Published in Hepatology on August 01, 2004
Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology (2011) 5.06
Cellular and molecular mechanisms of liver injury. Gastroenterology (2008) 3.02
Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology (2008) 1.90
Alcohol and lipid metabolism. Am J Physiol Endocrinol Metab (2008) 1.79
Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res (2008) 1.59
Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol (2008) 1.59
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J Nutr Biochem (2008) 1.52
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res (2005) 1.49
Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology (2005) 1.45
Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nat Nanotechnol (2013) 1.23
Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal (2009) 1.18
Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem Res Int (2011) 1.14
Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med (2005) 1.08
Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology (2010) 1.08
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology (2007) 1.05
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res (2008) 0.97
Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats. Alcohol Clin Exp Res (2011) 0.94
Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes. Hepatology (2012) 0.93
Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin Exp Res (2011) 0.91
Hepatic stellate cells and innate immunity in alcoholic liver disease. World J Gastroenterol (2011) 0.89
Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflamm Res (2010) 0.89
TLRs, Alcohol, HCV, and Tumorigenesis. Gastroenterol Res Pract (2011) 0.88
Endoplasmic Reticulum Stress and Associated ROS. Int J Mol Sci (2016) 0.86
Role of transmethylation reactions in alcoholic liver disease. World J Gastroenterol (2007) 0.85
Barley Sprouts Extract Attenuates Alcoholic Fatty Liver Injury in Mice by Reducing Inflammatory Response. Nutrients (2016) 0.79
Involvement of hepatic innate immunity in alcoholic liver disease. Immune Netw (2010) 0.78
New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep (2014) 0.76
Pathogenesis and Management of Alcoholic Liver Disease. Dig Dis (2016) 0.76
Emerging concepts in alcoholic hepatitis. World J Hepatol (2017) 0.75
Degenerative liver disease in young Beagles with hereditary cobalamin malabsorption because of a mutation in the cubilin gene. J Vet Intern Med (2014) 0.75
Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism. Alcohol Clin Exp Res (2016) 0.75
Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice. Evid Based Complement Alternat Med (2015) 0.75
Biermer's anemia: a new cause of cholestasis and hepatic steatosis? Dig Dis Sci (2007) 0.75
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology (2006) 3.76
Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology (2006) 3.70
Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA (2006) 3.49
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology (2003) 3.18
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem (2008) 3.08
Clinical risk factors for portopulmonary hypertension. Hepatology (2008) 2.62
Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology (2004) 2.26
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology (2006) 2.12
Drug-induced liver injury. Drug Saf (2007) 1.99
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol (2006) 1.89
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology (2003) 1.72
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol (2004) 1.68
Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol (2003) 1.62
Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol (2006) 1.62
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol (2013) 1.61
ER stress: can the liver cope? J Hepatol (2006) 1.58
c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem (2011) 1.57
Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med (2008) 1.55
Serum alanine aminotransferase in skeletal muscle diseases. Hepatology (2005) 1.54
Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol (2005) 1.54
Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology (2004) 1.51
Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology (2008) 1.50
The contribution of endoplasmic reticulum stress to liver diseases. Hepatology (2011) 1.50
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr (2007) 1.49
Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res (2005) 1.49
Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med (2009) 1.44
Immune-mediated drug-induced liver disease. Clin Liver Dis (2002) 1.38
Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem (2010) 1.37
Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology (2009) 1.35
Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2006) 1.35
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology (2011) 1.23
Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology (2004) 1.21
Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem (2010) 1.20
Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology (2003) 1.19
Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal (2009) 1.18
Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol (2006) 1.17
Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol (2010) 1.16
Mechanisms of drug-induced liver disease. Clin Liver Dis (2007) 1.15
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology (2003) 1.14
Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology (2002) 1.13
Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol (2005) 1.12
Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med (2006) 1.11
Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 1.10
Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology (2010) 1.08
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci (2013) 1.07
A novel role of miR-302/367 in reprogramming. Biochem Biophys Res Commun (2011) 1.06
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology (2007) 1.05
Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev (2004) 1.05
Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf (2003) 1.03
Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol (2008) 1.01
Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res (2010) 1.00
Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv (2010) 1.00
Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem (2012) 0.99
Mechanisms of drug-induced liver injury. Clin Liver Dis (2013) 0.99
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem (2011) 0.98
Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol (2004) 0.98
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem (2007) 0.97
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res (2008) 0.97
Avoiding idiosyncratic DILI: two is better than one. Hepatology (2013) 0.93
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol (2012) 0.93
Current challenges and controversies in drug-induced liver injury. Drug Saf (2012) 0.90
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (2012) 0.89
The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf (2014) 0.87
Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol (2004) 0.87
How to protect against acetaminophen: don't ask for JUNK. Gastroenterology (2008) 0.87
MiRNA targets of prostate cancer. Methods Mol Biol (2013) 0.86
Drug hepatotoxicity. Clin Liver Dis (2006) 0.86
Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf (2014) 0.86
Differential effect of gender on hepatic fat. Pediatr Radiol (2011) 0.83
Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol (2014) 0.82
Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas (2009) 0.80
Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A (2012) 0.79
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol (2003) 0.78
Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics (2011) 0.78
A murder mystery in the liver: who done it and how? J Clin Invest (2016) 0.76
The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol (2002) 0.75
Statin-induced hepatotoxicity. Gastroenterology (2004) 0.75
Did this drug cause my patient's hepatitis? Ann Intern Med (2003) 0.75
Liver injury associated with the beta-interferons for MS. Neurology (2004) 0.75
Unilateral skill acquisition induces bilateral NMDA receptor subunit composition shifts in the rat sensorimotor striatum. Brain Res (2013) 0.75