2007) 4.24

Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med (2012) 3.51

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa. Infect Immun (2002) 3.00

The distribution of cultural and biological diversity in Africa. Proc Biol Sci (2002) 2.98

State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods. Clin Chem (2012) 2.87

The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol Microbiol (2003) 2.74

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules. Curr Opin Microbiol (2009) 2.64

LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Microbiology (2002) 2.61

Advancing the quorum in Pseudomonas aeruginosa: MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression. J Bacteriol (2002) 2.34

Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch! Curr Opin Microbiol (2002) 2.31

A global evaluation of metabolic theory as an explanation for terrestrial species richness gradients. Ecology (2007) 2.29

Positive control of swarming, rhamnolipid synthesis, and lipase production by the posttranscriptional RsmA/RsmZ system in Pseudomonas aeruginosa PAO1. J Bacteriol (2004) 2.25

The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol (2007) 2.05

Functional genetic analysis reveals a 2-Alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria. Chem Biol (2006) 2.03

The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal. Mol Microbiol (2011) 2.00

The regulation of biofilm development by quorum sensing in Aeromonas hydrophila. Environ Microbiol (2002) 1.99

Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. J Med Chem (2003) 1.94

Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology (2007) 1.88

The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82

Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: co-existence of quorum quenching and quorum sensing in Acinetobacter and Burkholderia. BMC Microbiol (2011) 1.82

Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun (2006) 1.77

Quorum sensing and social networking in the microbial world. J R Soc Interface (2009) 1.76

Quinolones: from antibiotics to autoinducers. FEMS Microbiol Rev (2011) 1.75

Pseudomonas aeruginosa displays an epidemic population structure. Environ Microbiol (2002) 1.73

Molecular epidemiology of Pseudomonas aeruginosa colonization in a burn unit: persistence of a multidrug-resistant clone and a silver sulfadiazine-resistant clone. J Clin Microbiol (2003) 1.70

Genomics of pyoverdine-mediated iron uptake in pseudomonads. Trends Microbiol (2003) 1.70

Evolutionary theory of bacterial quorum sensing: when is a signal not a signal? Philos Trans R Soc Lond B Biol Sci (2007) 1.69

Pseudomonas aeruginosa population structure revisited. PLoS One (2009) 1.68

LuxS and autoinducer-2: their contribution to quorum sensing and metabolism in bacteria. Adv Appl Microbiol (2003) 1.68

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology (2012) 1.68

Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS Microbiol Lett (2002) 1.65

Bacterial conversations: talking, listening and eavesdropping. An introduction. Philos Trans R Soc Lond B Biol Sci (2007) 1.64

Setting targets for universal access to HIV prevention, treatment and care for injecting drug users (IDUs): towards consensus and improved guidance. Int J Drug Policy (2008) 1.64

Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium. Microbiology (2002) 1.59

Analysis of the Pseudomonas aeruginosa oprD gene from clinical and environmental isolates. Environ Microbiol (2002) 1.57

The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Environ Microbiol (2006) 1.56

High throughput methods applied in biomaterial development and discovery. Biomaterials (2009) 1.52

Working alliance and its relationship to outcomes in a randomized controlled trial (RCT) of antipsychotic medication. BMC Psychiatry (2013) 1.50

The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling. Environ Microbiol (2011) 1.48

Quorum-sensing and cheating in bacterial biofilms. Proc Biol Sci (2012) 1.47

Pseudomonas aeruginosa fosfomycin resistance mechanisms affect non-inherited fluoroquinolone tolerance. J Med Microbiol (2011) 1.46

Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori. Mol Microbiol (2004) 1.45

Global Pseudomonas aeruginosa biodiversity as reflected in a Belgian river. Environ Microbiol (2005) 1.45

Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS. Anal Bioanal Chem (2010) 1.45

Decision aid on disclosure of mental health status to an employer: feasibility and outcomes of a randomised controlled trial. Br J Psychiatry (2013) 1.45

Cell-to-cell communication across the prokaryote-eukaryote boundary. Science (2002) 1.45

Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicol Teratol (2009) 1.44

The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology (2005) 1.43

Spite and virulence in the bacterium Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2009) 1.43

LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence. Microbiology (2002) 1.43

VanT, a homologue of Vibrio harveyi LuxR, regulates serine, metalloprotease, pigment, and biofilm production in Vibrio anguillarum. J Bacteriol (2002) 1.43

A cell-cell communication signal integrates quorum sensing and stress response. Nat Chem Biol (2013) 1.41

Reiterative justice? Sci Justice (2004) 1.38

Icodextrin improves the fluid status of peritoneal dialysis patients: results of a double-blind randomized controlled trial. J Am Soc Nephrol (2003) 1.38

NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem (2007) 1.37

Controlling infection by tuning in and turning down the volume of bacterial small-talk. Lancet Infect Dis (2002) 1.36

The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescens. Mol Microbiol (2002) 1.36

N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology (2005) 1.35

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus. Infect Immun (2006) 1.35

Phylogenetic analysis of intestinal microflora indicates a novel Mycoplasma phylotype in farmed and wild salmon. Microb Ecol (2002) 1.35

Inhibition and dispersion of Pseudomonas aeruginosa biofilms by glycopeptide dendrimers targeting the fucose-specific lectin LecB. Chem Biol (2008) 1.34

Identification of new, conserved, non-ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine. Mol Microbiol (2002) 1.34

The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. Mol Microbiol (2004) 1.33

Biofilm formation in Pseudomonas aeruginosa: fimbrial cup gene clusters are controlled by the transcriptional regulator MvaT. J Bacteriol (2004) 1.32

Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system. J Infect Dis (2012) 1.32

The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system. Infect Immun (2002) 1.29

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa. Microbiology (2004) 1.27

Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing. J Bacteriol (2006) 1.27

Pyocin S2 (Sa) kills Pseudomonas aeruginosa strains via the FpvA type I ferripyoverdine receptor. J Bacteriol (2007) 1.26

Conservation, surface exposure, and in vivo expression of the Frp family of iron-regulated cell wall proteins in Staphylococcus aureus. Infect Immun (2002) 1.25

Differential immune modulatory activity of Pseudomonas aeruginosa quorum-sensing signal molecules. Infect Immun (2004) 1.25

Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum. Hum Mol Genet (2009) 1.24

Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC. J Mol Biol (2008) 1.23

Predicting the virulence of MRSA from its genome sequence. Genome Res (2014) 1.23