Published in Dev Biol on February 21, 2006
Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell (2010) 4.78
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
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Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
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An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol (2008) 1.78
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol (2007) 1.74
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One (2008) 1.63
Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2010) 1.59
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FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia. BMC Dev Biol (2008) 1.26
Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development (2011) 1.19
Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate. Dev Biol (2009) 1.13
FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn (2009) 1.11
The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol (2011) 1.07
Wnt signaling in lung organogenesis. Organogenesis (2008) 1.06
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development (2011) 1.04
Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J Biol Chem (2008) 1.03
Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation. Methods Mol Biol (2010) 1.02
Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in un-immunosuppressed mouse retina. Mol Vis (2012) 1.02
Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res (2009) 1.00
Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol (2012) 0.99
Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn (2009) 0.97
Signaling networks regulating development of the lower respiratory tract. Cold Spring Harb Perspect Biol (2012) 0.97
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol (2010) 0.94
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. Mol Cell Biol (2009) 0.94
Conditional hypoxia inducible factor-1α induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol (2011) 0.92
Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer Res (2013) 0.91
Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn (2011) 0.90
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2011) 0.89
Mechanisms of bronchopulmonary dysplasia. J Cell Commun Signal (2013) 0.88
Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis. Mech Dev (2015) 0.87
A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne) (2015) 0.85
Structure and epitope distribution of heparan sulfate is disrupted in experimental lung hypoplasia: a glycobiological epigenetic cause for malformation? BMC Dev Biol (2011) 0.82
Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development. Dev Dyn (2014) 0.82
Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching. J Vis Exp (2010) 0.82
Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury. Scientifica (Cairo) (2014) 0.81
FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell (2015) 0.81
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis. Biol Open (2012) 0.81
Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci (2012) 0.81
Comparative molecular developmental aspects of the mammalian- and the avian lungs, and the insectan tracheal system by branching morphogenesis: recent advances and future directions. Front Zool (2012) 0.79
Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma. PLoS Genet (2015) 0.79
Genetic insights into the mechanisms of Fgf signaling. Genes Dev (2016) 0.79
Centrifugal migration of mesenchymal cells in embryonic lung. Dev Dyn (2008) 0.78
Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung. Pathobiology (2012) 0.76
Expression of FGFs during early mouse tongue development. Gene Expr Patterns (2015) 0.75
Dynamic transcriptional signatures and network responses for clinical symptoms in influenza-infected human subjects using systems biology approaches. J Pharmacokinet Pharmacodyn (2014) 0.75
Three-dimensional culture and FGF signaling drive differentiation of murine pluripotent cells to distal lung epithelial cells. Stem Cells Dev (2015) 0.75
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol (2007) 3.33
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83
Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell (2003) 2.70
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J (2007) 2.57
Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol (2005) 2.23
Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res (2005) 1.97
Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development (2005) 1.88
VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol (2005) 1.81
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol (2007) 1.74
Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase. Pediatr Res (2003) 1.74
Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc (2011) 1.66
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol (2009) 1.65
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One (2008) 1.63
Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2010) 1.59
Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol (2004) 1.56
miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol (2009) 1.56
Fibrillin controls TGF-beta activation. Nat Genet (2003) 1.53
Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol (2003) 1.53
Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development (2006) 1.49
Lung development and adult lung diseases. Chest (2007) 1.47
Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells (2008) 1.46
Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev Biol (2008) 1.46
Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One (2010) 1.44
Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.42
Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest (2011) 1.38
Developmental biology: order in the lung. Nature (2008) 1.36
Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology (2007) 1.30
Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg (2005) 1.28
Development, repair and fibrosis: what is common and why it matters. Respirology (2009) 1.24
Next stop, the twilight zone: hedgehog network regulation of mammary gland development. J Mammary Gland Biol Neoplasia (2004) 1.20
Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res (2003) 1.20
Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One (2011) 1.20
TACE is required for fetal murine cardiac development and modeling. Dev Biol (2003) 1.19
A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development (2011) 1.18
Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol (2006) 1.15
MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cells. PLoS One (2012) 1.13
Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol (2008) 1.13
Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway. Mech Dev (2007) 1.13
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med (2009) 1.12
Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. J Pediatr Surg (2004) 1.11
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol (2007) 1.11
Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol (2004) 1.11
The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem (2012) 1.10
Smad3 signaling involved in pulmonary fibrosis and emphysema. Proc Am Thorac Soc (2006) 1.09
The human gamma-glutamyltransferase gene family. Hum Genet (2008) 1.08
BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. J Biol Chem (2006) 1.07
Mammary glands and feathers: comparing two skin appendages which help define novel classes during vertebrate evolution. Semin Cell Dev Biol (2007) 1.06
Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development (2011) 1.04
Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One (2012) 1.04
Human tissue-engineered small intestine forms from postnatal progenitor cells. J Pediatr Surg (2013) 1.04
The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. J Pediatr Surg (2006) 1.03
FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development (2010) 1.03
Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet (2010) 1.03
Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation. Methods Mol Biol (2010) 1.02
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med (2009) 1.01
Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. J Physiol (2009) 1.01
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene (2007) 1.00
Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol (2006) 1.00
Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res (2009) 1.00
Branching patterns emerge in a mathematical model of the dynamics of lung development. J Physiol (2013) 1.00
Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. J Physiol (2008) 0.99
Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol (2012) 0.98
Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol (2010) 0.98
Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol (2007) 0.97
Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol (2013) 0.95
Fibroblast growth factor-10 serves a regulatory role in duodenal development. J Pediatr Surg (2005) 0.95
A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev Biol (2005) 0.95
Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol (2010) 0.92
Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS One (2012) 0.92
Laparoscopic versus open treatment of congenital duodenal obstruction: multicenter short-term outcomes analysis. J Laparoendosc Adv Surg Tech A (2013) 0.92
Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc (2009) 0.91
Knock-on effect of anthrax lethal toxin on macrophages potentiates cytotoxicity to endothelial cells. Microbes Infect (2004) 0.91
High-resolution association mapping of number of teats in pigs reveals regions controlling vertebral development. BMC Genomics (2014) 0.91
Tissue engineering of the intestine in a murine model. J Vis Exp (2012) 0.90
The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol (2011) 0.90
Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn (2011) 0.90
Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol (2011) 0.89
Functional analysis of the human Sprouty2 gene promoter. Gene (2003) 0.89
Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. J Pediatr Surg (2002) 0.88
Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha. Biochem Biophys Res Commun (2008) 0.87
Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol (2009) 0.87