Published in J Immunol on March 01, 2006
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest (2009) 2.26
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells. Int Immunol (2009) 2.10
Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas. PLoS One (2013) 1.44
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biol Blood Marrow Transplant (2010) 1.38
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
The epigenetic landscape of T cell exhaustion. Science (2016) 1.31
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proc Natl Acad Sci U S A (2007) 1.28
Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway. J Immunol (2008) 1.27
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol (2012) 1.23
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway. Aging Cell (2010) 1.12
Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol (2008) 1.10
Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma. Transl Oncol (2013) 1.08
Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C. World J Gastroenterol (2009) 1.07
Tim-3 expression defines regulatory T cells in human tumors. PLoS One (2013) 1.02
Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-γ producing T cells. PLoS One (2012) 0.97
The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol (2012) 0.95
Expression and function of PDCD1 at the human maternal-fetal interface. Biol Reprod (2008) 0.93
T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med (2008) 0.93
Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis. Clin Dev Immunol (2011) 0.92
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol (2012) 0.91
Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells. Virology (2009) 0.88
T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment. J Hematol Oncol (2015) 0.86
Expression of PD-1 Molecule on Regulatory T Lymphocytes in Patients with Insulin-Dependent Diabetes Mellitus. Int J Mol Sci (2015) 0.86
Phenotypical characterization of regulatory T cells in humans and rodents. Clin Exp Immunol (2016) 0.86
Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. Hum Immunol (2009) 0.85
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res (2015) 0.84
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity. J Invest Dermatol (2010) 0.84
High proportions of regulatory B and T cells are associated with decreased cellular responses to pH1N1 influenza vaccine in HIV-infected children and youth (IMPAACT P1088). Hum Vaccin Immunother (2013) 0.84
PD-1 regulates extrathymic regulatory T-cell differentiation. Eur J Immunol (2014) 0.83
Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration. J Immunol (2011) 0.83
Unexpected acceleration of type 1 diabetes by transgenic expression of B7-H1 in NOD mouse peri-islet glia. Diabetes (2010) 0.83
Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation. Front Immunol (2014) 0.83
Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications. PLoS Negl Trop Dis (2013) 0.82
Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma. Am J Pathol (2010) 0.82
Immune correlates of herpes zoster in HIV-infected children and youth. J Virol (2011) 0.82
Inhibitors of B7-CD28 costimulation in urologic malignancies. Immunotherapy (2009) 0.77
Promises and paradoxes of regulatory T cells in inflammatory bowel disease. World J Gastroenterol (2015) 0.77
Effects of lung cancer cell-associated B7-H1 on T-cell proliferation in vitro and in vivo. Braz J Med Biol Res (2016) 0.75
Role of TIM-3 in ovarian cancer. Clin Transl Oncol (2017) 0.75
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood (2011) 5.82
Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol (2007) 4.29
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood (2004) 3.68
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol (2007) 2.61
Human placental trophoblasts confer viral resistance to recipient cells. Proc Natl Acad Sci U S A (2013) 2.42
Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol (2004) 2.38
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant (2005) 2.32
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 2.12
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood (2002) 2.02
Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell (2012) 1.99
High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation (2008) 1.85
Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol (2008) 1.77
IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol (2011) 1.72
What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol (2007) 1.64
Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev (2003) 1.61
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood (2002) 1.53
CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells. J Immunol (2005) 1.52
Tolerogenic plasmacytoid DC. Eur J Immunol (2010) 1.48
Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. Blood (2013) 1.48
mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood (2010) 1.45
Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. Blood (2003) 1.43
Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol (2008) 1.39
Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther (2005) 1.38
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am J Transplant (2005) 1.32
Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol (2002) 1.32
Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol (2013) 1.30
Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol (2007) 1.30
"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol (2006) 1.30
Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival. Am J Transplant (2005) 1.26
Tolerogenic dendritic cells and their role in transplantation. Semin Immunol (2011) 1.26
Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol (2010) 1.24
Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes (2012) 1.22
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol (2008) 1.22
Dendritic cells: key to fetal tolerance? Biol Reprod (2007) 1.21
Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant (2003) 1.21
Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection. Clin Immunol (2002) 1.17
Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. Hepatology (2004) 1.16
Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses. J Immunol (2009) 1.16
Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood (2010) 1.14
Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol (2005) 1.14
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation (2007) 1.10
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol (2007) 1.10
Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol (2008) 1.10
Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J Leukoc Biol (2006) 1.09
Dendritic cells, the liver, and transplantation. Hepatology (2007) 1.09
Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. Am J Transplant (2005) 1.09
Dendritic cells under the spell of prostaglandins. Trends Immunol (2003) 1.08
Naturally occurring regulatory T cells: recent insights in health and disease. Crit Rev Immunol (2007) 1.08
Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts. J Immunol (2002) 1.07
Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity. Blood (2012) 1.06
IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. J Immunol (2012) 1.06
Regulatory dendritic cell therapy in organ transplantation. Transpl Int (2006) 1.06
Suppression of autoimmune diabetes by soluble galectin-1. J Immunol (2009) 1.06
Antigen-presenting cells and materno-fetal tolerance: an emerging role for dendritic cells. Am J Reprod Immunol (2007) 1.05
Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion. Transpl Immunol (2007) 1.05
Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol (2005) 1.04
Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest (2016) 1.03
Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. Hepatology (2008) 1.03
Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation (2014) 1.01
Methods of analysis of dendritic cell-derived exosome-shuttle microRNA and its horizontal propagation between dendritic cells. Methods Mol Biol (2013) 1.00
Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease. Transplantation (2002) 1.00
Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. Transplantation (2006) 0.99
NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation. J Immunol (2009) 0.99
Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury. J Am Soc Nephrol (2012) 0.99
In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival. Transplantation (2004) 0.98
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol (2006) 0.98
In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy. PLoS One (2009) 0.97
Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. J Leukoc Biol (2011) 0.97
Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses. Eur J Immunol (2006) 0.97
Influence of immunosuppressive drugs on dendritic cells. Transpl Immunol (2003) 0.96
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol (2012) 0.96
Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. Transplantation (2008) 0.95
Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation. Transplantation (2007) 0.95