Published in Am J Physiol Gastrointest Liver Physiol on February 23, 2006
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem (2008) 3.08
Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28
Reactive oxygen species scavenger N-acetyl cysteine reduces methamphetamine-induced hyperthermia without affecting motor activity in mice. Temperature (Austin) (2015) 1.52
S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance. Circ Res (2008) 1.34
Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal (2009) 1.18
Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. Am J Physiol Endocrinol Metab (2009) 1.05
Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol (2008) 1.01
Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal (2011) 1.01
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem (2011) 0.98
The energy-redox axis in aging and age-related neurodegeneration. Adv Drug Deliv Rev (2009) 0.98
A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol (2011) 0.94
Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol (2010) 0.94
Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis. Anal Biochem (2008) 0.94
Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity. Antioxid Redox Signal (2011) 0.94
Curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex I activity, and membrane permeability transition pore opening. Evid Based Complement Alternat Med (2013) 0.92
Profiling the reactive metabolites of xenobiotics using metabolomic technologies. Chem Res Toxicol (2011) 0.92
Molecular mechanisms underlying chemical liver injury. Expert Rev Mol Med (2012) 0.91
Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency. Exp Biol Med (Maywood) (2012) 0.89
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (2012) 0.89
Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats. Int J Mol Sci (2012) 0.88
Glutathiolated Ras: characterization and implications for Ras activation. Free Radic Biol Med (2012) 0.86
Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver. Antioxid Redox Signal (2014) 0.84
Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells. Am J Physiol Cell Physiol (2010) 0.84
Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery. Biochim Biophys Acta (2011) 0.84
Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis. Am J Physiol Gastrointest Liver Physiol (2010) 0.84
Oxidative stress promotes D-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity. Inflamm Res (2014) 0.82
Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism. J Zhejiang Univ Sci B (2014) 0.82
Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther (2012) 0.82
Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int (2010) 0.82
Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress. Oxid Med Cell Longev (2016) 0.81
Effects of seasonal and latitudinal cold on oxidative stress parameters and activation of hypoxia inducible factor (HIF-1) in zoarcid fish. J Comp Physiol B (2007) 0.81
Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation. Sultan Qaboos Univ Med J (2016) 0.80
Effects of acute exercise on liver function and blood redox status in heavy drinkers. Exp Ther Med (2015) 0.80
Predicting the Kinetic Properties Associated with Redox Imbalance after Oxidative Crisis in G6PD-Deficient Erythrocytes: A Simulation Study. Adv Hematol (2011) 0.78
Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. Antioxid Redox Signal (2015) 0.77
Oxidised- and total non-protein bound glutathione and related thiols in gallbladder bile of patients with various gastrointestinal disorders. BMC Gastroenterol (2007) 0.77
N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcohol Clin Exp Res (2014) 0.76
Redox imaging of inflammation in asthma. Am J Respir Crit Care Med (2014) 0.76
The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2). Toxicol Appl Pharmacol (2016) 0.75
The Cooperative Effect of Local Angiotensin-II in Liver with Adriamycin Hepatotoxicity on Mitochondria. Med Sci Monit (2016) 0.75
Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model. BMC Gastroenterol (2014) 0.75
Inhibition of Hepatic Ischemic Reperfusion Injury Using Saline Exposed to Electron Discharge in a Rat Model. Cell Med (2013) 0.75
Liver Effects of Clinical Drugs Differentiated in Human Liver Slices. Int J Mol Sci (2017) 0.75
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology (2006) 3.76
Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology (2006) 3.70
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA (2006) 3.49
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology (2003) 3.18
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem (2008) 3.08
Clinical risk factors for portopulmonary hypertension. Hepatology (2008) 2.62
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology (2004) 2.26
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology (2006) 2.12
Drug-induced liver injury. Drug Saf (2007) 1.99
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol (2006) 1.89
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology (2003) 1.72
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol (2004) 1.68
Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol (2003) 1.62
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol (2013) 1.61
ER stress: can the liver cope? J Hepatol (2006) 1.58
c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem (2011) 1.57
Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med (2008) 1.55
Serum alanine aminotransferase in skeletal muscle diseases. Hepatology (2005) 1.54
Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol (2005) 1.54
Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology (2004) 1.51
Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology (2008) 1.50
The contribution of endoplasmic reticulum stress to liver diseases. Hepatology (2011) 1.50
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr (2007) 1.49
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res (2005) 1.49
Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med (2009) 1.44
Immune-mediated drug-induced liver disease. Clin Liver Dis (2002) 1.38
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology (2009) 1.35
Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2006) 1.35
Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology (2004) 1.31
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology (2011) 1.23
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem (2010) 1.20
Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology (2003) 1.19
Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal (2009) 1.18
Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol (2006) 1.17
Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol (2010) 1.16
Mechanisms of drug-induced liver disease. Clin Liver Dis (2007) 1.15
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology (2003) 1.14
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology (2002) 1.13
Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol (2005) 1.12
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med (2006) 1.11
Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11
Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 1.10
Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology (2010) 1.08
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci (2013) 1.07
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology (2007) 1.05
Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev (2004) 1.05
Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf (2003) 1.03
Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol (2008) 1.01
Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res (2010) 1.00
Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv (2010) 1.00
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem (2012) 0.99
Mechanisms of drug-induced liver injury. Clin Liver Dis (2013) 0.99
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem (2011) 0.98
Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol (2004) 0.98
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem (2007) 0.97
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res (2008) 0.97
Avoiding idiosyncratic DILI: two is better than one. Hepatology (2013) 0.93
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol (2012) 0.93
Current challenges and controversies in drug-induced liver injury. Drug Saf (2012) 0.90
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (2012) 0.89
The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf (2014) 0.87
Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol (2004) 0.87
How to protect against acetaminophen: don't ask for JUNK. Gastroenterology (2008) 0.87
Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf (2014) 0.86
Drug hepatotoxicity. Clin Liver Dis (2006) 0.86
Differential effect of gender on hepatic fat. Pediatr Radiol (2011) 0.83
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol (2014) 0.82
Carcinosarcoma of the liver. Intern Med (2010) 0.80
Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A (2012) 0.79
Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics (2011) 0.78
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol (2003) 0.78
Implications of Treating Hepatitis C Virus Infection Among Patients Awaiting Cadaveric Liver Transplant: A Single-Center Experience. Exp Clin Transplant (2015) 0.77
A murder mystery in the liver: who done it and how? J Clin Invest (2016) 0.76
Did this drug cause my patient's hepatitis? Ann Intern Med (2003) 0.75
Liver injury associated with the beta-interferons for MS. Neurology (2004) 0.75
The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol (2002) 0.75
Statin-induced hepatotoxicity. Gastroenterology (2004) 0.75
Isolated arterioportal fistula presenting with variceal hemorrhage. World J Gastroenterol (2013) 0.75
Pre- Versus Posttransplant Treatment of Hepatitis C Virus With Direct-Acting Antivirals in Liver Transplant Recipients: More Issues to be Solved. Exp Clin Transplant (2017) 0.75
Microvascular Invasion in Hepatocellular Carcinoma and Liver Transplant. Exp Clin Transplant (2016) 0.75