PubRank

Rose Hurren

Author PubWeight™ 36.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 2011 2.68
2 Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood 2009 1.99
3 Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells. J Immunol 2003 1.72
4 The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 2010 1.24
5 A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther 2008 1.21
6 Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Res 2009 1.18
7 Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Res 2008 1.17
8 Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. Cancer Res 2011 1.13
9 The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood 2010 1.11
10 Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer Res 2006 1.11
11 A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood 2010 1.09
12 Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood 2008 1.08
13 Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J Clin Invest 2012 1.04
14 A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin. Blood 2007 1.03
15 Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther 2010 1.03
16 A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res 2007 1.02
17 Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. J Natl Cancer Inst 2007 0.97
18 Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies. Am J Hematol 2014 0.95
19 The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. Mol Pharmacol 2011 0.92
20 NKG2D splice variants: a reexamination of adaptor molecule associations. Immunogenetics 2006 0.92
21 Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid. Apoptosis 2006 0.90
22 Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. J Clin Endocrinol Metab 2008 0.87
23 Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells. Chem Biol 2011 0.87
24 Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget 2011 0.86
25 The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood 2010 0.85
26 Expression cloning and function of the rat NK activating and inhibitory receptors NKR-P1A and -P1B. Int Immunol 2003 0.84
27 Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism. PLoS One 2013 0.83
28 A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. Apoptosis 2012 0.81
29 Suppression of cancer progression by MGAT1 shRNA knockdown. PLoS One 2012 0.81
30 Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells. PLoS One 2013 0.80
31 Dexamethasone increases ubiquitin transcription through an SP-1 dependent mechanism in multiple myeloma cells. Leuk Res 2008 0.79
32 Survival versus neglect: redefining thymocyte subsets based on expression of NKG2D ligand(s) and MHC class I. Eur J Immunol 2005 0.79
33 Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells. Apoptosis 2015 0.76
34 Mitochondrial DNA damage by bleomycin induces AML cell death. Apoptosis 2015 0.76
35 Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis 2015 0.75
36 Immunosynapse formation coincides with rapid activation of NK cells by syngeneic T cells and correlates with clustering of MHC class I. Int Immunol 2005 0.75