Published in Diabetes on March 01, 2006
Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71
Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis. Diabetes (2010) 1.25
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. Am J Physiol Endocrinol Metab (2009) 1.19
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) (2012) 1.17
Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PLoS One (2012) 1.15
Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. Diabetes (2013) 1.10
The UPS in diabetes and obesity. BMC Biochem (2008) 1.08
Retracted Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. J Biol Chem (2014) 0.94
Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Mol Metab (2014) 0.89
Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity. Endocrinology (2015) 0.87
Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target. Br J Pharmacol (2015) 0.86
Molecular mechanisms of insulin resistance in chronic kidney disease. Kidney Int (2015) 0.82
Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key? J Pharmacol Exp Ther (2012) 0.79
Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin. Front Endocrinol (Lausanne) (2013) 0.75
Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance. PLoS One (2015) 0.75
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol (2002) 4.94
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes (2006) 4.14
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem (2005) 3.04
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab (2007) 2.63
Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci U S A (2009) 2.60
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab (2010) 2.44
Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. J Clin Invest (2012) 2.38
Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. J Clin Endocrinol Metab (2007) 2.20
IRS1-independent defects define major nodes of insulin resistance. Cell Metab (2008) 2.16
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J (2004) 1.97
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. Cell Metab (2008) 1.96
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160. J Biol Chem (2006) 1.93
GLUT4 recycles via a trans-Golgi network (TGN) subdomain enriched in Syntaxins 6 and 16 but not TGN38: involvement of an acidic targeting motif. Mol Biol Cell (2003) 1.93
Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking. Traffic (2006) 1.88
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes (2002) 1.85
Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab (2008) 1.82
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2007) 1.79
Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status. J Clin Endocrinol Metab (2003) 1.74
Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway. Mol Cell Biol (2004) 1.66
Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab (2009) 1.66
Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol (2008) 1.64
Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Mol Cell Biol (2007) 1.63
An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Hum Mol Genet (2008) 1.62
Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO Rep (2004) 1.62
The role of phosphoinositide 3-kinase C2alpha in insulin signaling. J Biol Chem (2007) 1.56
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab (2013) 1.54
Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. J Biol Chem (2002) 1.51
Characterization of a distinct plasma membrane macrodomain in differentiated adipocytes. J Biol Chem (2002) 1.50
GLUT4 exocytosis. J Cell Sci (2011) 1.50
Achieving compliance with the European Working Time Directive in a large teaching hospital: a strategic approach. Clin Med (2004) 1.49
Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes (2002) 1.46
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol (2008) 1.45
Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway. J Biol Chem (2005) 1.41
GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. Mol Biol Cell (2002) 1.36
Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem (2003) 1.32
Identification of a novel glucose transporter-like protein-GLUT-12. Am J Physiol Endocrinol Metab (2002) 1.32
Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression. Mol Endocrinol (2006) 1.31
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J (2011) 1.30
Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. Diabetes (2004) 1.28
A novel hook-related protein family and the characterization of hook-related protein 1. Traffic (2005) 1.27
Mapping insulin/GLUT4 circuitry. Traffic (2011) 1.26
Fatty acid metabolism, energy expenditure and insulin resistance in muscle. J Endocrinol (2014) 1.25
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr Biol (2003) 1.22
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab (2005) 1.22
Identification of a distal GLUT4 trafficking event controlled by actin polymerization. Mol Biol Cell (2009) 1.21
Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab (2007) 1.20
The GLUT4 code. Mol Endocrinol (2007) 1.19
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. Am J Physiol Endocrinol Metab (2009) 1.19
Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition. J Gerontol A Biol Sci Med Sci (2006) 1.19
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. J Clin Invest (2004) 1.18
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17
Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice. Cancer Res (2012) 1.17
GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. J Biol Chem (2004) 1.16
Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PLoS One (2012) 1.15
Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane. Mol Endocrinol (2005) 1.15
Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association. Mol Endocrinol (2008) 1.15
Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo. Am J Physiol Endocrinol Metab (2006) 1.14
Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells. Diabetes (2010) 1.13
Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. Am J Physiol Endocrinol Metab (2006) 1.13
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2013) 1.10
Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes. Biochem J (2011) 1.10
ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling. J Clin Invest (2013) 1.08
Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proc Natl Acad Sci U S A (2012) 1.08
Insulin stimulates the entry of GLUT4 into the endosomal recycling pathway by a quantal mechanism. Traffic (2004) 1.07
Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. Am J Physiol Endocrinol Metab (2007) 1.07
Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction. Proc Natl Acad Sci U S A (2008) 1.07
The Sec1p/Munc18 (SM) protein, Vps45p, cycles on and off membranes during vesicle transport. J Cell Biol (2003) 1.06
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J (2008) 1.06
Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics. Biochemistry (2003) 1.05
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Mol Endocrinol (2009) 1.04
Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Mol Cell Proteomics (2010) 1.04
Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking. J Biol Chem (2007) 1.04
Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes. J Biol Chem (2011) 1.04
Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. Diabetes (2006) 1.02